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    TP53 tumor protein p53 [ Homo sapiens (human) ]

    Gene ID: 7157, updated on 30-Jun-2015
    Official Symbol
    TP53provided by HGNC
    Official Full Name
    tumor protein p53provided by HGNC
    Primary source
    HGNC:HGNC:11998
    See related
    Ensembl:ENSG00000141510; HPRD:01859; MIM:191170; Vega:OTTHUMG00000162125
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    P53; BCC7; LFS1; TRP53
    Summary
    This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277). [provided by RefSeq, Feb 2013]
    Orthologs
    See TP53 in Epigenomics, MapViewer
    Location:
    17p13.1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 17 NC_000017.11 (7668402..7687550, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (7571720..7590868, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene sex hormone-binding globulin Neighboring gene spermidine/spermine N1-acetyltransferase family member 2 Neighboring gene ATPase, Na+/K+ transporting, beta 2 polypeptide Neighboring gene WD repeat containing, antisense to TP53 Neighboring gene ephrin-B3 Neighboring gene dynein, axonemal, heavy chain 2 Neighboring gene ribosomal protein L29 pseudogene 2

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Professional guidelines

    Description
    Professional guideline
    ACMG 2013

    The ACMG recommends that laboratories performing clinical sequencing seek and report mutations in TP53 that are pathogenic or expected to be pathogenic.

    GuidelinePubMed

    Associated conditions

    Description Tests
    Adrenocortical carcinoma, hereditary
    MedGen: C1859972 OMIM: 202300 GeneReviews: Not available
    Compare labs
    Basal cell carcinoma, susceptibility to, 7
    MedGen: C3553606 OMIM: 614740 GeneReviews: Not available
    Compare labs
    Carcinoma of colon
    MedGen: C0699790 OMIM: 114500 GeneReviews: Not available
    Compare labs
    Carcinoma of pancreas
    MedGen: C0235974 OMIM: 260350 GeneReviews: Not available
    Compare labs
    Choroid plexus papilloma
    MedGen: C0205770 OMIM: 260500 GeneReviews: Not available
    Compare labs
    Familial cancer of breast not available
    Glioma susceptibility 1
    MedGen: C2750850 OMIM: 137800 GeneReviews: Not available
    Compare labs
    Hepatocellular carcinoma
    MedGen: C2239176 OMIM: 114550 GeneReviews: Not available
    Compare labs
    Li-Fraumeni syndrome 1
    MedGen: C1835398 OMIM: 151623 GeneReviews: Li-Fraumeni Syndrome
    Compare labs
    Nasopharyngeal carcinoma
    MedGen: C2931822 OMIM: 607107 GeneReviews: Not available
    Compare labs
    Osteosarcoma
    MedGen: C0029463 OMIM: 259500 GeneReviews: Not available
    Compare labs

    Copy number response

    Description
    Copy number response
    Triplosensitivity

    No evidence available (Last evaluated (2012-09-20)

    ClinGen Genome Curation Page
    Haploinsufficency

    Sufficient evidence for dosage pathogenicity (Last evaluated (2012-09-20)

