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MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase [ Homo sapiens (human) ]

Gene ID: 4193, updated on 8-Jul-2014
Official Symbol
MDM2provided by HGNC
Official Full Name
MDM2 proto-oncogene, E3 ubiquitin protein ligaseprovided by HGNC
Primary source
HGNC:6973
See related
Ensembl:ENSG00000135679; HPRD:01272; MIM:164785; Vega:OTTHUMG00000142827
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HDMX; hdm2; ACTFS
Summary
This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013]
See MDM2 in Epigenomics, MapViewer
Location:
12q14.3-q15
Exon count :
13
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 12 NC_000012.12 (68808172..68845544)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (69201952..69239324)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase-activated protein kinase 2 pseudogene Neighboring gene SUZ RNA binding domain containing 1 pseudogene Neighboring gene carboxypeptidase M Neighboring gene PRELI domain containing 2 pseudogene Neighboring gene cleavage and polyadenylation specific factor 6, 68kDa Neighboring gene microRNA 1279

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Tat, p14 tat Ubiquitination of HIV-1 Tat by Hdm2 is required for efficient replication of HIV-1, indicating Hdm2 regulates Tat function and is a Tat co-activator PubMed
tat Hdm2 interacts directly with HIV-1 Tat and ubiquitinates Tat on amino acid residue Lys71 PubMed
Vif, p23 vif MDM2 reduces cellular Vif levels and reversely increases A3G levels, because the interaction between MDM2 and Vif prevents A3G from binding to Vif PubMed
vif MDM2 inhibits HIV-1 replication in non-permissive target cells through Vif degradation PubMed
vif The N-terminal region (residues 1-50) of HIV-1 Vif is important for binding to MDM2. The interaction domain of MDM2 with Vif to amino-acids 168-320, which are located in its central acidic and zinc-finger domains PubMed
vif HIV-1 Vif stabilizes TP53 by blocking MDM2-induced ubiquitination and inhibits MDM2-mediated nuclear export of TP53, leading to support viral replication through inducing G2 cell cycle arrest PubMed

