Display Settings:

Format

Send to:

Choose Destination

Ptgs2 prostaglandin-endoperoxide synthase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29527, updated on 14-Dec-2014
Official Symbol
Ptgs2provided by RGD
Official Full Name
prostaglandin-endoperoxide synthase 2provided by RGD
Primary source
RGD:620349
See related
Ensembl:ENSRNOG00000002525
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
Cox2; COX-2
Summary
catalyzes the conversion of arachidonic acid products to prostaglandin; may play a role in response to endotoxic shock; may a role in long term potentiation [RGD, Feb 2006]
See Ptgs2 in MapViewer
Location:
13q21
Exon count:
10
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (67351230..67356920)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 13 NC_005112.3 (72315959..72324483)

Chromosome 13 - NC_005112.4Genomic Context describing neighboring genes Neighboring gene phospholipase A2, group IVA (cytosolic, calcium-dependent) Neighboring gene uncharacterized LOC100911717 Neighboring gene hypothetical LOC100364450 Neighboring gene phosducin

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enzyme binding IEA
Inferred from Electronic Annotation
more info
 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
heme binding ISO
Inferred from Sequence Orthology
more info
 
heme binding ISS
Inferred from Sequence or Structural Similarity
more info
 
lipid binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IDA
Inferred from Direct Assay
more info
PubMed 
peroxidase activity IEA
Inferred from Electronic Annotation
more info
 
prostaglandin-endoperoxide synthase activity ISO
Inferred from Sequence Orthology
more info
 
prostaglandin-endoperoxide synthase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
bone mineralization IMP
Inferred from Mutant Phenotype
more info
PubMed 
brown fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
brown fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
cellular response to ATP IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to UV IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
cellular response to mechanical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
cyclooxygenase pathway ISO
Inferred from Sequence Orthology
more info
 
cyclooxygenase pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
decidualization IMP
Inferred from Mutant Phenotype
more info
PubMed 
decidualization ISO
Inferred from Sequence Orthology
more info
 
embryo implantation IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryo implantation ISO
Inferred from Sequence Orthology
more info
 
hair cycle IEP
Inferred from Expression Pattern
more info
PubMed 
inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
maintenance of blood-brain barrier IMP
Inferred from Mutant Phenotype
more info
PubMed 
memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of calcium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell cycle IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of smooth muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of synaptic transmission, dopaminergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
ovulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of NF-kappaB import into nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of brown fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of brown fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell migration involved in sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of fever generation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of fever generation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of fibroblast growth factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of nitric oxide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of platelet-derived growth factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of smooth muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of synaptic transmission, glutamatergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transforming growth factor beta production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of vasoconstriction IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation vascular endothelial growth factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
prostaglandin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
prostaglandin biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
 
regulation of blood pressure ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
response to cytokine IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to drug IEP
Inferred from Expression Pattern
more info
PubMed 
response to estradiol IEP
Inferred from Expression Pattern
more info
PubMed 
response to fatty acid IEP
Inferred from Expression Pattern
more info
PubMed 
response to fructose IEP
Inferred from Expression Pattern
more info
PubMed 
response to glucocorticoid IEP
Inferred from Expression Pattern
more info
PubMed 
response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to lithium ion IEP
Inferred from Expression Pattern
more info
PubMed 
response to manganese ion IEP
Inferred from Expression Pattern
more info
PubMed 
response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
response to organic substance IEP
Inferred from Expression Pattern
more info
PubMed 
response to organonitrogen compound IEP
Inferred from Expression Pattern
more info
PubMed 
response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 
response to radiation IEP
Inferred from Expression Pattern
more info
PubMed 
response to tumor necrosis factor IEP
Inferred from Expression Pattern
more info
PubMed 
response to vitamin D IEP
Inferred from Expression Pattern
more info
PubMed 
sensory perception of pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Colocalizes_with caveola IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
neuron projection IEA
Inferred from Electronic Annotation
more info
 
neuron projection ISO
Inferred from Sequence Orthology
more info
 
NOT nucleus ISO
Inferred from Sequence Orthology
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
protein complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
prostaglandin G/H synthase 2
Names
prostaglandin G/H synthase 2
PGHS-2
PHS II
PGH synthase 2
cyclooxygenase 2
cyclooxygenase-2
prostaglandin H2 synthase 2
NP_058928.3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017232.3NP_058928.3  prostaglandin G/H synthase 2 precursor

    See proteins identical to NP_058928.3

    Status: PROVISIONAL

    Source sequence(s)
    U04300
    UniProtKB/Swiss-Prot
    P35355
    Related
    ENSRNOP00000003567, ENSRNOT00000003567
    Conserved Domains (3) summary
    cd09816
    Location:75562
    prostaglandin_endoperoxide_synthase; Animal prostaglandin endoperoxide synthase and related bacterial proteins
    cd00054
    Location:1955
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam03098
    Location:122568
    An_peroxidase; Animal haem peroxidase

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005112.4 

    Range
    67351230..67356920
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000081.1 

    Range
    62129439..62135131
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)