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    VCP valosin containing protein [ Homo sapiens (human) ]

    Gene ID: 7415, updated on 7-Feb-2016
    Official Symbol
    VCPprovided by HGNC
    Official Full Name
    valosin containing proteinprovided by HGNC
    Primary source
    HGNC:HGNC:12666
    See related
    Ensembl:ENSG00000165280; HPRD:03013; MIM:601023; Vega:OTTHUMG00000019855
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    p97; TERA; ALS14; IBMPFD; HEL-220; IBMPFD1; HEL-S-70
    Summary
    The protein encoded by this gene is a member of a family that includes putative ATP-binding proteins involved in vesicle transport and fusion, 26S proteasome function, and assembly of peroxisomes. This protein, as a structural protein, is associated with clathrin, and heat-shock protein Hsc70, to form a complex. It has been implicated in a number of cellular events that are regulated during mitosis, including homotypic membrane fusion, spindle pole body function, and ubiquitin-dependent protein degradation. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    9p13.3
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 9 NC_000009.12 (35056068..35072742, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (35056065..35072739, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376025 Neighboring gene chromosome 9 open reading frame 131 Neighboring gene Fanconi anemia complementation group G Neighboring gene phosphatidylinositol glycan anchor biosynthesis class O

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 is identified to have a physical interaction with valosin containing protein (VCP) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
    Vpu vpu A functional ER-associated degradation pathway is required for Vpu-induced tetherin degradation. P97 ATPase (VCP) knockdown partially impairs Vpu-mediated tetherin degradation PubMed
    vpu The VCP-UFD1L-NPL4 complex is required for HIV-1 Vpu-induced CD4 degradation in the ER-associated degradation pathway. The ATPase activity of VCP and ubiquitin binding to UFD1L are important for CD4 degradation by Vpu PubMed

    Go to the HIV-1, Human Interaction Database

    • Cellular response to heat stress, organism-specific biosystem (from REACTOME)
      Cellular response to heat stress, organism-specific biosystemIn response to exposure to elevated temperature and certain other proteotoxic stimuli (e.g., hypoxia, free radicals) cells activate a number of cytoprotective mechanisms known collectively as "heat s...
    • Cellular responses to stress, organism-specific biosystem (from REACTOME)
      Cellular responses to stress, organism-specific biosystemCells are subject to external molecular and physical stresses such as foreign molecules that perturb metabolic or signaling processes, and changes in temperature or pH. The ability of cells and tissu...
    • DNA Damage Bypass, organism-specific biosystem (from REACTOME)
      DNA Damage Bypass, organism-specific biosystemIn addition to various processes for removing lesions from the DNA, cells have developed specific mechanisms for tolerating unrepaired damage during the replication of the genome. These mechanisms ar...
    • DNA Repair, organism-specific biosystem (from REACTOME)
      DNA Repair, organism-specific biosystemDNA repair is a phenomenal multi-enzyme, multi-pathway system required to ensure the integrity of the cellular genome. Living organisms are constantly exposed to harmful metabolic by-products, enviro...
    • Disease, organism-specific biosystem (from REACTOME)
      Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
    • Diseases of signal transduction, organism-specific biosystem (from REACTOME)
      Diseases of signal transduction, organism-specific biosystemSignaling processes are central to human physiology (e.g., Pires-da Silva & Sommer 2003), and their disruption by either germ-line and somatic mutation can lead to serious disease. Here, the molecula...
    • HRD1/SEL1 ERAD complex, organism-specific biosystem (from KEGG)
      HRD1/SEL1 ERAD complex, organism-specific biosystemStructural complex; Genetic information processing; Protein processing
    • HRD1/SEL1 ERAD complex, conserved biosystem (from KEGG)
      HRD1/SEL1 ERAD complex, conserved biosystemStructural complex; Genetic information processing; Protein processing
    • HSF1 activation, organism-specific biosystem (from REACTOME)
      HSF1 activation, organism-specific biosystemHeat shock factor 1 (HSF1) is a transcription factor that activates gene expression in response to a variety of stresses, including heat shock, oxidative stress, as well as inflammation and infection...
    • Hedgehog ligand biogenesis, organism-specific biosystem (from REACTOME)
      Hedgehog ligand biogenesis, organism-specific biosystemMammalian genomes encode three Hedgehog ligands, Sonic Hedgehog (SHH), Indian Hedgehog (IHH) and Desert Hedgehog (DHH). These secreted morphogens can remain associated with lipid rafts on the surfac...
    • Hh mutants abrogate ligand secretion, organism-specific biosystem (from REACTOME)
      Hh mutants abrogate ligand secretion, organism-specific biosystemHh signaling is required for a number of developmental processes, and mutations that disrupt the normal processing and biogenesis of Hh ligand can result in neonatal abnormalities. SHH is one of a n...
    • Hh mutants that don't undergo autocatalytic processing are degraded by ERAD, organism-specific biosystem (from REACTOME)
      Hh mutants that don't undergo autocatalytic processing are degraded by ERAD, organism-specific biosystemHh signaling is required for a number of developmental processes, and mutations that disrupt the normal processing and biogenesis of Hh ligand can result in neonatal abnormalities. SHH is one of a n...
    • IL-9 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-9 Signaling Pathway, organism-specific biosystemInterleukin-9 belongs to a family of cytokines, which includes IL-2, IL-4, IL-7, IL-15 and IL-21. It signals through a receptor complex consisting of an IL-9 receptor (IL9R) and a common gamma chain ...
    • Legionellosis, organism-specific biosystem (from KEGG)
      Legionellosis, organism-specific biosystemLegionellosis is a potentially fatal infectious disease caused by the bacterium Legionella pneumophila and other legionella species. Two distinct clinical and epidemiological syndromes are associated...
    • Legionellosis, conserved biosystem (from KEGG)
      Legionellosis, conserved biosystemLegionellosis is a potentially fatal infectious disease caused by the bacterium Legionella pneumophila and other legionella species. Two distinct clinical and epidemiological syndromes are associated...
    • Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
    • Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by Hedgehog, organism-specific biosystem (from REACTOME)
      Signaling by Hedgehog, organism-specific biosystemHedgehog (Hh) is a secreted morphogen that regulates developmental processes in vertebrates including limb bud formation, neural tube patterning, cell growth and differentiation (reviewed in Hui and ...
    • Translesion Synthesis by POLH, organism-specific biosystem (from REACTOME)
      Translesion Synthesis by POLH, organism-specific biosystemDNA polymerase eta (POLH) consists of 713 amino acids and can bypass thymidine-thymidine dimers, correctly adding two dAMPs opposite to the lesion. Mutations in the POLH gene result in the loss of th...
    • Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template, organism-specific biosystem (from REACTOME)
      Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template, organism-specific biosystemUbiquitous environmental and endogenous genotoxic agents cause DNA lesions that can interfere with normal DNA metabolism including DNA replication, eventually resulting in mutations that lead to carc...
    • p97-Ufd1-Npl4 complex, organism-specific biosystem (from KEGG)
      p97-Ufd1-Npl4 complex, organism-specific biosystemStructural complex; Genetic information processing; Protein processing
    • p97-Ufd1-Npl4 complex, conserved biosystem (from KEGG)
      p97-Ufd1-Npl4 complex, conserved biosystemStructural complex; Genetic information processing; Protein processing
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Potential readthrough

