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    MELK maternal embryonic leucine zipper kinase [ Homo sapiens (human) ]

    Gene ID: 9833, updated on 19-Jul-2016
    Official Symbol
    MELKprovided by HGNC
    Official Full Name
    maternal embryonic leucine zipper kinaseprovided by HGNC
    Primary source
    HGNC:HGNC:16870
    See related
    Ensembl:ENSG00000165304 HPRD:06119; MIM:607025; Vega:OTTHUMG00000019906
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HPK38
    Orthologs
    Location:
    9p13.2
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 9 NC_000009.12 (36572862..36677683)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (36572859..36677680)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102724322 Neighboring gene high mobility group box 3 pseudogene 24 Neighboring gene ring finger protein 38 Neighboring gene mitochondrial ribosomal protein S21 pseudogene 4 Neighboring gene uncharacterized LOC105376030 Neighboring gene microRNA 4475 Neighboring gene paired box 5 Neighboring gene microRNA 4540

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat-peptide(48-60) inhibits AGC-family kinases (PKB, SGK1, S6K1, MSK1), CAMK-family kinases (CAMK1 and MELK) and a STE family kinase (MKK1) PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • KIAA0175

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    calcium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    non-membrane spanning protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    G2/M transition of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    PubMed 
    apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    hemopoiesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    intrinsic apoptotic signaling pathway in response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
     
    neural precursor cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    peptidyl-tyrosine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cell cortex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    maternal embryonic leucine zipper kinase
    Names
    pEg3 kinase
    protein kinase Eg3
    protein kinase PK38
    tyrosine-protein kinase MELK
    NP_001243614.1
    NP_001243616.1
    NP_001243617.1
    NP_001243618.1
    NP_001243619.1
    NP_001243620.1
    NP_001243621.1
    NP_001243622.1
    NP_055606.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001256685.1NP_001243614.1  maternal embryonic leucine zipper kinase isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 3' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AI590871, AK299164, BC014039, BP365611, DB368226
      Consensus CDS
      CCDS59123.1
      UniProtKB/Swiss-Prot
      Q14680
      Related
      ENSP00000437804, ENST00000541717
      Conserved Domains (4) summary
      cd12198
      Location:514608
      MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase
      smart00220
      Location:11263
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14341
      Location:281332
      UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins
      cd14078
      Location:7263
      STKc_MELK; Catalytic domain of the Serine/Threonine Kinase, Maternal Embryonic Leucine zipper Kinase
    2. NM_001256687.1NP_001243616.1  maternal embryonic leucine zipper kinase isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an exon in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AI590871, AK300761, BC014039, BP365611, DB368226
      Consensus CDS
      CCDS59124.1
      UniProtKB/Swiss-Prot
      Q14680
      Related
      ENSP00000439792, ENST00000536860
      Conserved Domains (4) summary
      cd12198
      Location:507601
      MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase
      smart00220
      Location:11215
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14341
      Location:233284
      UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins
      cl21453
      Location:7215
      PKc_like; Protein Kinases, catalytic domain
    3. NM_001256688.1NP_001243617.1  maternal embryonic leucine zipper kinase isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks two consecutive exons in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
      Source sequence(s)
      AI590871, AK293284, BC014039, BP365611, DB368226
      Consensus CDS
      CCDS59125.1
      UniProtKB/Swiss-Prot
      Q14680
      Related
      ENSP00000445452, OTTHUMP00000278708, ENST00000545008, OTTHUMT00000482751
      Conserved Domains (4) summary
      cd12198
      Location:484578
      MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase
      smart00220
      Location:11192
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14341
      Location:210261
      UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins
      cl21453
      Location:7192
      PKc_like; Protein Kinases, catalytic domain
    4. NM_001256689.1NP_001243618.1  maternal embryonic leucine zipper kinase isoform 5

      See identical proteins and their annotated locations for NP_001243618.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) initiates translation at an alternate start codon and lacks an exon in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (5) is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AB183427, AI590871, BP365611, DB368226
      Consensus CDS
      CCDS59126.1
      UniProtKB/Swiss-Prot
      Q14680
      Related
      ENSP00000441596, ENST00000543751
      Conserved Domains (4) summary
      cd12198
      Location:523617
      MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase
      smart00220
      Location:17231
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14341
      Location:249300
      UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins
      cl21453
      Location:7231
      PKc_like; Protein Kinases, catalytic domain
    5. NM_001256690.1NP_001243619.1  maternal embryonic leucine zipper kinase isoform 6

