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Nfe2l2 nuclear factor, erythroid derived 2, like 2 [ Mus musculus (house mouse) ]

Gene ID: 18024, updated on 19-Sep-2014
Official Symbol
Nfe2l2provided by MGI
Official Full Name
nuclear factor, erythroid derived 2, like 2provided by MGI
Primary source
MGI:MGI:108420
Locus tag
RP23-374O4.2
See related
Ensembl:ENSMUSG00000015839; Vega:OTTMUSG00000013248
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nrf2; AI194320
See Nfe2l2 in Epigenomics, MapViewer
Location:
2 C3; 2 44.75 cM
Exon count:
5
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 2 NC_000068.7 (75675519..75704641, complement)

Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene predicted gene 13655 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 Neighboring gene RIKEN cDNA E030042O20 gene Neighboring gene uncharacterized LOC102637830 Neighboring gene uncharacterized LOC102637978

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
cellular response to hydrogen peroxide ISO
Inferred from Sequence Orthology
more info
 
cellular response to laminar fluid shear stress ISO
Inferred from Sequence Orthology
more info
 
cellular response to oxidative stress IDA
Inferred from Direct Assay
more info
 
cellular response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
 
cellular response to tumor necrosis factor ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum unfolded protein response IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell death ISO
Inferred from Sequence Orthology
more info
 
negative regulation of endothelial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of blood coagulation IMP
Inferred from Mutant Phenotype
more info
 
positive regulation of reactive oxygen species metabolic process IMP
Inferred from Mutant Phenotype
more info
 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription from RNA polymerase II promoter in response to stress ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated IGI
Inferred from Genetic Interaction
more info
PubMed 
proteasomal ubiquitin-independent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
regulation of embryonic development IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of removal of superoxide radicals IMP
Inferred from Mutant Phenotype
more info
 
regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
centrosome ISO
Inferred from Sequence Orthology
more info
 
chromatin IDA
Inferred from Direct Assay
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
 
cytoplasm IPI
Inferred from Physical Interaction
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
nuclear factor erythroid 2-related factor 2
Names
nuclear factor erythroid 2-related factor 2
NFE2-related factor 2
NF-E2-related factor 2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010902.3NP_035032.1  nuclear factor erythroid 2-related factor 2

    See proteins identical to NP_035032.1

    Status: VALIDATED

    Source sequence(s)
    AK142347, BY792550
    Consensus CDS
    CCDS16150.1
    UniProtKB/Swiss-Prot
    Q60795
    Related
    ENSMUSP00000099733, OTTMUSP00000014243, ENSMUST00000102672, OTTMUST00000032007
    Conserved Domains (2) summary
    cd12193
    Location:490534
    B_zip1; basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins
    pfam03131
    Location:460553
    bZIP_Maf; bZIP Maf transcription factor

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000068.7 

    Range
    75675519..75704641
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000024.1 

    Range
    77336615..77365680
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)