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Tln1 talin 1 [ Mus musculus (house mouse) ]

Gene ID: 21894, updated on 8-Dec-2014
Official Symbol
Tln1provided by MGI
Official Full Name
talin 1provided by MGI
Primary source
MGI:MGI:1099832
Locus tag
RP23-195K8.11-001
See related
Ensembl:ENSMUSG00000028465; Vega:OTTMUSG00000006961
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tln
See Tln1 in Epigenomics, MapViewer
Location:
4 B1; 4
Exon count:
60
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 4 NC_000070.6 (43531513..43562583, complement)

Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 30166 Neighboring gene carbonic anhydrase 9 Neighboring gene tropomyosin 2, beta Neighboring gene cAMP responsive element binding protein 3 Neighboring gene glucosidase beta 2 Neighboring gene RGP1 retrograde golgi transport homolog (S. cerevisiae) Neighboring gene microseminoprotein, prostate associated

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
LIM domain binding ISO
Inferred from Sequence Orthology
more info
 
actin binding IEA
Inferred from Electronic Annotation
more info
 
actin filament binding IEA
Inferred from Electronic Annotation
more info
 
insulin receptor binding IEA
Inferred from Electronic Annotation
more info
 
integrin binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein complex binding ISO
Inferred from Sequence Orthology
more info
 
structural constituent of cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
vinculin binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
cell-substrate junction assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
cortical actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytoskeletal anchoring at plasma membrane IEA
Inferred from Electronic Annotation
more info
 
platelet aggregation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cell junction IEA
Inferred from Electronic Annotation
more info
 
cell projection IEA
Inferred from Electronic Annotation
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
extracellular vesicular exosome ISO
Inferred from Sequence Orthology
more info
 
focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
focal adhesion ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
microtubule organizing center ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
ruffle IEA
Inferred from Electronic Annotation
more info
 

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011602.5NP_035732.2  talin-1

    See proteins identical to NP_035732.2

    Status: VALIDATED

    Source sequence(s)
    AK122420, AK147228, AL732506, BC121787, CJ242702
    Consensus CDS
    CCDS18101.1
    UniProtKB/Swiss-Prot
    P26039
    UniProtKB/TrEMBL
    Q0V930
    UniProtKB/TrEMBL
    Q3UHS6
    UniProtKB/TrEMBL
    Q80TM2
    Related
    ENSMUSP00000030187, OTTMUSP00000007396, ENSMUST00000030187, OTTMUST00000016126
    Conserved Domains (9) summary
    pfam09141
    Location:491652
    Talin_middle; Talin, middle domain
    cd12150
    Location:16541826
    talin-RS; rod-segment of the talin C-terminal domain
    smart00295
    Location:88313
    B41; Band 4.1 homologues
    smart00307
    Location:23362532
    ILWEQ; I/LWEQ domain
    cd10569
    Location:309400
    FERM_C_Talin; Talin FERM domain C-lobe/F3
    pfam00373
    Location:207313
    FERM_M; FERM central domain
    pfam08913
    Location:18491973
    VBS; Vinculin Binding Site
    pfam09379
    Location:90199
    FERM_N; FERM N-terminal domain
    cl19756
    Location:607759
    I_LWEQ; I/LWEQ domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000070.6 

    Range
    43531513..43562583
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006537769.1XP_006537832.1  

    Conserved Domains (9) summary
    pfam09141
    Location:560721
    Talin_middle; Talin, middle domain
    cd12150
    Location:17231895
    talin-RS; rod-segment of the talin C-terminal domain
    smart00295
    Location:157382
    B41; Band 4.1 homologues
    smart00307
    Location:24052601
    ILWEQ; I/LWEQ domain
    cd10569
    Location:378469
    FERM_C_Talin; Talin FERM domain C-lobe/F3
    pfam00373
    Location:276382
    FERM_M; FERM central domain
    pfam08913
    Location:19182042
    VBS; Vinculin Binding Site
    pfam09379
    Location:159268
    FERM_N; FERM N-terminal domain
    cl19756
    Location:676828
    I_LWEQ; I/LWEQ domain
  2. XM_006537768.1XP_006537831.1  

    Conserved Domains (8) summary
    pfam09141
    Location:560721
    Talin_middle; Talin, middle domain
    cd12150
    Location:17401912
    talin-RS; rod-segment of the talin C-terminal domain
    smart00295
    Location:157382
    B41; Band 4.1 homologues
    smart00307
    Location:24222618
    ILWEQ; I/LWEQ domain
    cd10569
    Location:378469
    FERM_C_Talin; Talin FERM domain C-lobe/F3
    pfam00373
    Location:276382
    FERM_M; FERM central domain
    pfam08913
    Location:19352059
    VBS; Vinculin Binding Site
    pfam09379
    Location:159268
    FERM_N; FERM N-terminal domain
  3. XM_006537770.1XP_006537833.1  

    Conserved Domains (8) summary
    pfam09141
    Location:491652
    Talin_middle; Talin, middle domain
    cd12150
    Location:16711843
    talin-RS; rod-segment of the talin C-terminal domain
    smart00295
    Location:88313
    B41; Band 4.1 homologues
    smart00307
    Location:23532549
    ILWEQ; I/LWEQ domain
    cd10569
    Location:309400
    FERM_C_Talin; Talin FERM domain C-lobe/F3
    pfam00373
    Location:207313
    FERM_M; FERM central domain
    pfam08913
    Location:18661990
    VBS; Vinculin Binding Site
    pfam09379
    Location:90199
    FERM_N; FERM N-terminal domain
  4. XM_006537771.1XP_006537834.1  

    Conserved Domains (7) summary
    pfam09141
    Location:560721
    Talin_middle; Talin, middle domain
    cd12150
    Location:17401912
    talin-RS; rod-segment of the talin C-terminal domain
    smart00295
    Location:157382
    B41; Band 4.1 homologues
    cd10569
    Location:378469
    FERM_C_Talin; Talin FERM domain C-lobe/F3
    pfam00373
    Location:276382
    FERM_M; FERM central domain
    pfam08913
    Location:19352059
    VBS; Vinculin Binding Site
    pfam09379
    Location:159268
    FERM_N; FERM N-terminal domain

Alternate Mm_Celera

Genomic

  1. AC_000026.1 

    Range
    43565322..43596576
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)