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    Shank1 SH3/ankyrin domain gene 1 [ Mus musculus (house mouse) ]

    Gene ID: 243961, updated on 26-Jun-2016
    Official Symbol
    Shank1provided by MGI
    Official Full Name
    SH3/ankyrin domain gene 1provided by MGI
    Primary source
    MGI:MGI:3613677
    See related
    Ensembl:ENSMUSG00000038738 Vega:OTTMUSG00000016443
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Orthologs
    Location:
    7; 7 B4
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (44307899..44358353)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (51565634..51613723)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene predicted gene 7238 Neighboring gene C-type lectin domain family 11, member a Neighboring gene RIKEN cDNA 1700008O03 gene Neighboring gene predicted gene, 39001 Neighboring gene synaptotagmin III

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Glutamatergic synapse, organism-specific biosystem (from KEGG)
      Glutamatergic synapse, organism-specific biosystemGlutamate is the major excitatory neurotransmitter in the mammalian central nervous system(CNS). Glutamate is packaged into synaptic vesicles in the presynaptic terminal. Once released into the synap...
    • Glutamatergic synapse, conserved biosystem (from KEGG)
      Glutamatergic synapse, conserved biosystemGlutamate is the major excitatory neurotransmitter in the mammalian central nervous system(CNS). Glutamate is packaged into synaptic vesicles in the presynaptic terminal. Once released into the synap...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    GKAP/Homer scaffold activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    GKAP/Homer scaffold activity ISO
    Inferred from Sequence Orthology
    more info
     
    SH3 domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    ankyrin repeat binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    ionotropic glutamate receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ionotropic glutamate receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    receptor signaling complex scaffold activity ISO
    Inferred from Sequence Orthology
    more info
     
    scaffold protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    somatostatin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    adult behavior ISO
    Inferred from Sequence Orthology
    more info
     
    associative learning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    dendritic spine morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    determination of affect ISO
    Inferred from Sequence Orthology
    more info
     
    habituation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    long-term memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of actin filament bundle assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    neuromuscular process controlling balance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    olfactory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of dendritic spine development ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of excitatory postsynaptic potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    protein localization to synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    righting reflex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    social behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    social behavior ISO
    Inferred from Sequence Orthology
    more info
     
    synapse maturation ISO
    Inferred from Sequence Orthology
    more info
     
    vocalization behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    vocalization behavior ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    colocalizes_with NMDA selective glutamate receptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendritic spine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    excitatory synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with ionotropic glutamate receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    synapse ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    SH3 and multiple ankyrin repeat domains protein 1
    Names
    SH3 and multiple ankyrin repeat domains 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034115.1NP_001029287.1  SH3 and multiple ankyrin repeat domains protein 1

      See identical proteins and their annotated locations for NP_001029287.1

      Status: VALIDATED

      Source sequence(s)
      AC152939
      Consensus CDS
      CCDS52229.1
      UniProtKB/Swiss-Prot
      D3YZU1
      Related
      ENSMUSP00000103571, OTTMUSP00000017680, ENSMUST00000107938, OTTMUST00000039587
      Conserved Domains (7) summary
      cd09506
      Location:21002165
      SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
      smart00454
      Location:21032167
      SAM; Sterile alpha motif
      cd00204
      Location:274399
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd00992
      Location:661754
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam12796
      Location:318402
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:280328
      Ank_4; Ankyrin repeats (many copies)
      cl17036
      Location:557608
      SH3; Src Homology 3 domain superfamily

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      44307899..44358353
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006540864.3XP_006540927.1  

      See identical proteins and their annotated locations for XP_006540927.1

      UniProtKB/Swiss-Prot
      D3YZU1
      Conserved Domains (7) summary
      cd09506
      Location:21002165
      SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
      smart00454
      Location:21032167
      SAM; Sterile alpha motif
      cd00204
      Location:274399
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd00992
      Location:661754
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam12796
      Location:318402
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:280328
      Ank_4; Ankyrin repeats (many copies)
      cl17036
      Location:557608
      SH3; Src Homology 3 domain superfamily
    2. XM_006540868.3XP_006540931.1  

      Conserved Domains (5) summary
      cd00204
      Location:274399
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd00992
      Location:661754
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam12796
      Location:318402
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:280328
      Ank_4; Ankyrin repeats (many copies)
      cl17036
      Location:557608
      SH3; Src Homology 3 domain superfamily
    3. XM_006540867.3XP_006540930.1  

      Conserved Domains (5) summary
      cd00204
      Location:274399
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd00992
      Location:661754
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam12796
      Location:318402
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:280328
      Ank_4; Ankyrin repeats (many copies)
      cl17036
      Location:557608
      SH3; Src Homology 3 domain superfamily
    4. XM_006540865.3XP_006540928.1  

      UniProtKB/TrEMBL
      D3YZU4
      Related
      ENSMUSP00000103568, OTTMUSP00000017682, ENSMUST00000107935, OTTMUST00000039589
      Conserved Domains (7) summary
      cd09506
      Location:20922157
      SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
      smart00454
      Location:20952159
      SAM; Sterile alpha motif
      cd00204
      Location:274399
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd00992
      Location:661754
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam12796
      Location:318402
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:280328
      Ank_4; Ankyrin repeats (many copies)
      cl17036
      Location:557608
      SH3; Src Homology 3 domain superfamily
    5. XM_006540866.3XP_006540929.1  

      UniProtKB/TrEMBL
      D3YZU5
      Related
      ENSMUSP00000103567, OTTMUSP00000017681, ENSMUST00000107934, OTTMUST00000039588
      Conserved Domains (7) summary
      cd09506
      Location:20912156
      SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
      smart00454
      Location:20942158
      SAM; Sterile alpha motif
      cd00204
      Location:274399
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd00992
      Location:652745
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam12796
      Location:318402
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:280328
      Ank_4; Ankyrin repeats (many copies)
      cl17036
      Location:557608
      SH3; Src Homology 3 domain superfamily
    6. XM_006540874.1XP_006540937.1  

      Conserved Domains (3) summary
      cd09506
      Location:14501515
      SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
      smart00454
      Location:14531517
      SAM; Sterile alpha motif
      cd00992
      Location:51104
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    7. XM_006540872.1XP_006540935.1  

      Conserved Domains (3) summary
      cd09506
      Location:14861551
      SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
      smart00454
      Location:14891553
      SAM; Sterile alpha motif
      cd00992
      Location:47140
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    8. XM_006540869.2XP_006540932.1  

      Conserved Domains (3) summary
      cd09506
      Location:15781643
      SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
      smart00454
      Location:15811645
      SAM; Sterile alpha motif
      cd00992
      Location:179232
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    9. XM_006540870.2XP_006540933.1  

      Conserved Domains (3) summary
      cd09506
      Location:15621627
      SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
      smart00454
      Location:15651629
      SAM; Sterile alpha motif
      cd00992
      Location:150216
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    10. XM_006540871.2XP_006540934.2  

      Conserved Domains (3) summary
      cd09506
      Location:14481513
      SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
      smart00454
      Location:14511515
      SAM; Sterile alpha motif
      cd00992
      Location:9102
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    11. XM_006540876.3XP_006540939.1  

      Conserved Domains (2) summary
      cd09506
      Location:12081273
      SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
      smart00454
      Location:12111275
      SAM; Sterile alpha motif
    12. XM_006540875.3XP_006540938.1  

      Conserved Domains (2) summary
      cd09506
      Location:12431308
      SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
      smart00454
      Location:12461310
      SAM; Sterile alpha motif