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NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) [ Homo sapiens (human) ]

Gene ID: 2908, updated on 21-Mar-2015
Official Symbol
NR3C1provided by HGNC
Official Full Name
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)provided by HGNC
Primary source
HGNC:HGNC:7978
See related
Ensembl:ENSG00000113580; HPRD:00679; MIM:138040; Vega:OTTHUMG00000129677
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GR; GCR; GRL; GCCR; GCRST
Summary
This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011]
Orthologs
See NR3C1 in MapViewer
Location:
5q31.3
Exon count:
16
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 5 NC_000005.10 (143277931..143435512, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (142657496..143113322, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 26 Neighboring gene ARHGAP26 antisense RNA 1 Neighboring gene ARHGAP26 intronic transcript 1 Neighboring gene uncharacterized LOC105378206 Neighboring gene ribosomal protein L7 pseudogene 21 Neighboring gene uncharacterized LOC105378207 Neighboring gene uncharacterized LOC105378208

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Associated conditions

Description Tests
Glucocorticoid resistance, generalized
MedGen: CN205763 OMIM: 615962 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Genome-wide meta-analysis identifies new susceptibility loci for migraine.
NHGRI GWA Catalog
Genomewide pharmacogenomic study of metabolic side effects to antipsychotic drugs.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr Glucocorticoid receptor (GR) agonists, dexamethasone (Dex) and medroxyprogesterone acetate (MPA), enhance HIV-1 Vpr peptide (amino acids 52-96)-mediated apoptosis of CD4+ T-cells in a GR-dependent manner PubMed
vpr HIV-1 Vpr leucine residues mediate Vpr-Glucocorticoid Receptor (GR) interaction and promoter transactivation; mutation at residue L22 results in 8- to 11-fold higher GRE and HIV-1 LTR transactivation, while L42 and L67 mutants showed reduced activation PubMed
vpr HIV-1 Vpr activates transcription of glucocorticoid-responsive promoters by binding directly to p300/CBP co-activators, forming a stable complex with p300 and interacting with ligand-bound glucocorticoid receptor PubMed
vpr HIV-1 Vpr potentiates the trans-activation, but not the trans-repression, properties of the glucocorticoid receptor on NF-kappa B and activating protein 1-regulated simple promoters PubMed
vpr HIV-1 Vpr (amino acids 22-26 and 64-68) binds to and activates glucocorticoid receptor (GR) and transactivates the HIV-1 LTR promoter through the host GR pathway PubMed
vpr HIV-1 Vpr targets the glucocorticoid receptor type II complex through an interaction with Vpr interacting protein 1 (Rip-1), a 41 kDa cytosolic protein that binds to Vpr and in a complex with the human glucocorticoid receptor PubMed
vpr HIV-1 Vpr affects the gene expression of glucocorticoid-regulated genes (IL-12, CD44, Toll-like receptor 4 and indolamine 2,3-dioxygenase, macrophage receptor with collagenous structure, and thrombospondin 1) through activation of the GR pathway PubMed
vpr Studies suggest effects of HIV-1 Vpr on cytokine expression (IL-2, IL-10, IL-12, TNFalpha and IL-4) and T-cell proliferation may be mediated through activation of the glucocorticoid receptor pathway PubMed
vpr Interaction of HIV-1 Vpr and hVIP/mov34 may be involved in the activation of glucocorticoid receptor by Vpr PubMed
vpr Transcription factors TFIIH, CDK7, Cyclin H, and MAT1 enhance HIV-1 Vpr activation of glucocorticoid receptor PubMed
vpr HIV-1 Vpr synergistically enhances SRC-1 ligand-activated glucocorticoid receptor activity PubMed
vpr HIV-1 Vpr (amino acids 1-35) binds to TFIID, an interaction that is associated with the ability of Vpr to stimulate transcription through the glucocorticoid receptor pathway PubMed
vpr Specific binding of HIV-1 Vpr (amino acids 15-35) to TFIIB (amino acids 52-55) causes a conformational change in TFIIB and is correlated with the ability of Vpr to stimulate transcription through the glucocorticoid receptor pathway PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
adrenal gland development IEA
Inferred from Electronic Annotation
more info
 
cellular response to steroid hormone stimulus IDA
Inferred from Direct Assay
more info
PubMed 
chromatin modification IEA
Inferred from Electronic Annotation
more info
 