Go to the HIV-1, Human Protein Interaction Database

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  • Direct p53 effectors, organism-specific biosystem (from Pathway Interaction Database)
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    Direct p53 effectors
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  • Downstream signal transduction, organism-specific biosystem (from REACTOME)
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  • Endocytosis, organism-specific biosystem (from KEGG)
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  • Glioma, organism-specific biosystem (from KEGG)
    Glioma, organism-specific biosystemGliomas are the most common of the primary brain tumors and account for more than 40% of all central nervous system neoplasms. Gliomas include tumours that are composed predominantly of astrocytes (a...
  • Glioma, conserved biosystem (from KEGG)
    Glioma, conserved biosystemGliomas are the most common of the primary brain tumors and account for more than 40% of all central nervous system neoplasms. Gliomas include tumours that are composed predominantly of astrocytes (a...
  • Glucocorticoid receptor regulatory network, organism-specific biosystem (from Pathway Interaction Database)
    Glucocorticoid receptor regulatory network, organism-specific biosystem
    Glucocorticoid receptor regulatory network
  • Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity, organism-specific biosystem (from REACTOME)
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  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
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  • Integrated Breast Cancer Pathway, organism-specific biosystem (from WikiPathways)
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  • Integrated Cancer pathway, organism-specific biosystem (from WikiPathways)
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  • Integrated Pancreatic Cancer Pathway, organism-specific biosystem (from WikiPathways)
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  • Melanoma, organism-specific biosystem (from KEGG)
    Melanoma, organism-specific biosystemMelanoma is a form of skin cancer that has a poor prognosis and which is on the rise in Western populations. Melanoma arises from the malignant transformation of pigment-producing cells, melanocytes...
  • Melanoma, conserved biosystem (from KEGG)
    Melanoma, conserved biosystemMelanoma is a form of skin cancer that has a poor prognosis and which is on the rise in Western populations. Melanoma arises from the malignant transformation of pigment-producing cells, melanocytes...
  • MicroRNAs in cancer, organism-specific biosystem (from KEGG)
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  • Neuronal System, organism-specific biosystem (from REACTOME)
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  • Oncogene Induced Senescence, organism-specific biosystem (from REACTOME)
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  • Oxidative Stress Induced Senescence, organism-specific biosystem (from REACTOME)
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  • PI3K/AKT Signaling in Cancer, organism-specific biosystem (from REACTOME)
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  • Pathways in cancer, organism-specific biosystem (from KEGG)
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  • Signaling by ERBB4, organism-specific biosystem (from REACTOME)
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  • Signaling by FGFR, organism-specific biosystem (from REACTOME)
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  • Signaling by FGFR in disease, organism-specific biosystem (from REACTOME)
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  • Signaling by the B Cell Receptor (BCR), organism-specific biosystem (from REACTOME)
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  • Signalling by NGF, organism-specific biosystem (from REACTOME)
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  • Stabilization of p53, organism-specific biosystem (from REACTOME)
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  • Sumoylation by RanBP2 regulates transcriptional repression, organism-specific biosystem (from Pathway Interaction Database)
    Sumoylation by RanBP2 regulates transcriptional repression, organism-specific biosystem
    Sumoylation by RanBP2 regulates transcriptional repression
  • TP53 network, organism-specific biosystem (from WikiPathways)
    TP53 network, organism-specific biosystemP53 is not a lonely genome guardian, it operates with the assistance of p73 and p63 within a complex network including distinct but complementary pathways. This protein family presents a high le...
  • Thyroid hormone signaling pathway, organism-specific biosystem (from KEGG)
    Thyroid hormone signaling pathway, organism-specific biosystemThe thyroid hormones (THs) are important regulators of growth, development and metabolism. The action of TH is mainly mediated by T3 (3,5,3'-triiodo-L-thyronine). Thyroid hormones, L-thyroxine (T4) a...
  • Trafficking of AMPA receptors, organism-specific biosystem (from REACTOME)
    Trafficking of AMPA receptors, organism-specific biosystemRepetitive presynaptic activity causes long lasting changes in the postsynaptic transmission by changing the type and the number of AMPA receptors. These changes are brought about by trafficking mec...
  • Transcriptional misregulation in cancer, organism-specific biosystem (from KEGG)
    Transcriptional misregulation in cancer, organism-specific biosystem
    Transcriptional misregulation in cancer
  • Transcriptional misregulation in cancer, conserved biosystem (from KEGG)
    Transcriptional misregulation in cancer, conserved biosystem
    Transcriptional misregulation in cancer
  • Transmission across Chemical Synapses, organism-specific biosystem (from REACTOME)
    Transmission across Chemical Synapses, organism-specific biosystemChemical synapses are specialized junctions that are used for communication between neurons, neurons and muscle or gland cells. The synapse involves a pre-synaptic neuron and a post-synaptic neuron,...
  • Tryptophan metabolism, organism-specific biosystem (from WikiPathways)
    Tryptophan metabolism, organism-specific biosystem
    Tryptophan metabolism
  • Ubiquitin mediated proteolysis, organism-specific biosystem (from KEGG)
    Ubiquitin mediated proteolysis, organism-specific biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
  • Ubiquitin mediated proteolysis, conserved biosystem (from KEGG)
    Ubiquitin mediated proteolysis, conserved biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
  • Viral carcinogenesis, organism-specific biosystem (from KEGG)
    Viral carcinogenesis, organism-specific biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
  • Viral carcinogenesis, conserved biosystem (from KEGG)
    Viral carcinogenesis, conserved biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
  • p53 pathway, organism-specific biosystem (from Pathway Interaction Database)
    p53 pathway, organism-specific biosystem
    p53 pathway
  • p53 signaling pathway, organism-specific biosystem (from KEGG)
    p53 signaling pathway, organism-specific biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
  • p53 signaling pathway, conserved biosystem (from KEGG)
    p53 signaling pathway, conserved biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
  • p53-Dependent G1 DNA Damage Response, organism-specific biosystem (from REACTOME)
    p53-Dependent G1 DNA Damage Response, organism-specific biosystemMost of the damage-induced modifications of p53 are dependent on the ATM kinase. The first link between ATM and p53 was predicted based on the earlier studies that showed that AT cells exhibit a redu...
  • p53-Dependent G1/S DNA damage checkpoint, organism-specific biosystem (from REACTOME)
    p53-Dependent G1/S DNA damage checkpoint, organism-specific biosystemThe arrest at G1/S checkpoint is mediated by the action of a widely known tumor suppressor protein, p53. Loss of p53 functions, as a result of mutations in cancer prevent the G1/S checkpoint (Kuerbi...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ligase activity IEA
Inferred from Electronic Annotation
more info
 
p53 binding IPI
Inferred from Physical Interaction
more info
PubMed 
peroxisome proliferator activated receptor binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
scaffold protein binding IEA
Inferred from Electronic Annotation
more info
 
ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin-protein transferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest IMP
Inferred from Mutant Phenotype
more info
 
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS
Traceable Author Statement
more info
 
