Display Settings:

Format

Send to:

Choose Destination
    • Showing Current items.

    Blmh bleomycin hydrolase [ Mus musculus (house mouse) ]

    Gene ID: 104184, updated on 4-Jul-2015
    Official Symbol
    Blmhprovided by MGI
    Official Full Name
    bleomycin hydrolaseprovided by MGI
    Primary source
    MGI:MGI:1345186
    See related
    Ensembl:ENSMUSG00000020840; Vega:OTTMUSG00000006244
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bh; Bmh; AI035728
    Summary
    The encoded protein is a cytoplasmic cysteine peptidase involved in inactivation of bleomycin, a glycopeptide which is a component of combination chemotherapy regimens for cancer. This encoded enzyme is highly conserved, and it contains the signature active site residues of cysteine protease papain superfamily enzymes. It is postulated that this enzyme has protective effects against bleomycin-induced pulmonary fibrosis and bleomycin tumor resistance. [provided by RefSeq, Jan 2010]
    Orthologs
    See Blmh in Epigenomics, MapViewer
    Location:
    11; 11 B5
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) 11 NC_000077.6 (76945656..76987389)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (76759158..76800891)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 40200 Neighboring gene transmembrane and immunoglobulin domain containing 1 Neighboring gene solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Neighboring gene predicted gene, 36676 Neighboring gene coiled-coil domain containing 55 Neighboring gene microRNA 423

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Clone Names

    • MGC36899, MGC37104, MGC39026

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    peptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    proteolysis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to drug IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to toxic substance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    bleomycin hydrolase
    Names
    BLM hydrolase
    NP_848760.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178645.4NP_848760.1  bleomycin hydrolase

      See identical proteins and their annotated locations for NP_848760.1

      Status: REVIEWED

      Source sequence(s)
      AK049461, BY087076, BY643607
      Consensus CDS
      CCDS25073.1
      UniProtKB/Swiss-Prot
      Q8R016
      Related
      ENSMUSP00000021197, OTTMUSP00000006555, ENSMUST00000021197, OTTMUST00000014100
      Conserved Domains (1) summary
      cd00585
      Location:6451
      Peptidase_C1B; Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p3 C57BL/6J

      Range
      76945656..76987389
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000033.1 Alternate Mm_Celera

      Range
      84444123..84485800
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)