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Drd3 dopamine receptor D3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29238, updated on 8-Dec-2014
Official Symbol
Drd3provided by RGD
Official Full Name
dopamine receptor D3provided by RGD
Primary source
RGD:2521
See related
Ensembl:ENSRNOG00000026772
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Summary
may be involved in facilitating the effects of antipsychotic drugs and drug treatments for Parkinson's disease [RGD, Feb 2006]
See Drd3 in MapViewer
Location:
11q21
Exon count:
8
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (61822077..61883223, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 11 NC_005110.3 (60955136..61016058, complement)

Chromosome 11 - NC_005110.4Genomic Context describing neighboring genes Neighboring gene similar to KIAA1407 Neighboring gene queuine tRNA-ribosyltransferase domain containing 1 Neighboring gene uncharacterized LOC103693574 Neighboring gene T cell immunoreceptor with Ig and ITIM domains

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
D1 dopamine receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
dopamine binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
dopamine neurotransmitter receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
dopamine neurotransmitter receptor activity TAS
Traceable Author Statement
more info
PubMed 
dopamine neurotransmitter receptor activity, coupled via Gi/Go IDA
Inferred from Direct Assay
more info
PubMed 
dopamine neurotransmitter receptor activity, coupled via Gi/Go ISO
Inferred from Sequence Orthology
more info
 
drug binding IDA
Inferred from Direct Assay
more info
PubMed 
drug binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G-protein coupled receptor internalization IDA
Inferred from Direct Assay
more info
PubMed 
G-protein coupled receptor internalization ISO
Inferred from Sequence Orthology
more info
 
G-protein coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
G-protein coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acid secretion IDA
Inferred from Direct Assay
more info
PubMed 
adenylate cyclase-activating dopamine receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
adenylate cyclase-activating dopamine receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
adenylate cyclase-inhibiting dopamine receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
adenylate cyclase-inhibiting dopamine receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
arachidonic acid secretion IEA
Inferred from Electronic Annotation
more info
 
arachidonic acid secretion ISO
Inferred from Sequence Orthology
more info
 
behavioral response to cocaine IMP
Inferred from Mutant Phenotype
more info
PubMed 
behavioral response to cocaine ISO
Inferred from Sequence Orthology
more info
 
cellular calcium ion homeostasis IEA
Inferred from Electronic Annotation
more info
 
cellular calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
circadian regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
circadian regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
dopamine receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
dopamine receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
gastric emptying IMP
Inferred from Mutant Phenotype
more info
PubMed 
locomotory behavior IEA
Inferred from Electronic Annotation
more info
 
locomotory behavior ISO
Inferred from Sequence Orthology
more info
 
NOT locomotory behavior ISO
Inferred from Sequence Orthology
more info
 
musculoskeletal movement, spinal reflex action IEA
Inferred from Electronic Annotation
more info
 
musculoskeletal movement, spinal reflex action ISO
Inferred from Sequence Orthology
more info
 
negative regulation of adenylate cyclase activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of adenylate cyclase activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of blood pressure IEA
Inferred from Electronic Annotation
more info
 
negative regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
 
negative regulation of dopamine receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of dopamine receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of oligodendrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of oligodendrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein kinase B signaling IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein secretion IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein secretion ISO
Inferred from Sequence Orthology
more info
 
negative regulation of sodium:proton antiporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cytokinesis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cytokinesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of dopamine receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of dopamine receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of mitosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of renal sodium excretion IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
prepulse inhibition IEA
Inferred from Electronic Annotation
more info
 
prepulse inhibition ISO
Inferred from Sequence Orthology
more info
 
regulation of blood volume by renin-angiotensin IEA
Inferred from Electronic Annotation
more info
 
regulation of blood volume by renin-angiotensin ISO
Inferred from Sequence Orthology
more info
 
regulation of cAMP metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cAMP metabolic process ISO
Inferred from Sequence Orthology
more info
 
regulation of circadian sleep/wake cycle, sleep IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of dopamine secretion IEA
Inferred from Electronic Annotation
more info
 
regulation of dopamine secretion ISO
Inferred from Sequence Orthology
more info
 
regulation of lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
regulation of lipid metabolic process ISO
Inferred from Sequence Orthology
more info
 
regulation of locomotion IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of locomotion involved in locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
regulation of multicellular organism growth ISO
Inferred from Sequence Orthology
more info
 
response to amphetamine IEA
Inferred from Electronic Annotation
more info
 
response to amphetamine ISO
Inferred from Sequence Orthology
more info
 
response to cocaine ISO
Inferred from Sequence Orthology
more info
 
response to drug IDA
Inferred from Direct Assay
more info
PubMed 
response to drug TAS
Traceable Author Statement
more info
PubMed 
response to ethanol IEA
Inferred from Electronic Annotation
more info
 
response to ethanol ISO
Inferred from Sequence Orthology
more info
 
NOT response to ethanol ISO
Inferred from Sequence Orthology
more info
 
response to histamine IEA
Inferred from Electronic Annotation
more info
 
response to histamine ISO
Inferred from Sequence Orthology
more info
 
response to morphine IEA
Inferred from Electronic Annotation
more info
 
response to morphine ISO
Inferred from Sequence Orthology
more info
 
synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
synaptic transmission, dopaminergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
visual learning IEA
Inferred from Electronic Annotation
more info
 
visual learning ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
apical part of cell IDA
Inferred from Direct Assay
more info
PubMed 
cell projection IDA
Inferred from Direct Assay
more info
PubMed 
endocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
D(3) dopamine receptor
Names
D(3) dopamine receptor
dopamine D3 receptor
dopaminergic receptor D3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017140.1NP_058836.1  D(3) dopamine receptor

    See proteins identical to NP_058836.1

    Status: PROVISIONAL

    Source sequence(s)
    X53944
    UniProtKB/Swiss-Prot
    P19020
    Related
    ENSRNOP00000031550, ENSRNOT00000029474
    Conserved Domains (2) summary
    pfam00001
    Location:52429
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam10320
    Location:44225
    7TM_GPCR_Srsx; Serpentine type 7TM GPCR chemoreceptor Srsx

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005110.4 

    Range
    61822077..61883223
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006248313.2XP_006248375.2  

    Conserved Domains (2) summary
    pfam00001
    Location:84461
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam10320
    Location:76257
    7TM_GPCR_Srsx; Serpentine type 7TM GPCR chemoreceptor Srsx

Alternate Rn_Celera

Genomic

  1. AC_000079.1 

    Range
    56432639..56484538
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)