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Hnf4a hepatic nuclear factor 4, alpha [ Mus musculus (house mouse) ]

Gene ID: 15378, updated on 26-Aug-2014
Official Symbol
Hnf4aprovided by MGI
Official Full Name
hepatic nuclear factor 4, alphaprovided by MGI
Primary source
MGI:109128
Locus tag
RP23-36P22.1
See related
Ensembl:ENSMUSG00000017950; Vega:OTTMUSG00000001071
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hnf4; HNF-4; MODY1; Nr2a1; Tcf14; Hnf4alpha
See Hnf4a in Epigenomics, MapViewer
Location:
2 H3; 2 84.32 cM
Exon count:
11
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 2 NC_000068.7 (163506809..163572907)

Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2310001K24 gene Neighboring gene fat storage-inducing transmembrane protein 2 Neighboring gene R3H domain containing-like Neighboring gene hepatic nuclear factor 4 alpha, opposite strand Neighboring gene Crx opposite strand transcript 1 pseudogene Neighboring gene tocopherol (alpha) transfer protein-like

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
DNA binding ISO
Inferred from Sequence Orthology
more info
PubMed 
RNA polymerase II activating transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II core promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
fatty acid binding ISO
Inferred from Sequence Orthology
more info
 
fatty-acyl-CoA binding ISO
Inferred from Sequence Orthology
more info
 
ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
palmitoyl-CoA hydrolase activity ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
receptor binding ISO
Inferred from Sequence Orthology
more info
 
repressing transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
sequence-specific DNA binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific DNA binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
PubMed 
steroid hormone receptor activity IEA
Inferred from Electronic Annotation
more info
 
transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
transcription regulatory region DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
transcription regulatory region DNA binding ISO
Inferred from Sequence Orthology
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
SMAD protein signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
acyl-CoA metabolic process ISO
Inferred from Sequence Orthology
more info
 
blood coagulation ISO
Inferred from Sequence Orthology
more info
 
cell differentiation ISO
Inferred from Sequence Orthology
more info
 
cell-cell junction organization ISO
Inferred from Sequence Orthology
more info
 
establishment of tissue polarity ISO
Inferred from Sequence Orthology
more info
 
glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
lipid homeostasis ISO
Inferred from Sequence Orthology
more info
 
lipid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
negative regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein import into nucleus, translocation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of sequence-specific DNA binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of tyrosine phosphorylation of Stat5 protein ISO
Inferred from Sequence Orthology
more info
 
ornithine metabolic process ISO
Inferred from Sequence Orthology
more info
 
phospholipid homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cholesterol homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of fatty acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gluconeogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
regulation of gastrulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of insulin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of lipid metabolic process ISO
Inferred from Sequence Orthology
more info
 
regulation of microvillus assembly ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription from RNA polymerase II promoter IGI
Inferred from Genetic Interaction
more info
 
regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
 
regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
response to glucose IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to glucose ISO
Inferred from Sequence Orthology
more info
 
sex differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
signal transduction involved in regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
steroid hormone mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
triglyceride homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
xenobiotic metabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
transcription factor complex ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
hepatocyte nuclear factor 4-alpha
Names
hepatocyte nuclear factor 4-alpha
TCF-14
HNF4 alpha
HNF-4-alpha
HNF4alpha10
HNF4alpha11
HNF4alpha12
Nuclear receptor 2A1
transcription factor 14
transcription factor HNF-4
nuclear receptor subfamily 2 group A member 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008261.2NP_032287.2  hepatocyte nuclear factor 4-alpha

    See proteins identical to NP_032287.2

    Status: PROVISIONAL

    Source sequence(s)
    BC039220
    Consensus CDS
    CCDS17012.1
    UniProtKB/Swiss-Prot
    P49698
    Related
    ENSMUSP00000018094, ENSMUST00000018094
    Conserved Domains (2) summary
    cd06931
    Location:151373
    Blast Score: 1130
    NR_LBD_HNF4_like; The ligand binding domain of heptocyte nuclear factor 4, which is explosively expanded in nematodes
    cd06960
    Location:60135
    Blast Score: 423
    NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000068.7 

    Range
    163506809..163572907
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498788.1XP_006498851.1  

    See proteins identical to XP_006498851.1

    Conserved Domains (2) summary
    cd06931
    Location:129351
    Blast Score: 1132
    NR_LBD_HNF4_like; The ligand binding domain of heptocyte nuclear factor 4, which is explosively expanded in nematodes
    cd06960
    Location:38113
    Blast Score: 421
    NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
  2. XM_006498787.1XP_006498850.1  

    UniProtKB/Swiss-Prot
    P49698
    Conserved Domains (2) summary
    cd06931
    Location:151373
    Blast Score: 1129
    NR_LBD_HNF4_like; The ligand binding domain of heptocyte nuclear factor 4, which is explosively expanded in nematodes
    cd06960
    Location:60135
    Blast Score: 426
    NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers

Alternate Mm_Celera

Genomic

  1. AC_000024.1 

    Range
    169490574..169516277
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)