Display Settings:

Format

Send to:

Choose Destination

MKI67 marker of proliferation Ki-67 [ Homo sapiens (human) ]

Gene ID: 4288, updated on 15-Sep-2014
Official Symbol
MKI67provided by HGNC
Official Full Name
marker of proliferation Ki-67provided by HGNC
Primary source
HGNC:HGNC:7107
Locus tag
RP11-380J17.2
See related
Ensembl:ENSG00000148773; HPRD:08902; MIM:176741; Vega:OTTHUMG00000019255
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KIA; MIB-; MIB-1; PPP1R105
Summary
This gene encodes a nuclear protein that is associated with and may be necessary for cellular proliferation. Alternatively spliced transcript variants have been described. A related pseudogene exists on chromosome X. [provided by RefSeq, Mar 2009]
See MKI67 in Epigenomics, MapViewer
Location:
10q26.2
Exon count:
16
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 10 NC_000010.11 (128096659..128126204, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (129894923..129924468, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene clarin 3 Neighboring gene protein tyrosine phosphatase, receptor type, E Neighboring gene long intergenic non-protein coding RNA 1163 Neighboring gene O-6-methylguanine-DNA methyltransferase

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association with select biomarker traits in the Framingham Heart Study.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Nef nef Podocyte-specific expression of HIV-1 Nef induces loss of synaptopodin and WT1, and expression of Ki-67 in podocytes, which is essential for the dedifferentiation and proliferation of podocytes in HIV-associated nephropathy PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
poly(A) RNA binding IDA
Inferred from Direct Assay
more info
 
protein C-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA metabolic process IEA
Inferred from Electronic Annotation
more info
 
cell proliferation TAS
Traceable Author Statement
more info
PubMed 
cellular response to heat IEA
Inferred from Electronic Annotation
more info
 
hyaluronan metabolic process IEA
Inferred from Electronic Annotation
more info
 
meiotic nuclear division IEA
Inferred from Electronic Annotation
more info
 
organ regeneration IEA
Inferred from Electronic Annotation
more info
 
response to organic cyclic compound IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
 
condensed chromosome IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
Preferred Names
antigen KI-67
Names
antigen KI-67
proliferation-related Ki-67 antigen
protein phosphatase 1, regulatory subunit 105
antigen identified by monoclonal antibody Ki-67

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145966.1NP_001139438.1  antigen KI-67 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AL355529, AL390236, BU632619, BU855841, X65551
    Consensus CDS
    CCDS53588.1
    UniProtKB/Swiss-Prot
    P46013
    Related
    ENSP00000357642, OTTHUMP00000020740, ENST00000368653, OTTHUMT00000051000
    Conserved Domains (4) summary
    pfam08065
    Location:764875
    K167R; K167R (NUC007) repeat
    COG1716
    Location:11119
    COG1716; FOG: FHA domain [Signal transduction mechanisms]
    cd00060
    Location:898
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam15276
    Location:142203
    PP1_bind; Protein phosphatase 1 binding
  2. NM_002417.4NP_002408.3  antigen KI-67 isoform 1

    See proteins identical to NP_002408.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL355529, AL390236, BU632619, BU855841, X65550
    Consensus CDS
    CCDS7659.1
    UniProtKB/Swiss-Prot
    P46013
    Related
    ENSP00000357643, OTTHUMP00000020739, ENST00000368654, OTTHUMT00000050999
    Conserved Domains (4) summary
    pfam08065
    Location:11241235
    K167R; K167R (NUC007) repeat
    COG1716
    Location:11119
    COG1716; FOG: FHA domain [Signal transduction mechanisms]
    cd00060
    Location:898
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam15276
    Location:502563
    PP1_bind; Protein phosphatase 1 binding

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000010.11 

    Range
    128096659..128126204
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006717864.1XP_006717927.1  

    Conserved Domains (1) summary
    pfam08065
    Location:274385
    K167R; K167R (NUC007) repeat

Alternate HuRef

Genomic

  1. AC_000142.1 

    Range
    123469633..123499187
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018921.2 

    Range
    130177330..130206878
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)