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Pld2 phospholipase D2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25097, updated on 6-Jul-2014
Official Symbol
Pld2provided by RGD
Official Full Name
phospholipase D2provided by RGD
Primary source
RGD:3350
See related
Ensembl:ENSRNOG00000019604
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
Pldc
Summary
catalyzes hydrolysis of phosphatidylcholine (PC) to phosphatidic acid and choline; involved in important cellular processes such as signal transduction, membrane trafficking, and mitosis regulation [RGD, Feb 2006]
Annotation information
Annotation category: partial on reference assembly
See Pld2 in MapViewer
Location:
10q23.3-q24
Exon count :
24
Annotation release Status Assembly Chr Location
104 current Rnor_5.0 (GCF_000001895.4) 10 NC_005109.3 (56908891..56926691)

Chromosome 10 - NC_005109.3Genomic Context describing neighboring genes Neighboring gene proteasome (prosome, macropain) subunit, beta type 6 Neighboring gene translocase of outer mitochondrial membrane 7 homolog Neighboring gene misshapen-like kinase 1 Neighboring gene uncharacterized LOC102547201 Neighboring gene uncharacterized LOC102547121

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • EGFR1 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    EGFR1 Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
  • Endocytosis, organism-specific biosystem (from KEGG)
    Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Endocytosis, conserved biosystem (from KEGG)
    Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Ether lipid metabolism, organism-specific biosystem (from KEGG)
    Ether lipid metabolism, organism-specific biosystem
    Ether lipid metabolism
  • Ether lipid metabolism, conserved biosystem (from KEGG)
    Ether lipid metabolism, conserved biosystem
    Ether lipid metabolism
  • Fc gamma R-mediated phagocytosis, organism-specific biosystem (from KEGG)
    Fc gamma R-mediated phagocytosis, organism-specific biosystemPhagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes ta...
  • Fc gamma R-mediated phagocytosis, conserved biosystem (from KEGG)
    Fc gamma R-mediated phagocytosis, conserved biosystemPhagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes ta...
  • Glutamatergic synapse, organism-specific biosystem (from KEGG)
    Glutamatergic synapse, organism-specific biosystemGlutamate is the major excitatory neurotransmitter in the mammalian central nervous system(CNS). Glutamate is packaged into synaptic vesicles in the presynaptic terminal. Once released into the synap...
  • Glutamatergic synapse, conserved biosystem (from KEGG)
    Glutamatergic synapse, conserved biosystemGlutamate is the major excitatory neurotransmitter in the mammalian central nervous system(CNS). Glutamate is packaged into synaptic vesicles in the presynaptic terminal. Once released into the synap...
  • Glycerophospholipid metabolism, organism-specific biosystem (from KEGG)
    Glycerophospholipid metabolism, organism-specific biosystem
    Glycerophospholipid metabolism
  • Glycerophospholipid metabolism, conserved biosystem (from KEGG)
    Glycerophospholipid metabolism, conserved biosystem
    Glycerophospholipid metabolism
  • GnRH signaling pathway, organism-specific biosystem (from KEGG)
    GnRH signaling pathway, organism-specific biosystemGonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnR...
  • GnRH signaling pathway, conserved biosystem (from KEGG)
    GnRH signaling pathway, conserved biosystemGonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnR...
  • Ras signaling pathway, organism-specific biosystem (from KEGG)
    Ras signaling pathway, organism-specific biosystemThe Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras prote...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
N-acylphosphatidylethanolamine-specific phospholipase D activity IEA
Inferred from Electronic Annotation
more info
 
catalytic activity IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
 
phospholipase D activity IDA
Inferred from Direct Assay
more info
PubMed 
phospholipase D activity ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase C binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G-protein coupled receptor internalization IEA
Inferred from Electronic Annotation
more info
 
G-protein coupled receptor internalization ISO
Inferred from Sequence Orthology
more info
 
neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
phospholipid catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of mast cell degranulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of phosphatidylinositol 3-kinase signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of receptor-mediated endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
receptor-mediated endocytosis ISO
Inferred from Sequence Orthology
more info
 
response to hydrogen peroxide IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to hypoxia IDA
Inferred from Direct Assay
more info
PubMed 
response to organic cyclic compound IDA
Inferred from Direct Assay
more info
PubMed 
response to peptide hormone IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
brush border membrane IEA
Inferred from Electronic Annotation
more info
 
brush border membrane ISO
Inferred from Sequence Orthology
more info
 
caveola IDA
Inferred from Direct Assay
more info
PubMed 
lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
sarcolemma IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
phospholipase D2
Names
phospholipase D2
PLD 2
PLD1C
rPLD2
choline phosphatase 2
phospholipase D gene 2
phosphatidylcholine-hydrolyzing phospholipase D2
NP_150641.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033299.2NP_150641.2  phospholipase D2

    See proteins identical to NP_150641.2

    Status: PROVISIONAL

    Source sequence(s)
    D88672
    UniProtKB/Swiss-Prot
    P70498
    Related
    ENSRNOP00000053831, ENSRNOT00000056998
    Conserved Domains (4) summary
    cd07297
    Location:62192
    Blast Score: 646
    PX_PLD2; The phosphoinositide binding Phox Homology domain of Phospholipase D2
    PLN02866
    Location:67918
    Blast Score: 1600
    PLN02866; phospholipase D
    cd01254
    Location:180309
    Blast Score: 445
    PH_PLD; Phospholipase D pleckstrin homology (PH) domain
    cl15239
    Location:614795
    Blast Score: 946
    PLDc_SF; Catalytic domain of phospholipase D superfamily proteins

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_5.0 Primary Assembly

Genomic

  1. NC_005109.3 

    Range
    56908891..56926691
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000078.1 

    Range
    54402188..54419867
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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