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SLC14A2 solute carrier family 14 (urea transporter), member 2 [ Homo sapiens (human) ]

Gene ID: 8170, updated on 3-May-2015
Official Symbol
SLC14A2provided by HGNC
Official Full Name
solute carrier family 14 (urea transporter), member 2provided by HGNC
Primary source
HGNC:HGNC:10919
See related
Ensembl:ENSG00000132874; HPRD:03366; MIM:601611; Vega:OTTHUMG00000132616
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UT2; UTA; UTR; HUT2; UT-A2; hUT-A6
Summary
The protein encoded by this gene belongs to the urea transporter family. In mammalian cells, urea is the chief end product of nitrogen catabolism, and plays an important role in the urinary concentration mechanism. This protein is expressed in the inner medulla of the kidney, and mediates rapid transepithelial urea transport across the inner medullary collecting duct. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2011]
Orthologs
See SLC14A2 in MapViewer
Location:
18q12.1-q21.1
Exon count:
23
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 18 NC_000018.10 (45212957..45683107)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (42792947..43263072)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372091 Neighboring gene uncharacterized LOC101927961 Neighboring gene SLC14A2 antisense RNA 1 Neighboring gene uncharacterized LOC105372092 Neighboring gene uncharacterized LOC105372093 Neighboring gene solute carrier family 14 (urea transporter), member 1 (Kidd blood group)

Related articles in PubMed

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association study of biochemical traits in Korcula Island, Croatia.
NHGRI GWA Catalog
Genome-wide association study of hematological and biochemical traits in a Japanese population.
NHGRI GWA Catalog
Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits.
NHGRI GWA Catalog
Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations.
NHGRI GWA Catalog
Six novel susceptibility Loci for early-onset androgenetic alopecia and their unexpected association with common diseases.
NHGRI GWA Catalog
Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.
NHGRI GWA Catalog

Markers

Homology

Clone Names

  • FLJ16167, MGC119566, MGC119567

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cell adhesion molecule binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
urea transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
transmembrane transport TAS
Traceable Author Statement
more info
 
urea transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
urea transport TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
urea transporter 2
Names
urea transporter 2
solute carrier family 14 member 2
urea transporter, kidney
urea transporter-2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001242692.1NP_001229621.1  urea transporter 2

    See identical proteins and their annotated locations for NP_001229621.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC023421, AK292422, DB045789, DR002593
    Consensus CDS
    CCDS11924.1
    UniProtKB/Swiss-Prot
    Q15849
    Related
    ENSP00000465953, OTTHUMP00000260584, ENST00000586448, OTTHUMT00000444508
    Conserved Domains (1) summary
    pfam03253
    Location:579865
    UT; Urea transporter
  2. NM_007163.3NP_009094.3  urea transporter 2

    See identical proteins and their annotated locations for NP_009094.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC023421, AF349446, BC110445, BC110446, DR002593, X96969
    Consensus CDS
    CCDS11924.1
    UniProtKB/Swiss-Prot
    Q15849
    Related
    ENSP00000255226, OTTHUMP00000163451, ENST00000255226, OTTHUMT00000255858
    Conserved Domains (1) summary
    pfam03253
    Location:579865
    UT; Urea transporter

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p2 Primary Assembly

    Range
    45212957..45683107
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526216.1XP_011524518.1  

    See identical proteins and their annotated locations for XP_011524518.1

    Conserved Domains (1) summary
    pfam03253
    Location:579865
    UT; Urea transporter
  2. XM_011526217.1XP_011524519.1  

    Conserved Domains (1) summary
    pfam03253
    Location:534820
    UT; Urea transporter

Alternate CHM1_1.1

Genomic

  1. NC_018929.2 Alternate CHM1_1.1

    Range
    42719963..43190313
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)