Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information

Aicda activation-induced cytidine deaminase [ Mus musculus (house mouse) ]

Gene ID: 11628, updated on 8-Jul-2014
Official Symbol
Aicdaprovided by MGI
Official Full Name
activation-induced cytidine deaminaseprovided by MGI
Primary source
MGI:1342279
See related
Ensembl:ENSMUSG00000040627; Vega:OTTMUSG00000034572
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Aid; Arp2
See Aicda in Epigenomics, MapViewer
Location:
6; 6 F2
Exon count :
5
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 6 NC_000072.6 (122553809..122564180)

Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene ribosomal modification protein rimK-like family member B Neighboring gene predicted pseudogene 8430 Neighboring gene microfibrillar associated protein 5 Neighboring gene voltage-dependent anion channel 1 pseudogene Neighboring gene apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
catalytic activity IEA
Inferred from Electronic Annotation
more info
 
cytidine deaminase activity IDA
Inferred from Direct Assay
more info
PubMed 
cytidine deaminase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytidine deaminase activity ISO
Inferred from Sequence Orthology
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
DNA demethylation ISO
Inferred from Sequence Orthology
more info
 
cellular response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytidine deamination IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytidine deamination ISO
Inferred from Sequence Orthology
more info
 
isotype switching IMP
Inferred from Mutant Phenotype
more info
PubMed 
mRNA processing IEA
Inferred from Electronic Annotation
more info
 
negative regulation of methylation-dependent chromatin silencing ISO
Inferred from Sequence Orthology
more info
 
somatic diversification of immunoglobulins ISO
Inferred from Sequence Orthology
more info
 
somatic hypermutation of immunoglobulin genes ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with exosome (RNase complex) ISO
Inferred from Sequence Orthology
more info
 
nucleus IC
Inferred by Curator
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
single-stranded DNA cytosine deaminase
Names
single-stranded DNA cytosine deaminase
cytidine aminohydrolase
activation induced deaminase
NP_033775.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009645.2NP_033775.1  single-stranded DNA cytosine deaminase

    See proteins identical to NP_033775.1

    Status: VALIDATED

    Source sequence(s)
    AF132979, BB221671, CJ161825
    Consensus CDS
    CCDS20497.1
    UniProtKB/Swiss-Prot
    Q9WVE0
    Related
    ENSMUSP00000040524, OTTMUSP00000047742, ENSMUST00000043301, OTTMUST00000087712
    Conserved Domains (3) summary
    pfam05240
    Location:119172
    Blast Score: 226
    APOBEC_C; APOBEC-like C-terminal domain
    cd01283
    Location:5129
    Blast Score: 150
    cytidine_deaminase; Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on ...
    pfam08210
    Location:11181
    Blast Score: 496
    APOBEC_N; APOBEC-like N-terminal domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000072.6 

    Range
    122553809..122564180
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000028.1 

    Range
    124348050..124358431
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Supplemental Content

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...