    ClinGen Genome Curation PagePubMed

    NHGRI GWAS Catalog

    Description
    A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation.
    NHGRI GWA Catalog
    A germline variant in the TP53 polyadenylation signal confers cancer susceptibility.
    NHGRI GWA Catalog
    Germline sequence variants in TGM3 and RGS22 confer risk of basal cell carcinoma.
    NHGRI GWA Catalog
    Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 is potentially cytotoxic to human cells through the induction of p53, which may eventually lead to induction of apoptosis PubMed
    env Caspase 8 proteolytic target protein Bid is cleaved and undergoes mitochondrial translocation in gp120-treated p53 expression neurons PubMed
    env HIV-1 gp120-mediated activation of caspase 8 occurs in a p53 independent manner, while HIV-1 gp120-mediated activation of caspase 3 requires p53 PubMed
    env Tumor suppressor protein PML is required for the activating phosphorylation of ATM, p38 MAPK, and p53 in HIV-1 Env-elicited syncytia PubMed
    env p38 MAPK-mediated p53 phosphorylation on serine 46 contributes to apoptosis induced by the HIV-1 envelope glycoprotein complex (gp120/gp41) PubMed
    env Syncytial apoptosis mediated by the fusion of cells expressing HIV-1 gp120 with cells expressing the CD4/CXCR4 receptor/coreceptor complex causes phosphorylation of p53 on serine 15 and Bax upregulation PubMed
    Nef nef Assays with phage-displayed Nef from HIV-1 NL4-3 have been used to identify a series of guanidine alkaloid-based inhibitors of Nef interactions with p53, actin, and p56(lck) PubMed
    nef HIV-1 Nef binds directly to tumor suppressor protein p53; an N-terminal 57-residue fragment of Nef (Nef 1-57) contains the p53-binding domain PubMed
    Rev rev HIV-1 Tat reactivates latent HIV-1 proviruses in J1.1 and ACH-2 cell lines and promotes p53-induced apoptosis in the presence of Rev PubMed
    Tat tat Treatment with HIV-Tat and morphine activates extracellular signal-regulated kinase-1/2 (ERK1/2), upregulates p53 and p21 levels, and downregulates cyclin D1 and Akt levels in human fetal brain-derived neural precursor cells PubMed
    tat HIV-1 Tat activates the p53 transcription factor pathway leading to the induction of endogenous p53 and p73 in neuronal cells PubMed
    tat HIV-1 Tat inhibits SIRT1 and increases acetylation of p53, which leads to activation of p21 and BAX in HeLa-CD4+ cells PubMed
    tat When expressed in astrocytes, neurons, and non-glial 293T cells, HIV-1 Tat interacts with a number of cell cycle-related proteins including cyclin A, cyclin B, cyclin D3, Cdk2, Cdk4, Cdk1/Cdc2, cdc6, p27, p53, p63, hdlg, and PCNA PubMed
    tat HIV-1 Tat reactivates latent HIV-1 proviruses in J1.1 and ACH-2 cell lines and promotes p53-induced apoptosis in the presence of Rev PubMed
    tat The p53 tetramerization domain (residues 326-355) binds directly to residues 1-35 and 47-57 in HIV-1 Tat as evidenced by using peptide mapping, fluorescence anisotropy, and NMR spectroscopy PubMed
    tat In the absence of either p53 or p73, Tat fails to induce dendritic retraction or to activate the proapoptotic proteins, such as Bax PubMed
    tat Activation of p38 MAPK in HIV-infected cells mediated by Tat leads to the phosphorylation of p53 which subsequently upregulates CAV-1 expression PubMed
    tat Wild-type p53 is a potent inhibitor of HIV-1 Tat transactivation of the HIV-1 LTR promoter in Jurkat T cells and Hep3B cells PubMed
    tat HIV-1 Tat downregulates the expression of p53, suggesting a mechanism for HIV-1-mediated transformation of infected cells PubMed
    tat HIV-1 Tat binds to p53, an interaction mediated by the basic region of Tat (amino acids 49-57) and the acidic O2 domain of p53 (amino acids 341-354 PubMed
    tat Supernatants from HIV-1 Tat-transfected monocytoid cells induces p53 expression in neurons, indicating a role for Tat in the neuropathogenesis of HIV-1 PubMed
    tat HIV-1 Tat inhibits p53-responsive transcription by binding to histone acetyltransferases and repressing the acetylation of p53 on residue Lys-320, alluding to a mechanism whereby Tat may impair p53 functions, thus favoring the establishment of neoplasia PubMed
    tat HIV-1 Tat and p53 cooperate in the activation of HIV-1 gene expression in SaOS2 cells PubMed
    Vif vif HIV-1 Vif stabilizes TP53 by blocking MDM2-induced ubiquitination and inhibits MDM2-mediated nuclear export of TP53, leading to support viral replication through inducing G2 cell cycle arrest PubMed
    vif The N-terminal region (residues 1-50) of HIV-1 Vif is important for binding to TP53 PubMed
    Vpr vpr HIV-1 Vpr interacts with p53 in a complex with the transcription factor Sp1 that modulates viral gene transcription from the HIV-1 LTR promoter PubMed
    vpr HIV-1 Vpr downregulates proliferation-associated protein 2G4 (PA2G4) and upregulates p53 in glioblastoma U87MG cells PubMed
    vpr Exposure of cultured human primary astrocytes to HIV-1 Vpr induces p53 up-regulation, loss of mitochondrial membrane potential, and caspase-6 activation followed by cell injury PubMed
    vpr Soluble HIV-1 Vpr causes neuronal apoptosis, involving cytochrome c extravasation, p53 induction, and activation of caspase-9 PubMed
    vpr HIV-1 Vpr inhibits the interaction of p53 and Rad51 in chromatin fractions, as observed under irradiation-induced DNA double-strand breaks PubMed
    vpr Results from GST pull-down assays show the association of Vpr with p53 in extracts containing Sp1, suggesting the physical interaction of Vpr with Sp1 and p53 could modulate transcriptional activity of p21 PubMed
    vpr Activation of p21/Waf1/Cip1 by HIV-1 Vpr appears to be regulated by p53 PubMed
    vpr HIV-1 Vpr can neutralize inhibitory effects of the human homologue of yeast Rad23 protein A (hHR23A) on p53, thereby activating p53 transcriptional activity PubMed
    vpr Overexpression of p53 decreases the level of activation of the viral LTR promoter by HIV-1 Vpr PubMed
    Vpu vpu HIV-1 Vpu expression results in significant upregulation of phosphorylated p53. Vpu contributes to p53-dependent apoptosis in HIV-1-infected cells PubMed
    vpu HIV-1 Vpu expression leads to stabilization and upregulation of p53 via inhibiting association of p53 with beta-TrCP and its subsequent ubiquitination PubMed
    integrase gag-pol HIV-1 IN-mediated proviral DNA integration triggers cell death during HIV-1 infection. The mechanism of killing during viral integration involves activation of DNA-PK, which causes phosphorylation of p53 and histone gammaH2AX PubMed
    reverse transcriptase gag-pol Tumor suppressor protein p53 displays 3' --> 5' exonuclease activity, and interaction of p53 with HIV-1 reverse transcriptase (RT) can provide a proofreading function for HIV-1 RT PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Clone Names

