Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    Nf1 Neurofibromin 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43149, updated on 5-Jun-2016
    Official Symbol
    Nf1provided by FlyBase
    Official Full Name
    Neurofibromin 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0015269
    Locus tag
    Dmel_CG8318
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster (old-lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8318; Dmel\CG8318; dNf1; dNF1; Nf-1; NF-1; nf1; NF1
    Location:
    96F9-96F9
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    Release 6.07 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (25983013..25995737)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (21808735..21821459)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene bride of sevenless Neighboring gene CG42261 gene product from transcript CG42261-RB Neighboring gene Enhancer of split mdelta, helix-loop-helix Neighboring gene CG43116 gene product from transcript CG43116-RA

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Homology

    • Homologs of the Nf1 gene: The Nf1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, mouse, rat, chicken, zebrafish, mosquito, and frog.

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    GTPase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    Ras protein signal transduction IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cAMP-mediated signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    locomotor rhythm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    long-term memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of synaptic growth at neuromuscular junction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    olfactory learning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    perineurial glial growth IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of adenylate cyclase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of Ras protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to heat IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    short-term memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Preferred Names
    CG8318 gene product from transcript CG8318-RD
    Names
    CG8318-PB
    CG8318-PC
    CG8318-PD
    CG8318-PE
    CG8318-PF
    Neurofibromatosis-1
    Nf1-PB
    Nf1-PC
    Nf1-PD
    Nf1-PE
    Nf1-PF
    neurofibramatosis-1
    neurofibromatosis 1
    neurofibromatosis factor 1
    neurofibromatosis type 1
    neurofibromin
    neurofibromin 1
    NP_733132.2
    • unusual splice

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      25983013..25995737
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001014668.2NP_001014668.1  neurofibromin 1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014668.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q59DT9
      Related
      FBpp0100151, FBtr0100113
      Conserved Domains (5) summary
      cd05130
      Location:12421575
      RasGAP_Neurofibromin; Ras-GTPase Activating Domain of neurofibromin
      smart00323
      Location:12271581
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cd00170
      Location:16121758
      SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
      pfam14228
      Location:19312108
      MOR2-PAG1_mid; Cell morphogenesis central region
      cd13313
      Location:17591868
      PH_NF1; Neurofibromin-1 Pleckstrin homology-like domain
    2. NM_001276049.1NP_001262978.1  neurofibromin 1, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262978.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KI28
      Related
      FBpp0303215, FBtr0330182
      Conserved Domains (5) summary
      cd05130
      Location:12421575
      RasGAP_Neurofibromin; Ras-GTPase Activating Domain of neurofibromin
      smart00323
      Location:12271581
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cd00170
      Location:16121758
      SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
      pfam14228
      Location:19312108
      MOR2-PAG1_mid; Cell morphogenesis central region
      cd13313
      Location:17591868
      PH_NF1; Neurofibromin-1 Pleckstrin homology-like domain
    3. NM_001276050.1NP_001262979.1  neurofibromin 1, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262979.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHX4
      Related
      FBpp0303216, FBtr0330183
      Conserved Domains (5) summary
      cd05130
      Location:12421575
      RasGAP_Neurofibromin; Ras-GTPase Activating Domain of neurofibromin
      smart00323
      Location:12271581
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cd00170
      Location:16121758
      SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
      pfam14228
      Location:19312108
      MOR2-PAG1_mid; Cell morphogenesis central region
      cd13313
      Location:17591868
      PH_NF1; Neurofibromin-1 Pleckstrin homology-like domain
    4. NM_170252.3NP_733131.2  neurofibromin 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733131.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IMS2
      Related
      FBpp0084327, FBtr0084953
      Conserved Domains (5) summary
      cd05130
      Location:12421575
      RasGAP_Neurofibromin; Ras-GTPase Activating Domain of neurofibromin
      smart00323
      Location:12271581
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cd00170
      Location:16121758
      SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
      pfam14228
      Location:19312108
      MOR2-PAG1_mid; Cell morphogenesis central region
      cd13313
      Location:17591868
      PH_NF1; Neurofibromin-1 Pleckstrin homology-like domain
    5. NM_170253.2NP_733132.2  neurofibromin 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733132.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VBJ2
      Related
      FBpp0084326, FBtr0084952
      Conserved Domains (5) summary
      cd05130
      Location:12421575
      RasGAP_Neurofibromin; Ras-GTPase Activating Domain of neurofibromin
      smart00323
      Location:12271581
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cd00170
      Location:16121758
      SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
      pfam14228
      Location:19312108
      MOR2-PAG1_mid; Cell morphogenesis central region
      cd13313
      Location:17591868
      PH_NF1; Neurofibromin-1 Pleckstrin homology-like domain