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Slc12a2 solute carrier family 12, member 2 [ Mus musculus (house mouse) ]

Gene ID: 20496, updated on 9-May-2015
Official Symbol
Slc12a2provided by MGI
Official Full Name
solute carrier family 12, member 2provided by MGI
Primary source
MGI:MGI:101924
See related
Ensembl:ENSMUSG00000024597
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nkcc1; mBSC2; sy-ns; 9330166H04Rik
Orthologs
See Slc12a2 in MapViewer
Location:
18 D3; 18 32.15 cM
Exon count:
28
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 18 NC_000084.6 (57878513..57946821)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (58038332..58106475)

Chromosome 18 - NC_000084.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 19519 Neighboring gene predicted gene, 35751 Neighboring gene fibrillin 2 Neighboring gene predicted gene, 41741

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ammonium transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
cation:chloride symporter activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sodium:potassium:chloride symporter activity ISO
Inferred from Sequence Orthology
more info
 
symporter activity IEA
Inferred from Electronic Annotation
more info
 
transporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
ammonium transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
ammonium transport ISO
Inferred from Sequence Orthology
more info
 
branching involved in mammary gland duct morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
chloride transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
chloride transport ISO
Inferred from Sequence Orthology
more info
 
detection of mechanical stimulus involved in sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
PubMed 
hyperosmotic response ISO
Inferred from Sequence Orthology
more info
 
ion transport IEA
Inferred from Electronic Annotation
more info
 
mammary duct terminal end bud growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
organic cation transport ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell volume ISO
Inferred from Sequence Orthology
more info
 
potassium ion transport ISO
Inferred from Sequence Orthology
more info
 
sodium ion transport ISO
Inferred from Sequence Orthology
more info
 
transepithelial ammonium transport ISO
Inferred from Sequence Orthology
more info
 
transepithelial chloride transport ISO
Inferred from Sequence Orthology
more info
 
transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
extracellular vesicle ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
solute carrier family 12 member 2
Names
solute carrier family 12 member 2
basolateral Na-K-Cl symporter
bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1
sodium/potassium/chloride cotransporters
sodium/potassium/chloride transporters

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009194.3NP_033220.2  solute carrier family 12 member 2

    Status: VALIDATED

    Source sequence(s)
    AC127678, CJ172807, CN711123, U13174
    Consensus CDS
    CCDS37826.1
    UniProtKB/TrEMBL
    E9QM38
    UniProtKB/Swiss-Prot
    P55012
    Related
    ENSMUSP00000111023, ENSMUST00000115366
    Conserved Domains (2) summary
    TIGR00930
    Location:2101206
    2a30; K-Cl cotransporter
    pfam08403
    Location:195261
    AA_permease_N; Amino acid permease N-terminal

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000084.6 Reference GRCm38.p3 C57BL/6J

    Range
    57878513..57946821
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006525732.1XP_006525795.1  

    Conserved Domains (2) summary
    TIGR00930
    Location:2101190
    2a30; K-Cl cotransporter
    pfam08403
    Location:195261
    AA_permease_N; Amino acid permease N-terminal

RNA

  1. XR_385981.1 RNA Sequence

Alternate Mm_Celera

Genomic

  1. AC_000040.1 Alternate Mm_Celera

    Range
    59157060..59258313
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)