    • FLJ92943

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA
    Inferred from Electronic Annotation
    more info
     
    RNA polymerase II core promoter sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA polymerase II transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chaperone binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    copper ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    core promoter sequence-specific DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    damaged DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    double-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    histone acetyltransferase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    histone deacetylase regulator activity IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    p53 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protease binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein N-terminus binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein phosphatase 2A binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein self-association IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    receptor tyrosine kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    sequence-specific DNA binding RNA polymerase II transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sequence-specific DNA binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription regulatory region DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    zinc ion binding TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    B cell lineage commitment IEA
    Inferred from Electronic Annotation
    more info
     
    DNA damage response, signal transduction by p53 class mediator IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA damage response, signal transduction by p53 class mediator IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS
    Traceable Author Statement
    more info
     
    DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    DNA strand renaturation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ER overload response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Notch signaling pathway TAS
    Traceable Author Statement
    more info
     
    Ras protein signal transduction IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    T cell differentiation in thymus IEA
    Inferred from Electronic Annotation
    more info
     
    T cell lineage commitment IEA
    Inferred from Electronic Annotation
    more info
     
    T cell proliferation involved in immune response IEA
    Inferred from Electronic Annotation
    more info
     
    apoptotic process TAS
    Traceable Author Statement
    more info
     
    base-excision repair TAS
    Traceable Author Statement
    more info
    PubMed 
    blood coagulation TAS
    Traceable Author Statement
    more info
     
    cell aging IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell cycle arrest IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell cycle arrest IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell differentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    cell proliferation TAS
    Traceable Author Statement
    more info
    PubMed 
    cellular protein localization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to DNA damage stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to UV IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cellular response to UV-C IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to drug IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to glucose starvation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to ionizing radiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cerebellum development IEA
    Inferred from Electronic Annotation
    more info
     
    chromatin assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    circadian behavior ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    determination of adult lifespan ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    double-strand break repair IEA
    Inferred from Electronic Annotation
    more info
     
    embryonic organ development IEA
    Inferred from Electronic Annotation
    more info
     
    entrainment of circadian clock by photoperiod ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    gastrulation IEA
    Inferred from Electronic Annotation
    more info
     
    gene expression TAS
    Traceable Author Statement
    more info
     
    in utero embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    intrinsic apoptotic signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    intrinsic apoptotic signaling pathway by p53 class mediator IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intrinsic apoptotic signaling pathway in response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    mitotic G1 DNA damage checkpoint IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitotic cell cycle arrest IEA
    Inferred from Electronic Annotation
    more info
     
