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Irf7 interferon regulatory factor 7 [ Mus musculus (house mouse) ]

Gene ID: 54123, updated on 9-May-2015
Official Symbol
Irf7provided by MGI
Official Full Name
interferon regulatory factor 7provided by MGI
Primary source
MGI:MGI:1859212
See related
Ensembl:ENSMUSG00000025498; Vega:OTTMUSG00000024538
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Orthologs
See Irf7 in MapViewer
Location:
7; 7 F5
Exon count:
10
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 7 NC_000073.6 (141263183..141266499, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (148449088..148452300, complement)

Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene microRNA 210 Neighboring gene PHD and ring finger domains 1 Neighboring gene cadherin-related family member 5 Neighboring gene secretin

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Chemically induced (ENU) (2) 
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
immune system process IEA
Inferred from Electronic Annotation
more info
 
immunoglobulin mediated immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
interferon-alpha production IMP
Inferred from Mutant Phenotype
more info
PubMed 
interferon-beta production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of interferon-alpha production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interferon-alpha production TAS
Traceable Author Statement
more info
PubMed 
positive regulation of interferon-beta production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interferon-beta production TAS
Traceable Author Statement
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
positive regulation of type I interferon production IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of type I interferon-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of MyD88-dependent toll-like receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of MyD88-independent toll-like receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of adaptive immune response ISO
Inferred from Sequence Orthology
more info
 
regulation of innate immune response TAS
Traceable Author Statement
more info
PubMed 
regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
type I interferon biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
interferon regulatory factor 7
Names
interferon regulatory factor 7
IRF-7

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252600.1NP_001239529.1  interferon regulatory factor 7 isoform 2

    See identical proteins and their annotated locations for NP_001239529.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AK152403, BQ033099, BY155234
    Consensus CDS
    CCDS57595.1
    UniProtKB/TrEMBL
    Q3TW14
    Related
    ENSMUSP00000095565, OTTMUSP00000029374, ENSMUST00000097952, OTTMUST00000060230
    Conserved Domains (2) summary
    cd00103
    Location:9124
    IRF; Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF transcription factors is important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. The ...
    pfam10401
    Location:209389
    IRF-3; Interferon-regulatory factor 3
  2. NM_001252601.1NP_001239530.1  interferon regulatory factor 7 isoform 3

    See identical proteins and their annotated locations for NP_001239530.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses a different splice site in the coding region, compared to variant 1. The resulting protein (isoform 3) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AK002830, AK151470, BQ033099, BY155234, DT923384
    Consensus CDS
    CCDS57594.1
    UniProtKB/TrEMBL
    D3Z4U9
    Conserved Domains (2) summary
    cd00103
    Location:9124
    IRF; Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF transcription factors is important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. The ...
    pfam10401
    Location:208388
    IRF-3; Interferon-regulatory factor 3
  3. NM_016850.3NP_058546.1  interferon regulatory factor 7 isoform 1

    See identical proteins and their annotated locations for NP_058546.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform 1).
    Source sequence(s)
    AK079685, BQ033099, BY155234
    Consensus CDS
    CCDS22005.1
    UniProtKB/Swiss-Prot
    P70434
    UniProtKB/TrEMBL
    Q542T3
    Related
    ENSMUSP00000026571, OTTMUSP00000029373, ENSMUST00000026571, OTTMUST00000060229
    Conserved Domains (2) summary
    cd00103
    Location:9124
    IRF; Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF transcription factors is important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. The ...
    pfam10401
    Location:240420
    IRF-3; Interferon-regulatory factor 3

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000073.6 Reference GRCm38.p3 C57BL/6J

    Range
    141263183..141266499
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006536214.1XP_006536277.1  

    Conserved Domains (2) summary
    cd00103
    Location:9124
    IRF; Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF transcription factors is important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. The ...
    pfam10401
    Location:177357
    IRF-3; Interferon-regulatory factor 3

Alternate Mm_Celera

Genomic

  1. AC_000029.1 Alternate Mm_Celera

    Range
    141056915..141060156
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)