gene expression TAS
Traceable Author Statement
more info
 
glucocorticoid mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
glucocorticoid metabolic process IEA
Inferred from Electronic Annotation
more info
 
glucocorticoid receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
mammary gland duct morphogenesis IEA
Inferred from Electronic Annotation
more info
 
maternal behavior IEA
Inferred from Electronic Annotation
more info
 
negative regulation of glucocorticoid mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
regulation of glucocorticoid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
regulation of gluconeogenesis IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
transcription from RNA polymerase II promoter TAS
Traceable Author Statement
more info
PubMed 
transcription initiation from RNA polymerase II promoter TAS
Traceable Author Statement
more info
 
transcription, DNA-templated TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
 
cytosol IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial matrix TAS
Traceable Author Statement
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
glucocorticoid receptor
Names
glucocorticoid receptor
glucocorticoid nuclear receptor variant 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_009062.1 RefSeqGene

    Range
    5001..162582
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000176.2NP_000167.1  glucocorticoid receptor isoform alpha

    See proteins identical to NP_000167.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript, and encodes the predominant physiological isoform (alpha, also known as GRalpha or GR-A). Variants 1-5 encode the same isoform.
    Source sequence(s)
    AC004782, AC091925, BX648553, X03225, X03348
    Consensus CDS
    CCDS4278.1
    UniProtKB/TrEMBL
    F1D8N4
    UniProtKB/Swiss-Prot
    P04150
    Related
    ENSP00000377977, OTTHUMP00000160085, ENST00000394464, OTTHUMT00000251880
    Conserved Domains (3) summary
    cd07076
    Location:531777
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:417494
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:26401
    GCR; Glucocorticoid receptor
  2. NM_001018074.1NP_001018084.1  glucocorticoid receptor isoform alpha

    See proteins identical to NP_001018084.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternative 5' terminal non-coding exon, thus has a different 5' UTR compared to variant 1. Variants 1-5 encode the same isoform (alpha).
    Source sequence(s)
    AC004782, AC091925, X03225
    Consensus CDS
    CCDS4278.1
    UniProtKB/TrEMBL
    F1D8N4
    UniProtKB/Swiss-Prot
    P04150
    Conserved Domains (3) summary
    cd07076
    Location:531777
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:417494
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:26401
    GCR; Glucocorticoid receptor
  3. NM_001018075.1NP_001018085.1  glucocorticoid receptor isoform alpha

    See proteins identical to NP_001018085.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternative 5' terminal non-coding exon, thus has a different 5' UTR compared to variant 1. Variants 1-5 encode the same isoform (alpha)
    Source sequence(s)
    AC004782, AC091925, X03225
    Consensus CDS
    CCDS4278.1
    UniProtKB/TrEMBL
    F1D8N4
    UniProtKB/Swiss-Prot
    P04150
    Conserved Domains (3) summary
    cd07076
    Location:531777
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:417494
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:26401
    GCR; Glucocorticoid receptor
  4. NM_001018076.1NP_001018086.1  glucocorticoid receptor isoform alpha

    See proteins identical to NP_001018086.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains an alternative 5' terminal non-coding exon, thus has a different 5' UTR compared to variant 1. Variants 1-5 encode the same isoform (alpha).
    Source sequence(s)
    AC004782, BF966114, X03225
    Consensus CDS
    CCDS4278.1
    UniProtKB/TrEMBL
    F1D8N4
    UniProtKB/Swiss-Prot
    P04150
    Conserved Domains (3) summary
    cd07076
    Location:531777
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:417494
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:26401
    GCR; Glucocorticoid receptor
  5. NM_001018077.1NP_001018087.1  glucocorticoid receptor isoform alpha

    See proteins identical to NP_001018087.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains an alternative 5' terminal non-coding exon, thus has a different 5' UTR compared to variant 1. Variants 1-5 encode the same isoform (alpha).
    Source sequence(s)
    AC004782, AC091925, X03225
    Consensus CDS
    CCDS4278.1
    UniProtKB/TrEMBL
    F1D8N4
    UniProtKB/Swiss-Prot
    P04150
    Related
    ENSP00000343205, ENST00000343796
    Conserved Domains (3) summary
    cd07076
    Location:531777
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:417494
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:26401
    GCR; Glucocorticoid receptor
  6. NM_001020825.1NP_001018661.1  glucocorticoid receptor isoform beta