    multicellular organism growth IEA
    Inferred from Electronic Annotation
    more info
     
    multicellular organismal development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    necroptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of DNA replication IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of fibroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of glucose catabolic process to lactate via pyruvate IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of helicase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of macromitophagy IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of neuroblast proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of reactive oxygen species metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    negative regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription, DNA-templated ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    negative regulation of transforming growth factor beta receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide-excision repair IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    oligodendrocyte apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    oxidative stress-induced premature senescence IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cardiac muscle cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell cycle arrest IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of execution phase of apoptosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of histone deacetylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of mitochondrial membrane permeability IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of neuron apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of peptidyl-tyrosine phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway TAS
    Traceable Author Statement
    more info
     
    positive regulation of protein oligomerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of reactive oxygen species metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of release of cytochrome c from mitochondria IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of thymocyte apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of transcription from RNA polymerase II promoter in response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    programmed cell death TAS
    Traceable Author Statement
    more info
     
    protein complex assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein import into nucleus, translocation IEA
    Inferred from Electronic Annotation
    more info
     
    protein localization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein tetramerization TAS
    Traceable Author Statement
    more info
    PubMed 
    rRNA transcription IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of cellular senescence IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of fibroblast apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of intrinsic apoptotic signaling pathway by p53 class mediator IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of mitochondrial membrane permeability TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of mitochondrial membrane permeability involved in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of tissue remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    release of cytochrome c from mitochondria IEA
    Inferred from Electronic Annotation
    more info
     
    replicative senescence IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to X-ray IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    response to antibiotic IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to gamma radiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to ischemia IEA
    Inferred from Electronic Annotation
    more info
     
    response to salt stress IEA
    Inferred from Electronic Annotation
    more info
     
    somitogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    transcription initiation from RNA polymerase II promoter TAS
    Traceable Author Statement
    more info
     
    transforming growth factor beta receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    viral process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    PML body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with nuclear body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    replication fork IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    colocalizes_with transcription factor TFIID complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    cellular tumor antigen p53
    Names
    antigen NY-CO-13
    mutant tumor protein 53
    p53 tumor suppressor
    phosphoprotein p53
    transformation-related protein 53
    tumor protein 53

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_017013.2 RefSeqGene

      Range
      5001..24149
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_321

    mRNA and Protein(s)

    1. NM_000546.5NP_000537.3  cellular tumor antigen p53 isoform a

      See identical proteins and their annotated locations for NP_000537.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) can initiate translation from two in-frame AUG start codons. The isoform represented in this variant (a, also known as p53alpha) results from translation initiation at the upstream start codon. Both variants 1 and 2 encode isoform a, which is the longest isoform.
      Source sequence(s)
      AK223026, DA453049, DQ186650, X02469
      Consensus CDS
      CCDS11118.1
      UniProtKB/TrEMBL
      K7PPA8
      UniProtKB/Swiss-Prot
      P04637
      UniProtKB/TrEMBL
      Q53GA5
      Related
      ENSP00000269305, OTTHUMP00000221333, ENST00000269305, OTTHUMT00000367397
      Conserved Domains (3) summary
      pfam08563
      Location:529
      P53_TAD; P53 transactivation motif
      cd08367
      Location:109288
      P53; P53 DNA-binding domain
      pfam07710
      Location:324359
      P53_tetramer; P53 tetramerization motif
    2. NM_001126112.2NP_001119584.1  cellular tumor antigen p53 isoform a

      See identical proteins and their annotated locations for NP_001119584.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. This variant can initiate translation from two in-frame AUG start codons. The isoform represented in this variant (a, also known as p53alpha) results from translation initiation at the upstream start codon. Both variants 1 and 2 encode isoform a, which is the longest isoform.
      Source sequence(s)
      AB082923, AK223026, DA453049, DQ186650, X02469
      Consensus CDS
      CCDS11118.1
      UniProtKB/TrEMBL
      K7PPA8
      UniProtKB/Swiss-Prot
      P04637
      UniProtKB/TrEMBL
      Q53GA5
      Related
      ENSP00000391478, OTTHUMP00000221334, ENST00000445888, OTTHUMT00000367398
      Conserved Domains (3) summary
      pfam08563
      Location:529
      P53_TAD; P53 transactivation motif
      cd08367
      Location:109288
      P53; P53 DNA-binding domain
      pfam07710
      Location:324359
      P53_tetramer; P53 tetramerization motif
    3. NM_001126113.2NP_001119585.1  cellular tumor antigen p53 isoform c