      See identical proteins and their annotated locations for NP_001243619.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) initiates translation at an alternate start codon and lacks two consecutive exons in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (6) is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AB183428, AI590871, BP365611, DB368226
      Consensus CDS
      CCDS59127.1
      UniProtKB/Swiss-Prot
      Q14680
      Related
      ENSP00000443550, ENST00000536329
      Conserved Domains (4) summary
      cd12198
      Location:484578
      MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase
      smart00220
      Location:9192
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14341
      Location:210261
      UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins
      cl21453
      Location:10192
      PKc_like; Protein Kinases, catalytic domain
    6. NM_001256691.1NP_001243620.1  maternal embryonic leucine zipper kinase isoform 7

      See identical proteins and their annotated locations for NP_001243620.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) initiates translation at an alternate start codon and lacks two exons in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (7) is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AI590871, AK293423, BP365611, DB368226, W01871
      UniProtKB/TrEMBL
      B7Z1G6
      Conserved Domains (4) summary
      cd12198
      Location:475569
      MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase
      smart00220
      Location:17183
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14341
      Location:201252
      UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins
      cl21453
      Location:7183
      PKc_like; Protein Kinases, catalytic domain
    7. NM_001256692.1NP_001243621.1  maternal embryonic leucine zipper kinase isoform 8

      See identical proteins and their annotated locations for NP_001243621.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) lacks three exons in the 5' coding region and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (8) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AI590871, AK302374, BP365611, DB368226
      Consensus CDS
      CCDS59128.1
      UniProtKB/Swiss-Prot
      Q14680
      Related
      ENSP00000439184, OTTHUMP00000278707, ENST00000536987, OTTHUMT00000482750
      Conserved Domains (4) summary
      cd12198
      Location:424518
      MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase
      smart00220
      Location:5132
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14341
      Location:150201
      UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins
      cl21453
      Location:5132
      PKc_like; Protein Kinases, catalytic domain
    8. NM_001256693.1NP_001243622.1  maternal embryonic leucine zipper kinase isoform 9

      See identical proteins and their annotated locations for NP_001243622.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) lacks two consecutive exons in the 5' region and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (9) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AI590871, AK301131, BP365611, DB368226, W01871
      UniProtKB/Swiss-Prot
      Q14680
      Conserved Domains (3) summary
      cd12198
      Location:361455
      MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase
      cd14341
      Location:87138
      UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins
      cl21453
      Location:169
      PKc_like; Protein Kinases, catalytic domain
    9. NM_014791.3NP_055606.1  maternal embryonic leucine zipper kinase isoform 1

      See identical proteins and their annotated locations for NP_055606.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AI590871, BP365611, D79997, DB368226
      Consensus CDS
      CCDS6606.1
      UniProtKB/Swiss-Prot
      Q14680
      Related
      ENSP00000298048, OTTHUMP00000021377, ENST00000298048, OTTHUMT00000052428
      Conserved Domains (4) summary
      cd12198
      Location:555649
      MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase
      smart00220
      Location:11263
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14341
      Location:281332
      UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins
      cd14078
      Location:7263
      STKc_MELK; Catalytic domain of the Serine/Threonine Kinase, Maternal Embryonic Leucine zipper Kinase

    RNA

    1. NR_046337.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10) lacks an internal exon and contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AI590871, AK296820, BC014039, BP365611, DB368226
      Related
      ENST00000627766, OTTHUMT00000482749

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p7 Primary Assembly

      Range
      36572862..36677683
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011518077.1XP_011516379.1  

      See identical proteins and their annotated locations for XP_011516379.1

      UniProtKB/Swiss-Prot
      Q14680
      Conserved Domains (4) summary
      cd12198
      Location:555649
      MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase
      smart00220
      Location:11263
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14341
      Location:281332
      UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins
      cd14078
      Location:7263
      STKc_MELK; Catalytic domain of the Serine/Threonine Kinase, Maternal Embryonic Leucine zipper Kinase
    2. XM_011518078.2XP_011516380.1  

