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RRP6 Rrp6p [ Saccharomyces cerevisiae S288c ]

Gene ID: 854162, updated on 22-Aug-2014
Gene symbol
RRP6
Gene description
Rrp6p
Primary source
SGD:S000005527
Locus tag
YOR001W
Gene type
protein coding
RNA name
Rrp6p
RefSeq status
PROVISIONAL
Organism
Saccharomyces cerevisiae S288c (strain: S288c)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
See RRP6 in MapViewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (326832..329033)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Izh2p Neighboring gene Pho80p Neighboring gene dolichyl-P-Glc:Man(9)GlcNAc(2)-PP-dolichol alpha-1,3-glucosyltransferase Neighboring gene putative subtilisin-like protease YSP3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • RNA degradation, organism-specific biosystem (from KEGG)
    RNA degradation, organism-specific biosystemThe correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay e...
  • RNA degradation, conserved biosystem (from KEGG)
    RNA degradation, conserved biosystemThe correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay e...
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
3'-5' exonuclease activity IEA
Inferred from Electronic Annotation
more info
 
3'-5'-exoribonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
RNA binding IEA
Inferred from Electronic Annotation
more info
 
catalytic activity IEA
Inferred from Electronic Annotation
more info
 
exonuclease activity IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
nuclease activity IEA
Inferred from Electronic Annotation
more info
 
nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
RNA processing IEA
Inferred from Electronic Annotation
more info
 
U1 snRNA 3'-end processing IGI
Inferred from Genetic Interaction
more info
PubMed 
U1 snRNA 3'-end processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
U4 snRNA 3'-end processing IGI
Inferred from Genetic Interaction
more info
PubMed 
U4 snRNA 3'-end processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
U5 snRNA 3'-end processing IGI
Inferred from Genetic Interaction
more info
PubMed 
U5 snRNA 3'-end processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular metabolic process IEA
Inferred from Electronic Annotation
more info
 
exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
Inferred from Mutant Phenotype
more info
PubMed 
histone mRNA catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
nuclear polyadenylation-dependent CUT catabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
nuclear polyadenylation-dependent CUT catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
nuclear polyadenylation-dependent antisense transcript catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
nuclear polyadenylation-dependent mRNA catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
nuclear polyadenylation-dependent rRNA catabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
nuclear polyadenylation-dependent rRNA catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
nuclear polyadenylation-dependent snRNA catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
nuclear polyadenylation-dependent snoRNA catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
nuclear polyadenylation-dependent tRNA catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
nuclear polyadenylation-dependent tRNA catabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
nuclear retention of pre-mRNA at the site of transcription IGI
Inferred from Genetic Interaction
more info
PubMed 
nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription IGI
Inferred from Genetic Interaction
more info
PubMed 
nucleobase-containing compound metabolic process IEA
Inferred from Electronic Annotation
more info
 
polyadenylation-dependent snoRNA 3'-end processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery IMP
Inferred from Mutant Phenotype
more info
PubMed 
rRNA processing IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
exosome (RNase complex) IEA
Inferred from Electronic Annotation
more info
 
intracellular IEA
Inferred from Electronic Annotation
more info
 
nuclear exosome (RNase complex) IDA
Inferred from Direct Assay
more info
PubMed 
nuclear exosome (RNase complex) IEA
Inferred from Electronic Annotation
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
Names
Rrp6p
NP_014643.1
  • Nuclear exosome exonuclease component; has 3'-5' exonuclease activity that is regulated by Lrp1p; involved in RNA processing, maturation, surveillance, degradation, tethering, and export; role in sn/snoRNAs precursor degradation; forms a stable heterodimer with Lrp1p; has similarity to E. coli RNase D and to human PM-Sc1 100 (EXOSC10); mutant displays reduced transcription elongation in the G-less-based

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 

    Range
    326832..329033
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183420.1NP_014643.1  Rrp6p [Saccharomyces cerevisiae S288c]

    See proteins identical to NP_014643.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q12149
    Conserved Domains (4) summary
    cd06147
    Location:209399
    Blast Score: 899
    Rrp6p_like_exo; DEDDy 3'-5' exonuclease domain of yeast Rrp6p, human polymyositis/scleroderma autoantigen 100kDa, and similar proteins
    smart00341
    Location:435515
    Blast Score: 190
    HRDC; Helicase and RNase D C-terminal
    COG0349
    Location:216622
    Blast Score: 900
    Rnd; Ribonuclease D [Translation, ribosomal structure and biogenesis]
    pfam08066
    Location:13102
    Blast Score: 260
    PMC2NT; PMC2NT (NUC016) domain