      See identical proteins and their annotated locations for NP_001119585.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) contains an additional exon in the 3' coding region, resulting in an alternate 3' coding region and 3' UTR, compared to variant 1. This variant can initiate translation from two in-frame AUG start codons. The isoform represented in this variant (c, also known as p53gamma) results from translation initiation at the upstream start codon. It has a shorter and distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AK223026, DA453049, DQ186649, DQ186650
      Consensus CDS
      CCDS45605.1
      UniProtKB/Swiss-Prot
      P04637
      UniProtKB/TrEMBL
      Q53GA5
      Related
      ENSP00000398846, OTTHUMP00000221336, ENST00000455263, OTTHUMT00000367400
      Conserved Domains (2) summary
      pfam08563
      Location:529
      P53_TAD; P53 transactivation motif
      cd08367
      Location:109288
      P53; P53 DNA-binding domain
    4. NM_001126114.2NP_001119586.1  cellular tumor antigen p53 isoform b

      See identical proteins and their annotated locations for NP_001119586.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an additional exon in the 3' coding region, resulting in an alternate 3' coding region and 3' UTR, compared to variant 1. This variant can initiate translation from two in-frame AUG start codons. The isoform represented in this variant (b, also known as p53beta) results from translation initiation at the upstream start codon. It has a shorter and distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AK223026, DA453049, DQ186648, DQ186649, DQ186650
      Consensus CDS
      CCDS45606.1
      UniProtKB/Swiss-Prot
      P04637
      UniProtKB/TrEMBL
      Q53GA5
      Related
      ENSP00000482258, ENST00000617185
      Conserved Domains (2) summary
      pfam08563
      Location:529
      P53_TAD; P53 transactivation motif
      cd08367
      Location:109288
      P53; P53 DNA-binding domain
    5. NM_001126115.1NP_001119587.1  cellular tumor antigen p53 isoform d

      See identical proteins and their annotated locations for NP_001119587.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses an alternate promoter and lacks multiple 5' exons, compared to variant 1. This variant can initiate translation from two in-frame AUG start codons. The isoform represented in this variant (d, also known as delta133p53alpha) results from translation initiation at the upstream start codon. It has a shorter N-terminus, compared to isoform a. This variant is supported by data in PMID:16131611.
      Source sequence(s)
      AC087388, AK223026, DQ186650
      Consensus CDS
      CCDS73966.1
      UniProtKB/Swiss-Prot
      P04637
      UniProtKB/TrEMBL
      Q53GA5
      Related
      ENSP00000481179, OTTHUMP00000275600, ENST00000504937, OTTHUMT00000367404
      Conserved Domains (2) summary
      cd08367
      Location:1156
      P53; P53 DNA-binding domain
      pfam07710
      Location:192227
      P53_tetramer; P53 tetramerization motif
    6. NM_001126116.1NP_001119588.1  cellular tumor antigen p53 isoform e

      See identical proteins and their annotated locations for NP_001119588.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) uses an alternate promoter and lacks multiple 5' exons, compared to variant 1. This variant can initiate translation from two in-frame AUG start codons. The isoform represented in this variant (e, also known as delta133p53beta) results from translation initiation at the upstream start codon. It has a shorter N-terminus and a distinct C-terminus, compared to isoform a. This variant is supported by data in PMID:16131611.
      Source sequence(s)
      AC087388, AK223026, DQ186651
      Consensus CDS
      CCDS73968.1
      UniProtKB/Swiss-Prot
      P04637
      UniProtKB/TrEMBL
      Q53GA5
      Related
      ENSP00000478499, OTTHUMP00000275599, ENST00000510385, OTTHUMT00000367403
      Conserved Domains (1) summary
      cd08367
      Location:1156
      P53; P53 DNA-binding domain
    7. NM_001126117.1NP_001119589.1  cellular tumor antigen p53 isoform f