    See proteins identical to NP_001018661.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses an alternate acceptor splice site at the 3' terminal exon compared to variant 1. This results in a frame-shift and a shorter isoform (beta, also known as GRbeta) with a distinct C-terminus compared to isoform alpha. This isoform resides primarily in the nucleus, lacks hormone-binding activity, and has a dominant negative effect on the action of isoform alpha (PMID:8621628).
    Source sequence(s)
    AC004782, AC091925, X03348
    Consensus CDS
    CCDS47298.1
    UniProtKB/TrEMBL
    E5KQF5
    UniProtKB/Swiss-Prot
    P04150
    Related
    ENSP00000387672, OTTHUMP00000222851, ENST00000415690, OTTHUMT00000370825
    Conserved Domains (3) summary
    cd07172
    Location:417494
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:26401
    GCR; Glucocorticoid receptor
    cl11397
    Location:531729
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
  7. NM_001024094.1NP_001019265.1  glucocorticoid receptor isoform gamma

    See proteins identical to NP_001019265.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) uses an alternate in-frame donor splice site at one of the coding exons compared to variant 1. This results in an isoform (gamma) that is 1 aa longer than isoform alpha. The insertion of an additional amino acid (arginine) in the DNA binding domain has been reported to decrease transcriptional activation by the glucocorticoid receptor (PMID:10566686).
    Source sequence(s)
    AC004782, AC091925, U01351
    Consensus CDS
    CCDS34258.1
    UniProtKB/TrEMBL
    E5KQF6
    UniProtKB/Swiss-Prot
    P04150
    Conserved Domains (3) summary
    cd07076
    Location:532778
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:417495
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:26401
    GCR; Glucocorticoid receptor
  8. NM_001204258.1NP_001191187.1  glucocorticoid receptor isoform alpha-B

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes multiple functional isoforms resulting from the use of alternate in-frame, translation initiation codons (PMID:15866175). This RefSeq represents a shorter isoform (alpha-B, also known as GR-B) compared to isoform alpha, and is derived from the use of a downstream AUG (at nt 571-573).
    Source sequence(s)
    AC004782, AC091925, CA425706, U01351, X03225
    UniProtKB/Swiss-Prot
    P04150
    Conserved Domains (3) summary
    cd07076
    Location:505751
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:391468
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:1375
    GCR; Glucocorticoid receptor
  9. NM_001204259.1NP_001191188.1  glucocorticoid receptor isoform alpha-C1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes multiple functional isoforms resulting from the use of alternate in-frame, translation initiation codons (PMID:15866175). This RefSeq represents a shorter isoform (alpha-C1, also known as GR-C1) compared to isoform alpha, and is derived from the use of a downstream AUG (at nt 748-750).
    Source sequence(s)
    AC004782, AC091925, CA425706, U01351, X03225
    UniProtKB/Swiss-Prot
    P04150
    Conserved Domains (3) summary
    cd07076
    Location:446692
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:332409
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:1316
    GCR; Glucocorticoid receptor
  10. NM_001204260.1NP_001191189.1  glucocorticoid receptor isoform alpha-C2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes multiple functional isoforms resulting from the use of alternate in-frame, translation initiation codons (PMID:15866175). This RefSeq represents a shorter isoform (alpha-C2, also known as GR-C2) compared to isoform alpha, and is derived from the use of a downstream AUG (at nt 760-762).
    Source sequence(s)
    AC004782, AC091925, CA425706, U01351, X03225
    UniProtKB/Swiss-Prot
    P04150
    Conserved Domains (3) summary
    cd07076
    Location:442688
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:328405
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:1312
    GCR; Glucocorticoid receptor
  11. NM_001204261.1NP_001191190.1  glucocorticoid receptor isoform alpha-C3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes multiple functional isoforms resulting from the use of alternative in-frame, translation initiation codons (PMID:15866175). This RefSeq represents a shorter isoform (alpha-C3, also known as GR-C3) compared to isoform alpha, and is derived from the use of a downstream AUG (at nt 784-786).
    Source sequence(s)
    AC004782, AC091925, CA425706, U01351, X03225
    UniProtKB/Swiss-Prot
    P04150
    Conserved Domains (3) summary
    cd07076
    Location:434680
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:320397
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:1304
    GCR; Glucocorticoid receptor
  12. NM_001204262.1NP_001191191.1  glucocorticoid receptor isoform alpha-D1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes multiple functional isoforms resulting from the use of alternate in-frame, translation initiation codons (PMID:15866175). This RefSeq represents a shorter isoform (alpha-D1, also known as GR-D1) compared to isoform alpha, and is derived from the use of a downstream AUG (at nt 1438-1440).
    Source sequence(s)
    AC004782, AC091925, CA425706, U01351, X03225
    UniProtKB/Swiss-Prot
    P04150
    Conserved Domains (3) summary
    cd07076
    Location:216462
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:102179
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:186
    GCR; Glucocorticoid receptor
  13. NM_001204263.1NP_001191192.1  glucocorticoid receptor isoform alpha-D2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes multiple functional isoforms resulting from the use of alternate in-frame, translation initiation codons (PMID:15866175). This RefSeq represents a shorter isoform (alpha-D2, also known as GR-D2) compared to isoform alpha, and is derived from the use of a downstream AUG (at nt 1483-1485).
    Source sequence(s)
    AC004782, AC091925, CA425706, U01351, X03225
    UniProtKB/Swiss-Prot
    P04150
    Conserved Domains (3) summary
    cd07076
    Location:201447
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:87164
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:171
    GCR; Glucocorticoid receptor
  14. NM_001204264.1NP_001191193.1  glucocorticoid receptor isoform alpha-D3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes multiple functional isoforms resulting from the use of alternate in-frame, translation initiation codons (PMID:15866175). This RefSeq represents a shorter isoform (alpha-D3, also known as GR-D3) compared to isoform alpha, and is derived from the use of a downstream AUG (at nt 1498-1500).
    Source sequence(s)
    AC004782, AC091925, CA425706, U01351, X03225
    UniProtKB/Swiss-Prot
    P04150
    Conserved Domains (3) summary
    cd07076
    Location:196442
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:82159
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:166
    GCR; Glucocorticoid receptor
  15. NM_001204265.1NP_001191194.1  glucocorticoid receptor isoform GR-P

