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    Aicda activation-induced cytidine deaminase [ Mus musculus (house mouse) ]

    Gene ID: 11628, updated on 7-Feb-2016
    Official Symbol
    Aicdaprovided by MGI
    Official Full Name
    activation-induced cytidine deaminaseprovided by MGI
    Primary source
    MGI:MGI:1342279
    See related
    Ensembl:ENSMUSG00000040627; Vega:OTTMUSG00000034572
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Aid; Arp2
    Orthologs
    See Aicda in Epigenomics, MapViewer
    Location:
    6; 6 F2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) 6 NC_000072.6 (122553809..122564180)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (122503827..122514198)

    Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene ribosomal modification protein rimK-like family member B Neighboring gene predicted pseudogene 8430 Neighboring gene microfibrillar associated protein 5 Neighboring gene voltage-dependent anion channel 1 pseudogene Neighboring gene apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    cytidine deaminase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytidine deaminase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cytidine deaminase activity ISO
    Inferred from Sequence Orthology
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    DNA demethylation ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to lipopolysaccharide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cytidine deamination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    isotype switching IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of methylation-dependent chromatin silencing ISO
    Inferred from Sequence Orthology
    more info
     
    somatic diversification of immunoglobulins ISO
    Inferred from Sequence Orthology
    more info
     
    somatic hypermutation of immunoglobulin genes ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with exosome (RNase complex) ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IC
    Inferred by Curator
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    single-stranded DNA cytosine deaminase
    Names
    activation induced deaminase
    cytidine aminohydrolase
    NP_033775.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009645.2NP_033775.1  single-stranded DNA cytosine deaminase

      See identical proteins and their annotated locations for NP_033775.1

      Status: VALIDATED

      Source sequence(s)
      AF132979, BB221671, CJ161825
      Consensus CDS
      CCDS20497.1
      UniProtKB/Swiss-Prot
      Q9WVE0
      Related
      ENSMUSP00000040524, OTTMUSP00000047742, ENSMUST00000043301, OTTMUST00000087712
      Conserved Domains (3) summary
      pfam05240
      Location:119172
      APOBEC_C; APOBEC-like C-terminal domain
      cd01283
      Location:5129
      cytidine_deaminase; Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on ...
      pfam08210
      Location:11181
      APOBEC_N; APOBEC-like N-terminal domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000072.6 Reference GRCm38.p3 C57BL/6J

      Range
      122553809..122564180
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000028.1 Alternate Mm_Celera

      Range
      124348050..124358431
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)