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    Irs2 insulin receptor substrate 2 [ Mus musculus (house mouse) ]

    Gene ID: 384783, updated on 25-Jul-2016
    Official Symbol
    Irs2provided by MGI
    Official Full Name
    insulin receptor substrate 2provided by MGI
    Primary source
    MGI:MGI:109334
    See related
    Ensembl:ENSMUSG00000038894 Vega:OTTMUSG00000059106
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Irs-2
    Orthologs
    Location:
    8 A1.1; 8 5.35 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (10986961..11008430, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (10986961..11008430, complement)

    Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 3930402G23 gene Neighboring gene predicted gene, 32594 Neighboring gene RIKEN cDNA 9530052E02 gene Neighboring gene collagen, type IV, alpha 1 Neighboring gene predicted gene, 32709 Neighboring gene uncharacterized LOC108167519 Neighboring gene collagen, type IV, alpha 2

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    14-3-3 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    insulin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    insulin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatidylinositol 3-kinase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphatidylinositol 3-kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    signal transducer activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    brain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to insulin stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to insulin stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    insulin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    mammary gland development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of B cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of plasma membrane long-chain fatty acid transport ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of B cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of fatty acid beta-oxidation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of glucose import ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of glucose metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of glycogen biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of insulin secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of mesenchymal cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of lipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    response to glucose IDA
    Inferred from Direct Assay
    more info
    PubMed 
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    insulin receptor substrate 2
    Names
    4PS

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081212.1NP_001074681.1  insulin receptor substrate 2

      See identical proteins and their annotated locations for NP_001074681.1

      Status: PROVISIONAL

      Source sequence(s)
      AC113484, AC138677
      Consensus CDS
      CCDS52477.1
      UniProtKB/Swiss-Prot
      P81122
      Related
      ENSMUSP00000038514, OTTMUSP00000075523, ENSMUST00000040514, OTTMUST00000144972
      Conserved Domains (2) summary
      cd01204
      Location:191294
      PTB_IRS; Insulin receptor substrate phosphotyrosine-binding domain (PTBi)
      cd01257
      Location:31143
      PH_IRS; Insulin receptor substrate (IRS) pleckstrin homology (PH) domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

      Range
      10986961..11008430 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)