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LTF lactotransferrin [ Bos taurus (cattle) ]

Gene ID: 280846, updated on 23-May-2015
Gene symbol
LTF
Gene description
lactotransferrin
See related
BGD:BT26175; Ensembl:ENSBTAG00000001292
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
Lf
Orthologs
See LTF in MapViewer
Location:
22q24
Exon count:
19
Annotation release Status Assembly Chr Location
104 current Bos_taurus_UMD_3.1.1 (GCF_000003055.6) 22 AC_000179.1 (53514781..53556090)

Chromosome 22 - AC_000179.1Genomic Context describing neighboring genes Neighboring gene teratocarcinoma-derived growth factor 1 Neighboring gene leucine rich repeat containing 2 Neighboring gene uncharacterized LOC101907442 Neighboring gene receptor (chemosensory) transporter protein 3 Neighboring gene C-C chemokine receptor type 1-like Neighboring gene chemokine (C-C motif) receptor-like 2 Neighboring gene chemokine (C-C motif) receptor 5

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
heparin binding IEA
Inferred from Electronic Annotation
more info
 
iron ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activator activity IEA
Inferred from Electronic Annotation
more info
 
receptor binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
antibacterial humoral response IDA
Inferred from Direct Assay
more info
PubMed 
antifungal humoral response ISS
Inferred from Sequence or Structural Similarity
more info
 
bone morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
innate immune response in mucosa ISS
Inferred from Sequence or Structural Similarity
more info
 
ion transport IEA
Inferred from Electronic Annotation
more info
 
iron ion homeostasis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of lipopolysaccharide-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of osteoclast development IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of single-species biofilm formation in or on host organism ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of tumor necrosis factor (ligand) superfamily member 11 production IDA
Inferred from Direct Assay
more info
PubMed 
ossification IEA
Inferred from Electronic Annotation
more info
 
positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
Inferred from Electronic Annotation
more info
 
positive regulation of NF-kappaB transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of bone mineralization involved in bone maturation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of chondrocyte proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of osteoblast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of osteoblast proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of toll-like receptor 4 signaling pathway IEA
Inferred from Electronic Annotation
more info
 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
regulation of cytokine production ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of tumor necrosis factor production ISS
Inferred from Sequence or Structural Similarity
more info
 
retina homeostasis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular exosome IEA
Inferred from Electronic Annotation
more info
 
extracellular space IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
specific granule ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
lactotransferrin
Names
lactotransferrin
lactoferrin
NP_851341.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_180998.2NP_851341.1  lactotransferrin precursor

    See identical proteins and their annotated locations for NP_851341.1

    Status: PROVISIONAL

    Source sequence(s)
    L08604
    UniProtKB/TrEMBL
    B9VPZ5
    UniProtKB/Swiss-Prot
    P24627
    Related
    ENSBTAP00000001704, ENSBTAT00000001704
    Conserved Domains (4) summary
    smart00094
    Location:364693
    TR_FER; Transferrin
    pfam00405
    Location:25352
    Transferrin; Transferrin
    cd13617
    Location:361692
    PBP2_transferrin_C; The C-lobe of transferrin, a member of the type 2 periplasmic binding protein fold superfamily
    cd13618
    Location:24351
    PBP2_transferrin_N; The N-lobe of transferrin, a member of the type 2 periplasmic binding protein fold superfamily

RefSeqs of Annotated Genomes: Bos taurus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Bos_taurus_UMD_3.1.1 Primary Assembly

Genomic

  1. AC_000179.1 Reference Bos_taurus_UMD_3.1.1 Primary Assembly

    Range
    53514781..53556090
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005223020.2XP_005223077.1  

    See identical proteins and their annotated locations for XP_005223077.1

    UniProtKB/TrEMBL
    B9VPZ5
    UniProtKB/Swiss-Prot
    P24627
    Conserved Domains (4) summary
    smart00094
    Location:364693
    TR_FER; Transferrin
    pfam00405
    Location:25352
    Transferrin; Transferrin
    cd13617
    Location:361692
    PBP2_transferrin_C; The C-lobe of transferrin, a member of the type 2 periplasmic binding protein fold superfamily
    cd13618
    Location:24351
    PBP2_transferrin_N; The N-lobe of transferrin, a member of the type 2 periplasmic binding protein fold superfamily

Alternate Btau_4.6.1

Genomic

  1. NC_007320.5 Alternate Btau_4.6.1

    Range
    54057027..54090432
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)