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    NUMA1 nuclear mitotic apparatus protein 1 [ Homo sapiens (human) ]

    Gene ID: 4926, updated on 22-Sep-2016
    Official Symbol
    NUMA1provided by HGNC
    Official Full Name
    nuclear mitotic apparatus protein 1provided by HGNC
    Primary source
    HGNC:HGNC:8059
    See related
    Ensembl:ENSG00000137497 HPRD:01236; MIM:164009; Vega:OTTHUMG00000167697
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NUMA; NMP-22
    Summary
    This gene encodes a large protein that forms a structural component of the nuclear matrix. The encoded protein interacts with microtubules and plays a role in the formation and organization of the mitotic spindle during cell division. Chromosomal translocation of this gene with the RARA (retinoic acid receptor, alpha) gene on chromosome 17 have been detected in patients with acute promyelocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]
    Orthologs
    Location:
    11q13
    Exon count:
    38
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 11 NC_000011.10 (72002864..72080693, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (71713910..71791732, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene transient receptor potential cation channel, subfamily C, member 2-like Neighboring gene olfactory receptor family 7 subfamily E member 126 pseudogene Neighboring gene ring finger protein 121 Neighboring gene uncharacterized LOC100128494 Neighboring gene interleukin 18 binding protein Neighboring gene microRNA 3165 Neighboring gene leucine rich transmembrane and O-methyltransferase domain containing Neighboring gene late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 Neighboring gene anaphase promoting complex subunit 15

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Interaction of HIV-1 Tat with NUMA1 in T-cells is identified by a proteomic strategy based on affinity chromatography PubMed
    retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human nuclear mitotic apparatus protein 1 (NUMA1) at amino acid residues 2054-2055 by the HIV-1 protease PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    microtubule binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    structural molecule activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    establishment of mitotic spindle orientation IEA
    Inferred from Electronic Annotation
    more info
     
    lung epithelial cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    mitotic nuclear division IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus organization TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    apical part of cell IEA
    Inferred from Electronic Annotation
    more info
     
    cell cortex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitotic spindle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitotic spindle astral microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitotic spindle pole IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear matrix IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    spindle TAS
    Traceable Author Statement
    more info
    PubMed 
    spindle microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    spindle pole IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    nuclear mitotic apparatus protein 1
    Names
    SP-H antigen
    centrophilin stabilizes mitotic spindle in mitotic cells
    nuclear matrix protein-22
    structural nuclear protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286561.1NP_001273490.1  nuclear mitotic apparatus protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001273490.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AB210007, BC004165, BG754891, BG771637, Z11583, Z11584
      Consensus CDS
      CCDS66156.1
      UniProtKB/Swiss-Prot
      Q14980
      UniProtKB/TrEMBL
      A0A024R5M9, Q4LE64
      Related
      ENSP00000351851, OTTHUMP00000236522, ENST00000358965, OTTHUMT00000395695
      Conserved Domains (2) summary
      TIGR02168
      Location:10151717
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam01576
      Location:2541329
      Myosin_tail_1; Myosin tail
    2. NM_006185.3NP_006176.2  nuclear mitotic apparatus protein 1 isoform 1

      See identical proteins and their annotated locations for NP_006176.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AB210007, BC004165, BC027493, BG754891, BG771637
      Consensus CDS
      CCDS31633.1
      UniProtKB/Swiss-Prot
      Q14980
      UniProtKB/TrEMBL
      Q3SYK8, Q4LE64
      Related
      ENSP00000377298, OTTHUMP00000236571, ENST00000393695, OTTHUMT00000395769
      Conserved Domains (2) summary
      TIGR02168
      Location:10151731
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam01576
      Location:2541329
      Myosin_tail_1; Myosin tail

    RNA

    1. NR_104476.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' terminal exon and lacks two alternate internal exons, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the reading frame found in variant 1.
      Source sequence(s)
      BC004165, BC103765, BG754891
      Related
      ENST00000351960, OTTHUMT00000395768

