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    Prkaa1 protein kinase, AMP-activated, alpha 1 catalytic subunit [ Mus musculus (house mouse) ]

    Gene ID: 105787, updated on 17-Jul-2016
    Official Symbol
    Prkaa1provided by MGI
    Official Full Name
    protein kinase, AMP-activated, alpha 1 catalytic subunitprovided by MGI
    Primary source
    MGI:MGI:2145955
    See related
    Ensembl:ENSMUSG00000050697
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI194361; AI450832; AL024255; AMPKalpha1; C130083N04Rik
    Orthologs
    Location:
    15; 15 A1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 15 NC_000081.6 (5143861..5181899)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (5093861..5131899)

    Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d pseudogene Neighboring gene predicted gene, 41256 Neighboring gene tetratricopeptide repeat domain 33 Neighboring gene heat shock protein 90, alpha (cytosolic), class A member 1 pseudogene Neighboring gene prostaglandin E receptor 4 (subtype EP4)

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    AMP-activated protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    AMP-activated protein kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    AMP-activated protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    [acetyl-CoA carboxylase] kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone serine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    tau-protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    autophagy IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to glucose starvation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to nutrient levels IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to prostaglandin E stimulus IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cholesterol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    cholesterol metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    cold acclimation ISO
    Inferred from Sequence Orthology
    more info
     
    covalent chromatin modification IEA
    Inferred from Electronic Annotation
    more info
     
    fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    fatty acid homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    fatty acid oxidation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glucose metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lipid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of TOR signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of glucose import in response to insulin stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of lipid catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of glycolytic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of skeletal muscle tissue development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein heterooligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of circadian rhythm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of energy homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of peptidyl-serine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
     
    response to UV IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to activity ISO
    Inferred from Sequence Orthology
    more info
     
    response to caffeine ISO
    Inferred from Sequence Orthology
    more info
     
    response to camptothecin IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to gamma radiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to hydrogen peroxide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    rhythmic process IEA
    Inferred from Electronic Annotation
    more info
     
    steroid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    steroid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    sterol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotide-activated protein kinase complex ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    5'-AMP-activated protein kinase catalytic subunit alpha-1
    Names
    ACACA kinase
    AMP-activated protein kinase, alpha 1 catalytic subunit
    AMPK subunit alpha-1
    HMGCR kinase
    acetyl-CoA carboxylase kinase
    hydroxymethylglutaryl-CoA reductase kinase
    tau-protein kinase PRKAA1
    NP_001013385.3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013367.3NP_001013385.3  5'-AMP-activated protein kinase catalytic subunit alpha-1

      See identical proteins and their annotated locations for NP_001013385.3

      Status: VALIDATED

      Source sequence(s)
      AC135079, AK081874, AK160612, BY134921, CB245934
      Consensus CDS
      CCDS49574.1
      UniProtKB/Swiss-Prot
      Q5EG47
      UniProtKB/TrEMBL
      Q3TUQ7, Q8BUX6
      Related
      ENSMUSP00000063166, ENSMUST00000051186
      Conserved Domains (4) summary
      cd12199
      Location:404557
      AMPKA1_C; C-terminal regulatory domain of 5'-AMP-activated protein kinase (AMPK) alpha 1 catalytic subunit
      smart00220
      Location:27279
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14403
      Location:296360
      UBA_AID_AAPK1; UBA-like autoinhibitory domain (AID) found in vertebrate 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPKalpha-1)
      cd14079
      Location:24279
      STKc_AMPK_alpha; Catalytic domain of the Alpha subunit of the Serine/Threonine Kinase, AMP-activated protein kinase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000081.6 Reference GRCm38.p4 C57BL/6J

      Range
      5143861..5181899
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006519953.2XP_006520016.1  

      Conserved Domains (4) summary
      cd12199
      Location:260413
      AMPKA1_C; C-terminal regulatory domain of 5'-AMP-activated protein kinase (AMPK) alpha 1 catalytic subunit
      smart00220
      Location:2135
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14403
      Location:152216
      UBA_AID_AAPK1; UBA-like autoinhibitory domain (AID) found in vertebrate 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPKalpha-1)
      cl21453
      Location:1135
      PKc_like; Protein Kinases, catalytic domain
    2. XM_017316356.1XP_017171845.1  

      Conserved Domains (4) summary
      cd12199
      Location:303456
      AMPKA1_C; C-terminal regulatory domain of 5'-AMP-activated protein kinase (AMPK) alpha 1 catalytic subunit
      smart00220
      Location:1178
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14403
      Location:195259
      UBA_AID_AAPK1; UBA-like autoinhibitory domain (AID) found in vertebrate 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPKalpha-1)
      cl21453
      Location:1178
      PKc_like; Protein Kinases, catalytic domain
    3. XM_011245321.2XP_011243623.1  

      See identical proteins and their annotated locations for XP_011243623.1

      Conserved Domains (4) summary
      cd12199
      Location:303456
      AMPKA1_C; C-terminal regulatory domain of 5'-AMP-activated protein kinase (AMPK) alpha 1 catalytic subunit
      smart00220
      Location:1178
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14403
      Location:195259
      UBA_AID_AAPK1; UBA-like autoinhibitory domain (AID) found in vertebrate 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPKalpha-1)
      cl21453
      Location:1178
      PKc_like; Protein Kinases, catalytic domain