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    Kif3a kinesin family member 3A [ Mus musculus (house mouse) ]

    Gene ID: 16568, updated on 23-Aug-2016
    Official Symbol
    Kif3aprovided by MGI
    Official Full Name
    kinesin family member 3Aprovided by MGI
    Primary source
    MGI:MGI:107689
    See related
    Ensembl:ENSMUSG00000018395 Vega:OTTMUSG00000005634
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Kif3; Kifl; Kns3
    Orthologs
    Location:
    11 A5-B1; 11 31.97 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (53567192..53604248)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (53380881..53417746)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene ribosomal protein L9, pseudogene 3 Neighboring gene septin 8 Neighboring gene cyclin-like Neighboring gene RIKEN cDNA A430108G06 gene Neighboring gene interleukin 4 Neighboring gene interleukin 13

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • 111-11-71, 111-11-86

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    kinesin binding ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    spectrin binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Process Evidence Code Pubs
    anterior/posterior pattern specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell projection organization IEA
    Inferred from Electronic Annotation
    more info
     
    cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cilium morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dentate gyrus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    determination of left/right symmetry IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dorsal/ventral neural tube patterning IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    dorsal/ventral neural tube patterning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dorsal/ventral pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    epidermal stem cell homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    epidermis development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    heart development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    heart looping IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    in utero embryonic development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    inner ear receptor stereocilium organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    kidney development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    motile primary cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neural precursor cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neural tube development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nonmotile primary cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of axo-dendritic protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of establishment or maintenance of cell polarity regulating cell shape ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of intracellular protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of receptor-mediated endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    smoothened signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    axon cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    axoneme ISO
    Inferred from Sequence Orthology
    more info
     
    cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    cilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with intraciliary transport particle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    kinesin II complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    kinesin II complex ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    motile primary cilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    photoreceptor connecting cilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    primary cilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with ribbon synapse ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with spindle microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    kinesin-like protein KIF3A
    Names
    N-4 kinesin
    kinesin-II subunit
    microtubule plus end-directed kinesin motor 3A

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290805.1NP_001277734.1  kinesin-like protein KIF3A isoform 2

      See identical proteins and their annotated locations for NP_001277734.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
      Source sequence(s)
      AK053412, AK084748, AK147078, AK149180, AV356644, BB752635, BC052707, CJ157264
      Consensus CDS
      CCDS70185.1
      UniProtKB/Swiss-Prot
      P28741
      UniProtKB/TrEMBL
      Q3UF02, Q3UI47
      Related
      ENSMUSP00000056197, OTTMUSP00000005811, ENSMUST00000057330, OTTMUST00000012533
      Conserved Domains (3) summary
      pfam00225
      Location:20345
      Kinesin; Kinesin motor domain
      pfam03938
      Location:420479
      OmpH; Outer membrane protein (OmpH-like)
      cd01371
      Location:13345
      KISc_KIF3; Kinesin motor domain, kinesins II or KIF3_like proteins
    2. NM_001290806.1NP_001277735.1  kinesin-like protein KIF3A isoform 3

      See identical proteins and their annotated locations for NP_001277735.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the central coding region, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1.
      Source sequence(s)
      AK053412, AK084748, AK149180, AK169425, AV356644, BB752635, BC052707, CJ157264
      Consensus CDS
      CCDS78947.1
      UniProtKB/Swiss-Prot
      P28741
      UniProtKB/TrEMBL
      Q3TET1, Q3UF02
      Related
      ENSMUSP00000133432, OTTMUSP00000055120, ENSMUST00000173744, OTTMUST00000098169
      Conserved Domains (3) summary
      pfam00225
      Location:20345
      Kinesin; Kinesin motor domain
      pfam03938
      Location:405475
      OmpH; Outer membrane protein (OmpH-like)
      cd01371
      Location:13345
      KISc_KIF3; Kinesin motor domain, kinesins II or KIF3_like proteins
    3. NM_008443.4NP_032469.2  kinesin-like protein KIF3A isoform 1

      See identical proteins and their annotated locations for NP_032469.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK053412, AK084748, AK149180, AV356644, BB752635, BC052707, CJ157264
      Consensus CDS
      CCDS48795.1
      UniProtKB/Swiss-Prot
      P28741
      UniProtKB/TrEMBL
      Q3UF02
      Related
      ENSMUSP00000112782, OTTMUSP00000036690, ENSMUST00000120613, OTTMUST00000071553
      Conserved Domains (2) summary
      cd01371
      Location:13345
      KISc_KIF3; Kinesin motor domain, kinesins II or KIF3_like proteins
      pfam00225
      Location:20345
      Kinesin; Kinesin motor domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      53567192..53604248
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532325.3XP_006532388.1  

      UniProtKB/TrEMBL
      B1AQZ2
      Related
      ENSMUSP00000113848, OTTMUSP00000036689, ENSMUST00000118353, OTTMUST00000071552
      Conserved Domains (3) summary
      pfam00225
      Location:20345
      Kinesin; Kinesin motor domain
      pfam03938
      Location:447506
      OmpH; Outer membrane protein (OmpH-like)
      cd01371
      Location:13345
      KISc_KIF3; Kinesin motor domain, kinesins II or KIF3_like proteins
    2. XM_006532328.3XP_006532391.1  

      Conserved Domains (3) summary
      pfam00225
      Location:20345
      Kinesin; Kinesin motor domain
      pfam03938
      Location:447506
      OmpH; Outer membrane protein (OmpH-like)
      cd01371
      Location:13345
      KISc_KIF3; Kinesin motor domain, kinesins II or KIF3_like proteins
    3. XM_006532326.3XP_006532389.1  

      Conserved Domains (3) summary
      pfam00225
      Location:20345
      Kinesin; Kinesin motor domain
      pfam03938
      Location:444503
      OmpH; Outer membrane protein (OmpH-like)
      cd01371
      Location:13345
      KISc_KIF3; Kinesin motor domain, kinesins II or KIF3_like proteins