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8, also known as GR-P) is missing 2 exons from the 3' end, and has a different 3' end compared to variant 1. This results in an isoform (GR-P) with a shorter and unique C-terminus compared to isoform alpha. The function of the encoded protein is not known, however, this variant is highly expressed in cells that are resistant to glucocorticoids, and may act to modulate glucocorticoid responsiveness (PMIDs:7796394, 11358809).
    Source sequence(s)
    AA737284, AC091925, BF244382, U01351, U25029
    Conserved Domains (3) summary
    cd07172
    Location:417494
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:26401
    GCR; Glucocorticoid receptor
    cl11397
    Location:531674
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p2 Primary Assembly

    Range
    143277931..143435512
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005268422.2XP_005268479.1  

    See proteins identical to XP_005268479.1

    UniProtKB/TrEMBL
    E5KQF6
    UniProtKB/Swiss-Prot
    P04150
    Conserved Domains (3) summary
    cd07076
    Location:532778
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:417495
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:26401
    GCR; Glucocorticoid receptor
  2. XM_005268419.2XP_005268476.1  

    See proteins identical to XP_005268476.1

    UniProtKB/TrEMBL
    E5KQF6
    UniProtKB/Swiss-Prot
    P04150
    Conserved Domains (3) summary
    cd07076
    Location:532778
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:417495
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:26401
    GCR; Glucocorticoid receptor
  3. XM_005268423.2XP_005268480.1  

    See proteins identical to XP_005268480.1

    UniProtKB/TrEMBL
    E5KQF6
    UniProtKB/Swiss-Prot
    P04150
    Conserved Domains (3) summary
    cd07076
    Location:532778
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:417495
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:26401
    GCR; Glucocorticoid receptor
  4. XM_005268420.3XP_005268477.1  

    See proteins identical to XP_005268477.1

    UniProtKB/TrEMBL
    E5KQF6
    UniProtKB/Swiss-Prot
    P04150
    Conserved Domains (3) summary
    cd07076
    Location:532778
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:417495
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:26401
    GCR; Glucocorticoid receptor
  5. XM_011537637.1XP_011535939.1  

    See proteins identical to XP_011535939.1

    Conserved Domains (2) summary
    cd07076
    Location:134380
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:2097
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
  6. XM_011537636.1XP_011535938.1  

    Conserved Domains (1) summary
    pfam02155
    Location:26394
    GCR; Glucocorticoid receptor

Alternate CHM1_1.1

Genomic

  1. NC_018916.2 Alternate CHM1_1.1

    Range
    142091205..142248804
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)