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Itga7 integrin alpha 7 [ Mus musculus (house mouse) ]

Gene ID: 16404, updated on 19-Sep-2014
Official Symbol
Itga7provided by MGI
Official Full Name
integrin alpha 7provided by MGI
Primary source
MGI:MGI:102700
See related
Ensembl:ENSMUSG00000025348
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
[a]7; alpha7
See Itga7 in Epigenomics, MapViewer
Location:
10 D3; 10 77.2 cM
Exon count:
28
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 10 NC_000076.6 (128933773..128958286)

Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene retinol dehydrogenase 5 Neighboring gene biogenesis of lysosomal organelles complex-1, subunit 1 Neighboring gene methyltransferase like 7B Neighboring gene RIKEN cDNA 9030616G12 gene Neighboring gene olfactory receptor 9

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystem (from KEGG)
    Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystemArrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart muscle disease that may result in arrhythmia, heart failure, and sudden death. The hallmark pathological findings are prog...
  • Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystem (from KEGG)
    Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystemArrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart muscle disease that may result in arrhythmia, heart failure, and sudden death. The hallmark pathological findings are prog...
  • Dilated cardiomyopathy, organism-specific biosystem (from KEGG)
    Dilated cardiomyopathy, organism-specific biosystemDilated cardiomyopathy (DCM) is a heart muscle disease characterised by dilation and impaired contraction of the left or both ventricles that results in progressive heart failure and sudden cardiac d...
  • Dilated cardiomyopathy, conserved biosystem (from KEGG)
    Dilated cardiomyopathy, conserved biosystemDilated cardiomyopathy (DCM) is a heart muscle disease characterised by dilation and impaired contraction of the left or both ventricles that results in progressive heart failure and sudden cardiac d...
  • ECM proteoglycans, organism-specific biosystem (from REACTOME)
    ECM proteoglycans, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • ECM-receptor interaction, organism-specific biosystem (from KEGG)
    ECM-receptor interaction, organism-specific biosystemThe extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell ...
  • ECM-receptor interaction, conserved biosystem (from KEGG)
    ECM-receptor interaction, conserved biosystemThe extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell ...
  • Extracellular matrix organization, organism-specific biosystem (from REACTOME)
    Extracellular matrix organization, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Focal Adhesion, organism-specific biosystem (from WikiPathways)
    Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • Focal adhesion, organism-specific biosystem (from KEGG)
    Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • Focal adhesion, conserved biosystem (from KEGG)
    Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • Hypertrophic cardiomyopathy (HCM), organism-specific biosystem (from KEGG)
    Hypertrophic cardiomyopathy (HCM), organism-specific biosystemHypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological feat...
  • Hypertrophic cardiomyopathy (HCM), conserved biosystem (from KEGG)
    Hypertrophic cardiomyopathy (HCM), conserved biosystemHypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological feat...
  • Integrin-mediated cell adhesion, organism-specific biosystem (from WikiPathways)
    Integrin-mediated cell adhesion, organism-specific biosystemIntegrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the extracellular matrix (ECM). They also play a role in cell signaling and ...
  • Laminin interactions, organism-specific biosystem (from REACTOME)
    Laminin interactions, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
    PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
    PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • Regulation of actin cytoskeleton, organism-specific biosystem (from KEGG)
    Regulation of actin cytoskeleton, organism-specific biosystem
    Regulation of actin cytoskeleton
  • Regulation of actin cytoskeleton, conserved biosystem (from KEGG)
    Regulation of actin cytoskeleton, conserved biosystem
    Regulation of actin cytoskeleton
  • XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystem (from WikiPathways)
    XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystemXPodNet is a larger version of PodNet. Interactions from STRING database have been added to PodNet to build XPodNet. Hence, not all interactions found in XPodNet do necessarily have to be curated.
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
cell adhesion molecule binding ISO
Inferred from Sequence Orthology
more info
 
integrin binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to laminin binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to laminin binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
laminin binding ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
blood vessel morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell adhesion ISO
Inferred from Sequence Orthology
more info
 
cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
heterotypic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
integrin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
regulation of cell shape IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell surface ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integrin alpha7-beta1 complex IDA
Inferred from Direct Assay
more info
PubMed 
integrin alpha7-beta1 complex IPI
Inferred from Physical Interaction
more info
PubMed 
integrin complex ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
muscle tendon junction IDA
Inferred from Direct Assay
more info
PubMed 
neuromuscular junction IDA
Inferred from Direct Assay
more info
PubMed 
sarcolemma IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
integrin alpha-7
Names
integrin alpha-7

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008398.2NP_032424.2  integrin alpha-7

    See proteins identical to NP_032424.2

    Status: VALIDATED

    Source sequence(s)
    AA712024, AC122380, BM950653, BQ030964, BQ559507, BQ933931, BY148846, CN669314, CX208029, CX209825
    Consensus CDS
    CCDS24300.1
    UniProtKB/TrEMBL
    G3X9Q1
    Related
    ENSMUSP00000096712, ENSMUST00000099112
    Conserved Domains (2) summary
    smart00191
    Location:377429
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam08441
    Location:471961
    Integrin_alpha2; Integrin alpha

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000076.6 

    Range
    128933773..128958286
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513268.1XP_006513331.1  

    Conserved Domains (2) summary
    smart00191
    Location:381433
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam08441
    Location:475965
    Integrin_alpha2; Integrin alpha
  2. XM_006513267.1XP_006513330.1  

    See proteins identical to XP_006513330.1

    UniProtKB/TrEMBL
    Q3TZS3
    Conserved Domains (2) summary
    smart00191
    Location:381433
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam08441
    Location:475965
    Integrin_alpha2; Integrin alpha
  3. XM_006513269.1XP_006513332.1  

    Conserved Domains (2) summary
    smart00191
    Location:317369
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam08441
    Location:411901
    Integrin_alpha2; Integrin alpha
  4. XM_006513270.1XP_006513333.1  

    Conserved Domains (2) summary
    smart00191
    Location:213265
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam08441
    Location:307797
    Integrin_alpha2; Integrin alpha

Alternate Mm_Celera

Genomic

  1. AC_000032.1 

    Range
    131326513..131351034
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)