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NEUROG3 neurogenin 3 [ Homo sapiens (human) ]

Gene ID: 50674, updated on 7-Dec-2014
Official Symbol
NEUROG3provided by HGNC
Official Full Name
neurogenin 3provided by HGNC
Primary source
HGNC:HGNC:13806
See related
HPRD:05346; MIM:604882
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ngn3; Atoh5; NGN-3; Math4B; bHLHa7
Summary
The protein encoded by this gene is a basic helix-loop-helix (bHLH) transcription factor involved in neurogenesis. The encoded protein likely acts as a heterodimer with another bHLH protein. Defects in this gene are a cause of congenital malabsorptive diarrhea 4 (DIAR4).[provided by RefSeq, May 2010]
See NEUROG3 in Epigenomics, MapViewer
Location:
10q21.3
Exon count:
2
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 10 NC_000010.11 (69572035..69573454, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (71331791..71333210, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene tetraspanin 15 Neighboring gene ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9) pseudogene 7 Neighboring gene transmembrane protein 256 pseudogene 1 Neighboring gene uncharacterized LOC101929021 Neighboring gene MT-ND2 pseudogene 15 Neighboring gene MT-ND1 pseudogene 20

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Replication interactions

Interaction Pubs
Knockdown of neurogenin 3 (NEUROG3) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
central nervous system development TAS
Traceable Author Statement
more info
PubMed 
endocrine pancreas development TAS
Traceable Author Statement
more info
 
epithelial cell differentiation IEA
Inferred from Electronic Annotation
more info
 
forebrain development IEA
Inferred from Electronic Annotation
more info
 
hindbrain development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
nervous system development TAS
Traceable Author Statement
more info
PubMed 
peripheral nervous system development TAS
Traceable Author Statement
more info
PubMed 
positive regulation of neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of sequence-specific DNA binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
regulation of dendrite morphogenesis IEA
Inferred from Electronic Annotation
more info
 
spinal cord development IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
transdifferentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
neurogenin-3
Names
neurogenin-3
protein atonal homolog 5
class A basic helix-loop-helix protein 7

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021321.1 

    Range
    5001..6420
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_020999.3NP_066279.2  neurogenin-3

    See proteins identical to NP_066279.2

    Status: REVIEWED

    Source sequence(s)
    AK313952, BC069098
    Consensus CDS
    CCDS31212.1
    UniProtKB/Swiss-Prot
    Q9Y4Z2
    Conserved Domains (1) summary
    cd00083
    Location:81140
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000010.11 

    Range
    69572035..69573454
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018921.2 

    Range
    71613524..71614943
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000142.1 

    Range
    65321715..65323132
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)