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Hfe hemochromatosis [ Mus musculus (house mouse) ]

Gene ID: 15216, updated on 17-Sep-2014
Official Symbol
Hfeprovided by MGI
Official Full Name
hemochromatosisprovided by MGI
Primary source
MGI:109191
Locus tag
RP23-480B19.9
See related
Ensembl:ENSMUSG00000006611; Vega:OTTMUSG00000000737
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MR2
Location:
13 A2-A4; 13 9.88 cM
Exon count:
7
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 13 NC_000079.6 (23702483..23710985, complement)

Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene histone cluster 1, H1t Neighboring gene histone cluster 1, H4c Neighboring gene family with sequence similarity 113, member A pseudogene Neighboring gene histone cluster 1, H1c

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Iron Homeostasis, organism-specific biosystem (from WikiPathways)
    Iron Homeostasis, organism-specific biosystemIron is nessisary for all mammalian cells but is also toxic in excess. This pathway shows the regulation of iron between a cell and the blood stream.

Markers

Homology

Clone Names

  • MGC151121, MGC151123

Gene Ontology Provided by MGI

Function Evidence Code Pubs
antigen binding IBA
Inferred from Biological aspect of Ancestor
more info
 
peptide antigen binding IEA
Inferred from Electronic Annotation
more info
 
receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
antigen processing and presentation IBA
Inferred from Biological aspect of Ancestor
more info
 
antigen processing and presentation of peptide antigen via MHC class I IEA
Inferred from Electronic Annotation
more info
 
hormone biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
immune response IEA
Inferred from Electronic Annotation
more info
 
immune system process IEA
Inferred from Electronic Annotation
more info
 
iron ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
iron ion import into cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
iron ion import into cell ISO
Inferred from Sequence Orthology
more info
 
multicellular organismal iron ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of T cell mediated cytotoxicity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
MHC class I protein complex IEA
Inferred from Electronic Annotation
more info
 
apical part of cell ISO
Inferred from Sequence Orthology
more info
 
basal part of cell ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
early endosome ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
recycling endosome ISO
Inferred from Sequence Orthology
more info
 
terminal web ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
hereditary hemochromatosis protein homolog
Names
hereditary hemochromatosis protein homolog

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010424.4NP_034554.2  hereditary hemochromatosis protein homolog precursor

    See proteins identical to NP_034554.2

    Status: PROVISIONAL

    Source sequence(s)
    AL590388, AL592149
    Consensus CDS
    CCDS26360.1
    UniProtKB/Swiss-Prot
    P70387
    Related
    ENSMUSP00000089298, OTTMUSP00000000659, ENSMUST00000091706, OTTMUST00000001384
    Conserved Domains (2) summary
    cl08246
    Location:31214
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
    cl11960
    Location:218310
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000079.6 

    Range
    23702483..23710985
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516557.1XP_006516620.1  

    See proteins identical to XP_006516620.1

    UniProtKB/TrEMBL
    Q5SZ87
    Conserved Domains (2) summary
    cl08246
    Location:39126
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
    cl11960
    Location:130222
    Ig; Immunoglobulin domain
  2. XM_006516556.1XP_006516619.1  

    Conserved Domains (2) summary
    cl08246
    Location:4176
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
    cl11960
    Location:180272
    Ig; Immunoglobulin domain

Alternate Mm_Celera

Genomic

  1. AC_000035.1 

    Range
    23935174..23942163
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)