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p7 Primary Assembly

      Range
      72002864..72080693 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011545055.1XP_011543357.1  

      See identical proteins and their annotated locations for XP_011543357.1

      Conserved Domains (1) summary
      pfam01576
      Location:145986
      Myosin_tail_1; Myosin tail
    2. XM_011545056.2XP_011543358.1  

      See identical proteins and their annotated locations for XP_011543358.1

      Conserved Domains (1) summary
      pfam01576
      Location:145986
      Myosin_tail_1; Myosin tail
    3. XM_011545057.2XP_011543359.1  

      See identical proteins and their annotated locations for XP_011543359.1

      Conserved Domains (1) summary
      pfam01576
      Location:145986
      Myosin_tail_1; Myosin tail
    4. XM_011545060.2XP_011543362.1  

      See identical proteins and their annotated locations for XP_011543362.1

      Conserved Domains (1) summary
      pfam01576
      Location:145986
      Myosin_tail_1; Myosin tail
    5. XM_011545059.2XP_011543361.1  

      See identical proteins and their annotated locations for XP_011543361.1

      Conserved Domains (1) summary
      pfam01576
      Location:145986
      Myosin_tail_1; Myosin tail
    6. XM_011545058.1XP_011543360.1  

      See identical proteins and their annotated locations for XP_011543360.1

      Conserved Domains (1) summary
      pfam01576
      Location:145986
      Myosin_tail_1; Myosin tail
    7. XM_011545062.2XP_011543364.1  

      See identical proteins and their annotated locations for XP_011543364.1

      Conserved Domains (1) summary
      pfam01576
      Location:145986
      Myosin_tail_1; Myosin tail
    8. XM_011545066.1XP_011543368.1  

      See identical proteins and their annotated locations for XP_011543368.1

      UniProtKB/TrEMBL
      A0A024R5M9
      Related
      ENSP00000478624, ENST00000620566
      Conserved Domains (2) summary
      TIGR02168
      Location:10151717
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam01576
      Location:2541329
      Myosin_tail_1; Myosin tail
    9. XM_011545065.1XP_011543367.1  

      Conserved Domains (1) summary
      pfam01576
      Location:145986
      Myosin_tail_1; Myosin tail
    10. XM_006718564.1XP_006718627.1  

      See identical proteins and their annotated locations for XP_006718627.1

      UniProtKB/Swiss-Prot
      Q14980
      UniProtKB/TrEMBL
      Q4LE64
      Conserved Domains (2) summary
      TIGR02168
      Location:10151731
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam01576
      Location:2541329
      Myosin_tail_1; Myosin tail
    11. XM_011545054.1XP_011543356.1  

      See identical proteins and their annotated locations for XP_011543356.1

      Conserved Domains (1) summary
      pfam01576
      Location:145986
      Myosin_tail_1; Myosin tail
    12. XM_011545064.1XP_011543366.1  

      See identical proteins and their annotated locations for XP_011543366.1

      Conserved Domains (1) summary
      pfam01576
      Location:145986
      Myosin_tail_1; Myosin tail
    13. XM_011545061.2XP_011543363.1  

      See identical proteins and their annotated locations for XP_011543363.1

      Conserved Domains (1) summary
      pfam01576
      Location:145986
      Myosin_tail_1; Myosin tail
    14. XM_011545063.2XP_011543365.1  

      See identical proteins and their annotated locations for XP_011543365.1

      Conserved Domains (1) summary
      pfam01576
      Location:145986
      Myosin_tail_1; Myosin tail
    15. XM_017017830.1XP_016873319.1  

      Conserved Domains (2) summary
      TIGR02168
      Location:10151717
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam01576
      Location:2541329
      Myosin_tail_1; Myosin tail
    16. XM_017017831.1XP_016873320.1  

      Conserved Domains (2) summary
      TIGR02168
      Location:10151717
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam01576
      Location:2541329
      Myosin_tail_1; Myosin tail

    Alternate CHM1_1.1

    Genomic

    1. NC_018922.2 Alternate CHM1_1.1

      Range
      71597789..71675562 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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