Fc-epsilon receptor signaling pathway TAS
Traceable Author Statement
more info
 
cellular response to UV-C IEA
Inferred from Electronic Annotation
more info
 
cellular response to acid IEA
Inferred from Electronic Annotation
more info
 
cellular response to alkaloid IEA
Inferred from Electronic Annotation
more info
 
cellular response to antibiotic IEA
Inferred from Electronic Annotation
more info
 
cellular response to estrogen stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to hydrogen peroxide IEA
Inferred from Electronic Annotation
more info
 
cellular response to hypoxia IEP
Inferred from Expression Pattern
more info
 
cellular response to peptide hormone stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to vitamin B1 IEA
Inferred from Electronic Annotation
more info
 
epidermal growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
establishment of protein localization IDA
Inferred from Direct Assay
more info
PubMed 
fibroblast growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
innate immune response TAS
Traceable Author Statement
more info
 
negative regulation of DNA damage response, signal transduction by p53 class mediator IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell cycle arrest IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein processing IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
neurotrophin TRK receptor signaling pathway TAS
Traceable Author Statement
more info
 
peptidyl-lysine modification IMP
Inferred from Mutant Phenotype
more info
PubMed 
phosphatidylinositol-mediated signaling TAS
Traceable Author Statement
more info
 
positive regulation of cell proliferation TAS
Traceable Author Statement
more info
PubMed 
positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
positive regulation of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein export from nucleus IEA
Inferred from Electronic Annotation
more info
 
protein complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
protein destabilization IDA
Inferred from Direct Assay
more info
PubMed 
protein localization to nucleus IDA
Inferred from Direct Assay
more info
PubMed 
protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein ubiquitination involved in ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
regulation of protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
response to antibiotic IEP
Inferred from Expression Pattern
more info
 
response to carbohydrate IEA
Inferred from Electronic Annotation
more info
 
response to cocaine IEA
Inferred from Electronic Annotation
more info
 
response to drug IEA
Inferred from Electronic Annotation
more info
 
response to ether IEA
Inferred from Electronic Annotation
more info
 
response to iron ion IEA
Inferred from Electronic Annotation
more info
 
response to magnesium ion IEA
Inferred from Electronic Annotation
more info
 
response to morphine IEA
Inferred from Electronic Annotation
more info
 
synaptic transmission TAS
Traceable Author Statement
more info
 
traversing start control point of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IMP
Inferred from Mutant Phenotype
more info
 
cytosol TAS
Traceable Author Statement
more info
 
endocytic vesicle membrane TAS
Traceable Author Statement
more info
 
colocalizes_with nuclear body IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IMP
Inferred from Mutant Phenotype
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
protein complex IDA
Inferred from Direct Assay
more info
PubMed 
synapse IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
E3 ubiquitin-protein ligase Mdm2
Names
E3 ubiquitin-protein ligase Mdm2
oncoprotein Mdm2
MDM2 oncogene, E3 ubiquitin protein ligase
Mdm2, p53 E3 ubiquitin protein ligase homolog
double minute 2, human homolog of; p53-binding protein
Mdm2, transformed 3T3 cell double minute 2, p53 binding protein
NP_001138809.1
NP_001138811.1
NP_001138812.1
NP_001265391.1
NP_002383.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016708.1 

    Range
    4982..42354
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001145337.2NP_001138809.1  E3 ubiquitin-protein ligase Mdm2 isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3, also known as P2-MDM2-10) contains multiple differences in the 5' UTR and coding region, compared to variant 1. It uses an alternate promoter and initiates translation at a downstream in-frame start codon. The encoded isoform (g) has a shorter N-terminus and is shorter than isoform a.
    Source sequence(s)
    AC025423, BE930512, EU076747, EU076748
    UniProtKB/TrEMBL
    A7UKX8
    UniProtKB/TrEMBL
    A7UKX9
    Conserved Domains (3) summary
    cd00162
    Location:391435
    Blast Score: 79
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...
    pfam00641
    Location:252280
    Blast Score: 107
    zf-RanBP; Zn-finger in Ran binding protein and others
    pfam02201
    Location:40100
    Blast Score: 180
    SWIB; SWIB/MDM2 domain
  2. NM_001145339.2NP_001138811.1  E3 ubiquitin-protein ligase Mdm2 isoform h

    See proteins identical to NP_001138811.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also known as MDM2g) lacks two coding exons, but maintains the reading frame, compared to variant 1. The encoded isoform (h) is shorter than isoform a.
    Source sequence(s)
    AC025423, AF092844, BE930512, HY174841
    UniProtKB/TrEMBL
    G3XA89
    UniProtKB/Swiss-Prot
    Q00987
    Related
    ENSP00000258149, ENST00000258149
    Conserved Domains (3) summary
    cd00162
    Location:389433
    Blast Score: 81
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...
    pfam00641
    Location:250278
    Blast Score: 109
    zf-RanBP; Zn-finger in Ran binding protein and others
    pfam02201
    Location:46106
    Blast Score: 180
    SWIB; SWIB/MDM2 domain
  3. NM_001145340.2NP_001138812.1  E3 ubiquitin-protein ligase Mdm2 isoform i