      See identical proteins and their annotated locations for NP_001119589.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) uses an alternate promoter and lacks multiple 5' exons, compared to variant 1. This variant can initiate translation from two in-frame AUG start codons. The isoform represented in this variant (f, also known as delta133p53gamma) results from translation initiation at the upstream start codon. It has a shorter N-terminus and a distinct C-terminus, compared to isoform a. This variant is supported by data in PMID:16131611.
      Source sequence(s)
      AC087388, AK223026, DQ186652
      Consensus CDS
      CCDS73967.1
      UniProtKB/Swiss-Prot
      P04637
      UniProtKB/TrEMBL
      Q53GA5
      Related
      ENSP00000484409, OTTHUMP00000275598, ENST00000504290, OTTHUMT00000367402
      Conserved Domains (1) summary
      cd08367
      Location:1156
      P53; P53 DNA-binding domain
    8. NM_001126118.1NP_001119590.1  cellular tumor antigen p53 isoform g

      See identical proteins and their annotated locations for NP_001119590.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8, also known as p53I2) differs in the 5' UTR, and uses an in-frame downstream start codon, compared to variant 1. The encoded isoform (g, also known as delta40p53alpha or deltaNp53) has a shorter N-terminus, compared to isoform a. This variant is supported by data in PMID:21112961.
      Source sequence(s)
      AK223026, DA453049, DC347346, DQ186650, DQ191317, X60016
      Consensus CDS
      CCDS73969.1
      UniProtKB/TrEMBL
      H2EHT1
      UniProtKB/Swiss-Prot
      P04637
      UniProtKB/TrEMBL
      Q53GA5
      Related
      ENSP00000478219, OTTHUMP00000275602, ENST00000610292, OTTHUMT00000476360
      Conserved Domains (2) summary
      cd08367
      Location:70249
      P53; P53 DNA-binding domain
      pfam07710
      Location:285320
      P53_tetramer; P53 tetramerization motif
    9. NM_001276695.1NP_001263624.1  cellular tumor antigen p53 isoform h

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) contains an additional exon in the 3' coding region, resulting in an alternate 3' coding region and 3' UTR, compared to variant 1. This variant can initiate translation from two in-frame AUG start codons. The isoform represented in this variant (h, also known as delta40p53gamma) results from translation initiation at the downstream start codon. It has a shorter N-terminus and a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AK223026, DA453049, DQ186649, DQ186650
      Consensus CDS
      CCDS73970.1
      UniProtKB/Swiss-Prot
      P04637
      UniProtKB/TrEMBL
      Q53GA5
      Related
      ENSP00000480868, OTTHUMP00000275851, ENST00000610538, OTTHUMT00000476703
      Conserved Domains (1) summary
      cd08367
      Location:70249
      P53; P53 DNA-binding domain
    10. NM_001276696.1NP_001263625.1  cellular tumor antigen p53 isoform i

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an additional exon in the 3' region, resulting in an alternate 3' coding region and 3' UTR, compared to variant 1. This variant can initiate translation from two in-frame AUG start codons. The isoform represented in this variant (i, also known as delta40p53beta) results from translation initiation at the downstream start codon. It has a shorter N-terminus and a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AK223026, DA453049, DQ186648, DQ186649, DQ186650
      Consensus CDS
      CCDS73971.1
      UniProtKB/Swiss-Prot
      P04637
      UniProtKB/TrEMBL
      Q53GA5
      Related
      ENSP00000482222, OTTHUMP00000275603, ENST00000622645, OTTHUMT00000476361
      Conserved Domains (1) summary
      cd08367
      Location:70249
      P53; P53 DNA-binding domain
    11. NM_001276697.1NP_001263626.1  cellular tumor antigen p53 isoform j

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses an alternate promoter and lacks multiple 5' exons, compared to variant 1. This variant can initiate translation from two in-frame AUG start codons. The isoform represented in this variant (j, also known as delta160p53alpha) results from translation initiation at the downstream start codon. It has a shorter N-terminus, compared to isoform a. This variant is supported by data in PMID:16131611.
      Source sequence(s)
      AC087388, AK223026, DQ186650
      Consensus CDS
      CCDS73963.1
      UniProtKB/TrEMBL
      A0A087X1Q1
      UniProtKB/Swiss-Prot
      P04637
      UniProtKB/TrEMBL
      Q53GA5
      Related
      ENSP00000484375, OTTHUMP00000275596, ENST00000619186, OTTHUMT00000476357
      Conserved Domains (2) summary
      cd08367
      Location:1129
      P53; P53 DNA-binding domain
      pfam07710
      Location:165200
      P53_tetramer; P53 tetramerization motif
    12. NM_001276698.1NP_001263627.1  cellular tumor antigen p53 isoform k

