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Flnb filamin, beta [ Mus musculus (house mouse) ]

Gene ID: 286940, updated on 20-Aug-2014
Official Symbol
Flnbprovided by MGI
Official Full Name
filamin, betaprovided by MGI
Primary source
MGI:2446089
See related
Ensembl:ENSMUSG00000025278; Vega:OTTMUSG00000036302
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fln-b; AL024016
See Flnb in Epigenomics, MapViewer
Location:
14 A1; 14
Exon count:
46
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 14 NC_000080.6 (7817957..7951588)

Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene predicted gene 10044 Neighboring gene predicted gene 8396 Neighboring gene deoxyribonuclease 1-like 3 Neighboring gene uncharacterized LOC102632075 Neighboring gene abhydrolase domain containing 6

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Antiviral mechanism by IFN-stimulated genes, organism-specific biosystem (from REACTOME)
    Antiviral mechanism by IFN-stimulated genes, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
    Cytokine Signaling in Immune system, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Focal adhesion, organism-specific biosystem (from KEGG)
    Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • Focal adhesion, conserved biosystem (from KEGG)
    Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • ISG15 antiviral mechanism, organism-specific biosystem (from REACTOME)
    ISG15 antiviral mechanism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Interferon Signaling, organism-specific biosystem (from REACTOME)
    Interferon Signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • MAPK signaling pathway, organism-specific biosystem (from KEGG)
    MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK signaling pathway, conserved biosystem (from KEGG)
    MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • Proteoglycans in cancer, organism-specific biosystem (from KEGG)
    Proteoglycans in cancer, organism-specific biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
  • Proteoglycans in cancer, conserved biosystem (from KEGG)
    Proteoglycans in cancer, conserved biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
  • Salmonella infection, organism-specific biosystem (from KEGG)
    Salmonella infection, organism-specific biosystemSalmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, S...
  • Salmonella infection, conserved biosystem (from KEGG)
    Salmonella infection, conserved biosystemSalmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, S...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
actin binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
poly(A) RNA binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
skeletal muscle tissue development IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm ISA
Inferred from Sequence Alignment
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
extracellular vesicular exosome ISO
Inferred from Sequence Orthology
more info
 
focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
stress fiber IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
filamin-B
Names
filamin-B
beta-filamin
ABP-280-like protein
actin binding protein 278
actin-binding-like protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081427.1NP_001074896.1  filamin-B isoform a

    See proteins identical to NP_001074896.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a). This gene lacks full-length transcript support, and therefore the exon combination of this variant is inferred based on tiled partial transcripts and full-length orthologous alignments, e.g., human AF043045.1.
    Source sequence(s)
    AA272439, AC140322, AK050046, BG076906, BP753071, BP753829, BP765788, BU055777, BU703688, BY101832, CA749811, CB290081, CD546916, CD549389, CD555839, CF165547, CF166040, CF536812, CF898917, CJ112968, CN534523, CV558093, DV653022, DV653075
    Consensus CDS
    CCDS70540.1
    UniProtKB/Swiss-Prot
    Q80X90
    Conserved Domains (2) summary
    smart00557
    Location:14211514
    Blast Score: 310
    IG_FLMN; Filamin-type immunoglobulin domains
    cd00014
    Location:17121
    Blast Score: 259
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
  2. NM_134080.1NP_598841.1  filamin-B isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a. This gene lacks full-length transcript support, and therefore the exon combination of this variant is inferred based on tiled partial transcripts and full-length orthologous alignments, e.g., human AB191258.1.
    Source sequence(s)
    AC140322, AK050046, BG076906, BM949278, BM950536, BP753072, BP765788, BU055777, BU703688, BY101832, CA537344, CB194973, CB290081, CD546916, CD549389, CD555839, CF165547, CF166040, CF172628, CF551577, CF736029, CJ112968, CN534523, CV558093
    Conserved Domains (2) summary
    smart00557
    Location:14211514
    Blast Score: 310
    IG_FLMN; Filamin-type immunoglobulin domains
    cd00014
    Location:17121
    Blast Score: 259
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000080.6 

    Range
    7817957..7951588
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006518049.1XP_006518112.1  

    Related
    ENSMUSP00000052020, OTTMUSP00000051606, ENSMUST00000052678, OTTMUST00000093156
    Conserved Domains (2) summary
    smart00557
    Location:14211514
    Blast Score: 310
    IG_FLMN; Filamin-type immunoglobulin domains
    cd00014
    Location:17121
    Blast Score: 259
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
  2. XM_006518050.1XP_006518113.1  

    See proteins identical to XP_006518113.1

    Conserved Domains (2) summary
    smart00557
    Location:14211514
    Blast Score: 310
    IG_FLMN; Filamin-type immunoglobulin domains
    cd00014
    Location:17121
    Blast Score: 259
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

Alternate Mm_Celera

Genomic

  1. AC_000036.1 

    Range
    3438528..3574962
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)