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4, also known as P2-MDM2-C1) contains multiple differences in the 5' UTR and coding region, compared to variant 1. It uses an alternate promoter and initiates translation at a downstream in-frame start codon. The encoded isoform (i) has a shorter N-terminus and is shorter than isoform a.
    Source sequence(s)
    AC025423, AF385327, BE930512, EU076746
    UniProtKB/TrEMBL
    A7UKX7
    UniProtKB/TrEMBL
    Q96DS0
    Conserved Domains (2) summary
    cd00162
    Location:242286
    Blast Score: 78
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...
    pfam00641
    Location:104131
    Blast Score: 104
    zf-RanBP; Zn-finger in Ran binding protein and others
  4. NM_001278462.1NP_001265391.1  E3 ubiquitin-protein ligase Mdm2 isoform l

    See proteins identical to NP_001265391.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5, also known as P2-MDM2-C) contains multiple differences in the 5' UTR and coding region, compared to variant 1. It uses an alternate promoter and initiates translation at a downstream in-frame start codon. The encoded isoform (l) has a shorter N-terminus and is shorter than isoform a.
    Source sequence(s)
    AC025423, AF385327, AK290341, BE930512, EU076748
    Consensus CDS
    CCDS61189.1
    UniProtKB/TrEMBL
    A7UKX9
    UniProtKB/Swiss-Prot
    Q00987
    UniProtKB/TrEMBL
    Q96DS0
    Related
    ENSP00000348637, ENST00000356290
    Conserved Domains (2) summary
    cd00162
    Location:268312
    Blast Score: 80
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...
    pfam00641
    Location:129157
    Blast Score: 106
    zf-RanBP; Zn-finger in Ran binding protein and others
  5. NM_002392.5NP_002383.2  E3 ubiquitin-protein ligase Mdm2 isoform a

    See proteins identical to NP_002383.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC025423, AK290341, BE930512, HY174841
    Consensus CDS
    CCDS8986.2
    UniProtKB/Swiss-Prot
    Q00987
    Related
    ENSP00000417281, OTTHUMP00000183488, ENST00000462284, OTTHUMT00000286419
    Conserved Domains (3) summary
    cd00162
    Location:444488
    Blast Score: 82
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...
    pfam00641
    Location:305333
    Blast Score: 109
    zf-RanBP; Zn-finger in Ran binding protein and others
    pfam02201
    Location:46106
    Blast Score: 181
    SWIB; SWIB/MDM2 domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000012.12 

    Range
    68808172..68845544
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006719400.1XP_006719463.1  

    See proteins identical to XP_006719463.1

    Conserved Domains (2) summary
    cd00162
    Location:337381
    Blast Score: 79
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...
    pfam00641
    Location:198226
    Blast Score: 106
    zf-RanBP; Zn-finger in Ran binding protein and others
  2. XM_005268872.2XP_005268929.1  

    See proteins identical to XP_005268929.1

    UniProtKB/Swiss-Prot
    Q00987
    Conserved Domains (3) summary
    cd00162
    Location:438482
    Blast Score: 82
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...
    pfam00641
    Location:299327
    Blast Score: 109
    zf-RanBP; Zn-finger in Ran binding protein and others
    pfam02201
    Location:40100
    Blast Score: 181
    SWIB; SWIB/MDM2 domain
  3. XM_006719399.1XP_006719462.1  

    UniProtKB/Swiss-Prot
    Q00987
    Conserved Domains (3) summary
    cd00162
    Location:377421
    Blast Score: 80
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...
    pfam00641
    Location:238266
    Blast Score: 107
    zf-RanBP; Zn-finger in Ran binding protein and others
    cl02489
    Location:139
    Blast Score: 111
    SWIB; SWIB/MDM2 domain

Alternate HuRef

Genomic

  1. AC_000144.1 

    Range
    66252410..66289884
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018923.2 

    Range
    69170604..69207918
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001145336.1: Suppressed sequence

    Description
    NM_001145336.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  2. NM_006878.3: Suppressed sequence

    Description
    NM_006878.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript, which lacks consecutive internal exons and contains non-consensus splice sites, compared to the reported wild-type transcript.
  3. NM_006879.3: Suppressed sequence

    Description
    NM_006879.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript, which lacks consecutive internal exons and contains non-consensus splice sites, compared to the reported wild-type transcript.
  4. NM_006880.2: Suppressed sequence

    Description
    NM_006880.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
  5. NM_006881.3: Suppressed sequence

    Description
    NM_006881.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript, which lacks consecutive internal exons and contains non-consensus splice sites, compared to the reported wild-type transcript.
  6. NM_006882.3: Suppressed sequence

    Description
    NM_006882.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript, which lacks consecutive internal exons and contains non-consensus splice sites, compared to the reported wild-type transcript.
  7. NM_032739.1: Suppressed sequence

    Description
    NM_032739.1: This RefSeq was permanently suppressed because it is primarily UTR sequence.

Supplemental Content

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