    Included gene: FANCG

    Homology

    Clone Names

    • MGC8560, MGC131997, MGC148092

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ADP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATPase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    BAT3 complex binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    K48-linked polyubiquitin binding IEA
    Inferred from Electronic Annotation
    more info
     
    MHC class I protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    deubiquitinase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    poly(A) RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    polyubiquitin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ubiquitin-like protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ubiquitin-specific protease binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    ATP metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    DNA repair NAS
    Non-traceable Author Statement
    more info
    PubMed 
    DNA repair TAS
    Traceable Author Statement
    more info
     
    ER to Golgi vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
     
    ER-associated misfolded protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ER-associated ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ER-associated ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ER-associated ubiquitin-dependent protein catabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    ERAD pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NADH metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    activation of cysteine-type endopeptidase activity involved in apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    aggresome assembly IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to DNA damage stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to heat TAS
    Traceable Author Statement
    more info
     
    double-strand break repair IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum unfolded protein response TAS
    Traceable Author Statement
    more info
    PubMed 
    error-free translesion synthesis TAS
    Traceable Author Statement
    more info
     
    establishment of protein localization TAS
    Traceable Author Statement
    more info
    PubMed 
    flavin adenine dinucleotide catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of ATP biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of Lys63-specific deubiquitinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of mitochondrial membrane potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of oxidative phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein K63-linked deubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein complex assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    proteasome-mediated ubiquitin-dependent protein catabolic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    protein N-linked glycosylation via asparagine IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein hexamerization IEA
    Inferred from Electronic Annotation
    more info
     
    protein homooligomerization IEA
    Inferred from Electronic Annotation
    more info
     
    protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein ubiquitination NAS
    Non-traceable Author Statement
    more info
    PubMed 
    regulation of aerobic respiration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    retrograde protein transport, ER to cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    retrograde protein transport, ER to cytosol IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    translesion synthesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    translesion synthesis TAS
    Traceable Author Statement
    more info
     
    viral genome replication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    Derlin-1 retrotranslocation complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    VCP-NPL4-UFD1 AAA ATPase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    VCP-NPL4-UFD1 AAA ATPase complex TAS
    Traceable Author Statement
    more info
    PubMed 
    VCP-NSFL1C complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
    PubMed 
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular membrane-bounded organelle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    lipid particle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    myelin sheath IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus TAS
    Traceable Author Statement
    more info
    PubMed 
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    proteasome complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    site of double-strand break IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    transitional endoplasmic reticulum ATPase
    Names
    15S Mg(2+)-ATPase p97 subunit
    TER ATPase
    epididymis luminal protein 220
    epididymis secretory protein Li 70
    valosin-containing protein
    yeast Cdc48p homolog
    NP_009057.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_007887.1 RefSeqGene

      Range
      5001..21675
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_657

    mRNA and Protein(s)

    1. NM_007126.3NP_009057.1  transitional endoplasmic reticulum ATPase

      See identical proteins and their annotated locations for NP_009057.1

      Status: REVIEWED

      Source sequence(s)
      AI343015, BC007562, BC110913, DA880782, DB524539
      Consensus CDS
      CCDS6573.1
      UniProtKB/Swiss-Prot
      P55072
      UniProtKB/TrEMBL
      Q96IF9
      UniProtKB/TrEMBL
      V9HW80
      Related
      ENSP00000351777, OTTHUMP00000021326, ENST00000358901, OTTHUMT00000052290
      Conserved Domains (5) summary
      cd00009
      Location:480647
      AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
      pfam09336
      Location:718758
      Vps4_C; Vps4 C terminal oligomerization domain
      smart01072
      Location:131191
      CDC48_2; Cell division protein 48 (CDC48) domain 2
      pfam02359
      Location:25108
      CDC48_N; Cell division protein 48 (CDC48), N-terminal domain
      TIGR01243
      Location:25764
      CDC48; AAA family ATPase, CDC48 subfamily

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p2 Primary Assembly

      Range
      35056068..35072742 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018920.2 Alternate CHM1_1.1

      Range
      35055907..35072605 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)