      See identical proteins and their annotated locations for XP_011516380.1

      UniProtKB/Swiss-Prot
      Q14680
      Conserved Domains (4) summary
      cd12198
      Location:555649
      MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase
      smart00220
      Location:11263
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14341
      Location:281332
      UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins
      cd14078
      Location:7263
      STKc_MELK; Catalytic domain of the Serine/Threonine Kinase, Maternal Embryonic Leucine zipper Kinase
    3. XM_011518083.2XP_011516385.1  

      See identical proteins and their annotated locations for XP_011516385.1

      UniProtKB/Swiss-Prot
      Q14680
      Conserved Domains (4) summary
      cd12198
      Location:523617
      MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase
      smart00220
      Location:17231
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14341
      Location:249300
      UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins
      cl21453
      Location:7231
      PKc_like; Protein Kinases, catalytic domain
    4. XM_011518076.2XP_011516378.1  

      See identical proteins and their annotated locations for XP_011516378.1

      UniProtKB/Swiss-Prot
      Q14680
      Conserved Domains (4) summary
      cd12198
      Location:555649
      MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase
      smart00220
      Location:11263
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14341
      Location:281332
      UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins
      cd14078
      Location:7263
      STKc_MELK; Catalytic domain of the Serine/Threonine Kinase, Maternal Embryonic Leucine zipper Kinase
    5. XM_011518082.2XP_011516384.1  

      See identical proteins and their annotated locations for XP_011516384.1

      UniProtKB/Swiss-Prot
      Q14680
      Conserved Domains (4) summary
      cd12198
      Location:523617
      MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase
      smart00220
      Location:17231
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14341
      Location:249300
      UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins
      cl21453
      Location:7231
      PKc_like; Protein Kinases, catalytic domain
    6. XM_011518081.2XP_011516383.1  

      See identical proteins and their annotated locations for XP_011516383.1

      UniProtKB/Swiss-Prot
      Q14680
      Conserved Domains (4) summary
      cd12198
      Location:523617
      MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase
      smart00220
      Location:17231
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14341
      Location:249300
      UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins
      cl21453
      Location:7231
      PKc_like; Protein Kinases, catalytic domain
    7. XM_011518080.1XP_011516382.1  

      Conserved Domains (3) summary
      cd12198
      Location:526620
      MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase
      smart00220
      Location:11263
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14078
      Location:7263
      STKc_MELK; Catalytic domain of the Serine/Threonine Kinase, Maternal Embryonic Leucine zipper Kinase
    8. XM_011518086.2XP_011516388.1  

      Conserved Domains (3) summary
      smart00220
      Location:11263
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14341
      Location:281332
      UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins
      cd14078
      Location:7263
      STKc_MELK; Catalytic domain of the Serine/Threonine Kinase, Maternal Embryonic Leucine zipper Kinase
    9. XM_011518085.1XP_011516387.1  

      Conserved Domains (4) summary
      cd12198
      Location:472566
      MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase
      smart00220
      Location:1180
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14341
      Location:198249
      UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins
      cl21453
      Location:1180
      PKc_like; Protein Kinases, catalytic domain
    10. XM_011518079.1XP_011516381.1  

      See identical proteins and their annotated locations for XP_011516381.1

      UniProtKB/Swiss-Prot
      Q14680
      Conserved Domains (4) summary
      cd12198
      Location:555649
      MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase
      smart00220
      Location:11263
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14341
      Location:281332
      UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins
      cd14078
      Location:7263
      STKc_MELK; Catalytic domain of the Serine/Threonine Kinase, Maternal Embryonic Leucine zipper Kinase
    11. XM_011518084.2XP_011516386.1  

      See identical proteins and their annotated locations for XP_011516386.1

      UniProtKB/Swiss-Prot
      Q14680
      Conserved Domains (4) summary
      cd12198
      Location:523617
      MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase
      smart00220
      Location:17231
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14341
      Location:249300
      UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins
      cl21453
      Location:7231
      PKc_like; Protein Kinases, catalytic domain

    Alternate CHM1_1.1

    Genomic

    1. NC_018920.2 Alternate CHM1_1.1

      Range
      36573419..36678272
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)