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) uses an alternate promoter and lacks multiple 5' exons, compared to variant 1. This variant can initiate translation from two in-frame AUG start codons. The isoform represented in this variant (k, also known as delta160p53beta) results from translation initiation at the downstream start codon. It has a shorter N-terminus and a distinct C-terminus, compared to isoform a. This variant is supported by data in PMID:16131611.
      Source sequence(s)
      AC087388, AK223026, DQ186651
      Consensus CDS
      CCDS73965.1
      UniProtKB/TrEMBL
      A0A087WXZ1
      UniProtKB/Swiss-Prot
      P04637
      UniProtKB/TrEMBL
      Q53GA5
      Related
      ENSP00000481401, OTTHUMP00000275597, ENST00000618944, OTTHUMT00000476358
      Conserved Domains (1) summary
      cd08367
      Location:1129
      P53; P53 DNA-binding domain
    13. NM_001276699.1NP_001263628.1  cellular tumor antigen p53 isoform l

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) uses an alternate promoter and lacks multiple 5' exons, compared to variant 1. This variant can initiate translation from two in-frame AUG start codons. The isoform represented in this variant (l, also known as delta160p53gamma) results from translation initiation at the downstream start codon. It has a shorter N-terminus and a distinct C-terminus, compared to isoform a. This variant is supported by data in PMID:16131611.
      Source sequence(s)
      AC087388, AK223026, DQ186652
      Consensus CDS
      CCDS73964.1
      UniProtKB/TrEMBL
      A0A087WT22
      UniProtKB/Swiss-Prot
      P04637
      UniProtKB/TrEMBL
      Q53GA5
      Related
      ENSP00000477531, OTTHUMP00000275850, ENST00000610623, OTTHUMT00000476702
      Conserved Domains (1) summary
      cd08367
      Location:1129
      P53; P53 DNA-binding domain
    14. NM_001276760.1NP_001263689.1  cellular tumor antigen p53 isoform g

      See identical proteins and their annotated locations for NP_001263689.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) can initiate translation from two in-frame AUG start codons. The isoform represented in this variant (g, also known as delta40p53alpha or deltaNp53) results from translation initiation at the downstream start codon. It has a shorter N-terminus, compared to isoform a. Variants 1, 2, and 8 encode isoform g.
      Source sequence(s)
      AK223026, DA453049, DQ186650, X02469
      Consensus CDS
      CCDS73969.1
      UniProtKB/TrEMBL
      H2EHT1
      UniProtKB/Swiss-Prot
      P04637
      UniProtKB/TrEMBL
      Q53GA5
      Related
      ENSP00000481638, OTTHUMP00000275601, ENST00000620739, OTTHUMT00000476359
      Conserved Domains (2) summary
      cd08367
      Location:70249
      P53; P53 DNA-binding domain
      pfam07710
      Location:285320
      P53_tetramer; P53 tetramerization motif
    15. NM_001276761.1NP_001263690.1  cellular tumor antigen p53 isoform g

      See identical proteins and their annotated locations for NP_001263690.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. This variant can initiate translation from two in-frame AUG start codons. The isoform represented in this variant (g, also known as delta40p53alpha or deltaNp53) results from translation initiation at the downstream start codon. It has a shorter N-terminus, compared to isoform a. Variants 1, 2, and 8 encode isoform g.
      Source sequence(s)
      AB082923, AK223026, DA453049, DQ186650, X02469
      Consensus CDS
      CCDS73969.1
      UniProtKB/TrEMBL
      H2EHT1
      UniProtKB/Swiss-Prot
      P04637
      UniProtKB/TrEMBL
      Q53GA5
      Related
      ENSP00000482537, OTTHUMP00000275852, ENST00000619485, OTTHUMT00000476704
      Conserved Domains (2) summary
      cd08367
      Location:70249
      P53; P53 DNA-binding domain
      pfam07710
      Location:285320
      P53_tetramer; P53 tetramerization motif

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p2 Primary Assembly

      Range
      7668402..7687550
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018928.2 Alternate CHM1_1.1

      Range
      7580866..7600003
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)