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CDH16 cadherin 16, KSP-cadherin [ Homo sapiens (human) ]

Gene ID: 1014, updated on 8-Feb-2015
Official Symbol
CDH16provided by HGNC
Official Full Name
cadherin 16, KSP-cadherinprovided by HGNC
Primary source
HGNC:HGNC:1755
See related
Ensembl:ENSG00000166589; HPRD:11929; MIM:603118; Vega:OTTHUMG00000137518
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. Mapped to a previously identified cluster of cadherin genes on chromosome 16q22.1, the gene localizes with superfamily members CDH1, CDH3, CDH5, CDH8 and CDH11. The protein consists of an extracellular domain containing 6 cadherin domains, a transmembrane region and a truncated cytoplasmic domain but lacks the prosequence and tripeptide HAV adhesion recognition sequence typical of most classical cadherins. Expression is exclusively in kidney, where the protein functions as the principal mediator of homotypic cellular recognition, playing a role in the morphogenic direction of tissue development. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011]
Orthologs
See CDH16 in MapViewer
Location:
16q22.1
Exon count:
19
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 16 NC_000016.10 (66908122..66918984, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (66942025..66952887, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene pyruvate dehyrogenase phosphatase catalytic subunit 2 Neighboring gene uncharacterized LOC101927816 Neighboring gene Ras-related associated with diabetes Neighboring gene family with sequence similarity 96, member B

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IEA
Inferred from Electronic Annotation
more info
 
cell adhesion TAS
Traceable Author Statement
more info
PubMed 
homophilic cell adhesion via plasma membrane adhesion molecules IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular vesicular exosome IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
cadherin-16
Names
cadherin-16
KSP-cadherin
kidney-specific cadherin

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001204744.1NP_001191673.1  cadherin-16 isoform 2 precursor

    See proteins identical to NP_001191673.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame segment in the 3' coding region, as compared to variant 1. The resulting isoform (2) lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    AY358911, BC027912, DC361453
    Consensus CDS
    CCDS56002.1
    UniProtKB/Swiss-Prot
    O75309
    Related
    ENSP00000377619, OTTHUMP00000174815, ENST00000394055, OTTHUMT00000268840
    Conserved Domains (1) summary
    cd11304
    Location:342445
    Cadherin_repeat; Cadherin tandem repeat domain
  2. NM_001204745.1NP_001191674.1  cadherin-16 isoform 3 precursor

    See proteins identical to NP_001191674.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame segment in the 3' coding region, as compared to variant 1. The resulting isoform (3) lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    AK298255, BC027912, DC361453
    Consensus CDS
    CCDS58471.1
    UniProtKB/Swiss-Prot
    O75309
    Related
    ENSP00000454784, OTTHUMP00000249751, ENST00000565796, OTTHUMT00000421378
    Conserved Domains (1) summary
    cd11304
    Location:342445
    Cadherin_repeat; Cadherin tandem repeat domain
  3. NM_001204746.1NP_001191675.1  cadherin-16 isoform 4 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an in-frame segment in the 5' coding region, as compared to variant 1. The resulting isoform (4) lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    AK225544, DC361453
    Consensus CDS
    CCDS58472.1
    UniProtKB/Swiss-Prot
    O75309
    Related
    ENSP00000455263, OTTHUMP00000249749, ENST00000568632, OTTHUMT00000421376
    Conserved Domains (1) summary
    cd11304
    Location:245348
    Cadherin_repeat; Cadherin tandem repeat domain
  4. NM_004062.3NP_004053.1  cadherin-16 isoform 1 precursor

    See proteins identical to NP_004053.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AF016272, BC027912, DC361453
    Consensus CDS
    CCDS10823.1
    UniProtKB/Swiss-Prot
    O75309
    Related
    ENSP00000299752, OTTHUMP00000174814, ENST00000299752, OTTHUMT00000268839
    Conserved Domains (1) summary
    cd11304
    Location:342445
    Cadherin_repeat; Cadherin tandem repeat domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38 Primary Assembly

    Range
    66908122..66918984
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005255770.2XP_005255827.1  

    Conserved Domains (1) summary
    cd11304
    Location:164267
    Cadherin_repeat; Cadherin tandem repeat domain
  2. XM_005255769.2XP_005255826.1  

    Conserved Domains (1) summary
    cd11304
    Location:342445
    Cadherin_repeat; Cadherin tandem repeat domain
  3. XM_005255768.2XP_005255825.1  

    See proteins identical to XP_005255825.1

    UniProtKB/Swiss-Prot
    O75309
    Conserved Domains (1) summary
    cd11304
    Location:342445
    Cadherin_repeat; Cadherin tandem repeat domain

Alternate CHM1_1.1

Genomic

  1. NC_018927.2 Alternate CHM1_1.1

    Range
    68349034..68359895
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000148.1 Alternate HuRef

    Range
    52816134..52826996
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)