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    Ube3a ubiquitin protein ligase E3A [ Mus musculus (house mouse) ]

    Gene ID: 22215, updated on 17-Sep-2016
    Official Symbol
    Ube3aprovided by MGI
    Official Full Name
    ubiquitin protein ligase E3Aprovided by MGI
    Primary source
    MGI:MGI:105098
    See related
    Ensembl:ENSMUSG00000025326 Vega:OTTMUSG00000055999
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hpve6a; mKIAA4216; 4732496B02; 5830462N02Rik; A130086L21Rik
    Orthologs
    Location:
    7 C; 7 33.95 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (59228750..59306733)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (66484120..66562097)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 39020 Neighboring gene predicted gene 9375 Neighboring gene high mobility group box 2 pseudogene Neighboring gene RIKEN cDNA C230091D08 gene Neighboring gene predicted gene, 22496

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Androgen Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Androgen Receptor Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
    • Tryptophan metabolism, organism-specific biosystem (from WikiPathways)
      Tryptophan metabolism, organism-specific biosystem
      Tryptophan metabolism
    • Ubiquitin mediated proteolysis, organism-specific biosystem (from KEGG)
      Ubiquitin mediated proteolysis, organism-specific biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
    • Ubiquitin mediated proteolysis, conserved biosystem (from KEGG)
      Ubiquitin mediated proteolysis, conserved biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
    • Viral carcinogenesis, organism-specific biosystem (from KEGG)
      Viral carcinogenesis, organism-specific biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
    • Viral carcinogenesis, conserved biosystem (from KEGG)
      Viral carcinogenesis, conserved biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • KIAA4216

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    coenzyme F420-0 gamma-glutamyl ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    coenzyme F420-2 alpha-glutamyl ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein-glutamic acid ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein-glycine ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein-glycine ligase activity, elongating IEA
    Inferred from Electronic Annotation
    more info
     
    protein-glycine ligase activity, initiating IEA
    Inferred from Electronic Annotation
    more info
     
    ribosomal S6-glutamic acid ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    tubulin-glutamic acid ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    tubulin-glycine ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    androgen receptor signaling pathway IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ovarian follicle development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of phosphatidylinositol 3-kinase signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    prostate gland growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    protein autoubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein ubiquitination involved in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    regulation of circadian rhythm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of circadian rhythm ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    rhythmic process IEA
    Inferred from Electronic Annotation
    more info
     
    sperm entry IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    proteasome complex IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    ubiquitin-protein ligase E3A
    Names
    E6-AP ubiquitin protein ligase
    oncogenic protein-associated protein E6-AP
    ubiquitin conjugating enzyme E3A
    NP_001029134.1
    NP_035798.2
    NP_766598.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033962.1NP_001029134.1  ubiquitin-protein ligase E3A isoform 3

      See identical proteins and their annotated locations for NP_001029134.1

      Status: VALIDATED

      Source sequence(s)
      AK220549, BY301312
      Consensus CDS
      CCDS80733.1
      UniProtKB/TrEMBL
      Q5DTH1
      Related
      ENSMUSP00000103161, OTTMUSP00000072827, ENSMUST00000107537, OTTMUST00000138561
      Conserved Domains (3) summary
      smart00119
      Location:524846
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:497847
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam16558
      Location:660
      AZUL; Amino-terminal Zinc-binding domain of ubiquitin ligase E3A
    2. NM_011668.2NP_035798.2  ubiquitin-protein ligase E3A isoform 2

      See identical proteins and their annotated locations for NP_035798.2

      Status: VALIDATED

      Source sequence(s)
      AK220549, BY301312, CD352481
      Consensus CDS
      CCDS39973.1
      UniProtKB/Swiss-Prot
      O08759
      UniProtKB/TrEMBL
      Q5DTH1
      Related
      ENSMUSP00000143859, OTTMUSP00000072811, ENSMUST00000200758, OTTMUST00000138507
      Conserved Domains (3) summary
      smart00119
      Location:545867
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:518868
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam16558
      Location:2781
      AZUL; Amino-terminal Zinc-binding domain of ubiquitin ligase E3A
    3. NM_173010.3NP_766598.1  ubiquitin-protein ligase E3A isoform 1

      See identical proteins and their annotated locations for NP_766598.1

      Status: PROVISIONAL

      Source sequence(s)
      AC167971
      Consensus CDS
      CCDS80734.1
      UniProtKB/Swiss-Prot
      O08759
      Related
      ENSMUSP00000143962, OTTMUSP00000072826, ENSMUST00000202945, OTTMUST00000138560
      Conserved Domains (2) summary
      cd00078
      Location:497762
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam16558
      Location:660
      AZUL; Amino-terminal Zinc-binding domain of ubiquitin ligase E3A

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      59228750..59306733
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006540799.3XP_006540862.1  

      See identical proteins and their annotated locations for XP_006540862.1

      UniProtKB/Swiss-Prot
      O08759
      Conserved Domains (3) summary
      smart00119
      Location:545867
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:518868
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam16558
      Location:2781
      AZUL; Amino-terminal Zinc-binding domain of ubiquitin ligase E3A
    2. XM_006540800.3XP_006540863.1  

      See identical proteins and their annotated locations for XP_006540863.1

      Conserved Domains (3) summary
      smart00119
      Location:533855
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:506856
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam16558
      Location:1569
      AZUL; Amino-terminal Zinc-binding domain of ubiquitin ligase E3A
    3. XM_006540801.3XP_006540864.1  

      See identical proteins and their annotated locations for XP_006540864.1

      Conserved Domains (3) summary
      smart00119
      Location:533855
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:506856
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam16558
      Location:1569
      AZUL; Amino-terminal Zinc-binding domain of ubiquitin ligase E3A
    4. XM_011250847.2XP_011249149.1  

      See identical proteins and their annotated locations for XP_011249149.1

      UniProtKB/Swiss-Prot
      O08759
      Conserved Domains (3) summary
      smart00119
      Location:524846
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:497847
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam16558
      Location:660
      AZUL; Amino-terminal Zinc-binding domain of ubiquitin ligase E3A
    5. XM_017322125.1XP_017177614.1  

      Conserved Domains (3) summary
      smart00119
      Location:545867
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:518868
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam16558
      Location:2781
      AZUL; Amino-terminal Zinc-binding domain of ubiquitin ligase E3A
    6. XM_006540803.3XP_006540866.1  

      Conserved Domains (2) summary
      smart00119
      Location:485807
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:458808
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
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