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PLXNA2 plexin A2 [ Homo sapiens (human) ]

Gene ID: 5362, updated on 13-Jan-2015
Official Symbol
PLXNA2provided by HGNC
Official Full Name
plexin A2provided by HGNC
Primary source
HGNC:HGNC:9100
Locus tag
RP11-328D5.3
See related
Ensembl:ENSG00000076356; HPRD:03033; MIM:601054; Vega:OTTHUMG00000036564
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OCT; PLXN2
Summary
This gene encodes a member of the plexin-A family of semaphorin co-receptors. Semaphorins are a large family of secreted or membrane-bound proteins that mediate repulsive effects on axon pathfinding during nervous system development. A subset of semaphorins are recognized by plexin-A/neuropilin transmembrane receptor complexes, triggering a cellular signal transduction cascade that leads to axon repulsion. This plexin-A family member is thought to transduce signals from semaphorin-3A and -3C. [provided by RefSeq, Jul 2008]
Orthologs
See PLXNA2 in Epigenomics, MapViewer
Location:
1q32.2
Exon count:
35
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 1 NC_000001.11 (208022242..208244320, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (208195587..208417665, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101929385 Neighboring gene uncharacterized LOC148696 Neighboring gene CD34 molecule Neighboring gene ribosomal protein S26 pseudogene 13 Neighboring gene uncharacterized LOC100509303

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Hypertrophy-associated polymorphisms ascertained in a founder cohort applied to heart failure risk and mortality.
NHGRI GWA Catalog
  • Axon guidance, organism-specific biosystem (from KEGG)
    Axon guidance, organism-specific biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
  • Axon guidance, conserved biosystem (from KEGG)
    Axon guidance, conserved biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
  • Axon guidance, organism-specific biosystem (from REACTOME)
    Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
  • CRMPs in Sema3A signaling, organism-specific biosystem (from REACTOME)
    CRMPs in Sema3A signaling, organism-specific biosystemCRMPs are a small family of plexinA-interacting cytosolic phosphoproteins identified as mediators of Sema3A signaling and neuronal differentiation. After Sema3A activation Plexin-A bound CRMP's under...
  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
  • Other semaphorin interactions, organism-specific biosystem (from REACTOME)
    Other semaphorin interactions, organism-specific biosystemThere are eight classes of semaphorins and four types of plexins. Semaphorin (SEMA) classes 1 and 2 are found in invertebrates and classes 3-7 are vertebrate sempahorines. Sempahorin class 3 is secre...
  • SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion, organism-specific biosystem (from REACTOME)
    SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion, organism-specific biosystemSema3A, a prototypical semaphorin, acts as a chemorepellent or a chemoattractant for axons by activating a receptor complex comprising neuropilin-1 as the ligand-binding subunit and plexin-A1 as the ...
  • Sema3A PAK dependent Axon repulsion, organism-specific biosystem (from REACTOME)
    Sema3A PAK dependent Axon repulsion, organism-specific biosystemActivated Rac1 bound to plexin-A might modulate actin dynamics through the sequential phosphorylation and activation of PAK, LIMK1 and cofilin.
  • Semaphorin interactions, organism-specific biosystem (from REACTOME)
    Semaphorin interactions, organism-specific biosystemSemaphorins are a large family of cell surface and secreted guidance molecules divided into eight classes on the basis of their structures. They all have an N-terminal conserved sema domain. Semaphor...
  • Spinal Cord Injury, organism-specific biosystem (from WikiPathways)
    Spinal Cord Injury, organism-specific biosystemThis pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multistep process that...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ11751, FLJ30634, KIAA0463

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
semaphorin receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
axon guidance TAS
Traceable Author Statement
more info
 
centrosome localization IEA
Inferred from Electronic Annotation
more info
 
cerebellar granule cell precursor tangential migration IEA
Inferred from Electronic Annotation
more info
 
limb bud formation IEA
Inferred from Electronic Annotation
more info
 
neural tube development IEA
Inferred from Electronic Annotation
more info
 
pharyngeal system development IEA
Inferred from Electronic Annotation
more info
 
regulation of cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
semaphorin-plexin signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
somitogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
intracellular IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
semaphorin receptor complex TAS
Traceable Author Statement
more info
PubMed 
Preferred Names
plexin-A2
Names
plexin-A2
plexin 2
semaphorin receptor OCT
transmembrane protein OCT

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025179.3NP_079455.3  plexin-A2 precursor

    See proteins identical to NP_079455.3

    Status: REVIEWED

    Source sequence(s)
    AB007932, AL356275, AL544219, AL606753, DA500239, H11743, X87831
    Consensus CDS
    CCDS31013.1
    UniProtKB/Swiss-Prot
    O75051
    Related
    ENSP00000356000, OTTHUMP00000034732, ENST00000367033, OTTHUMT00000088932
    Conserved Domains (8) summary
    cd11272
    Location:38552
    Sema_plexin_A2; The Sema domain, a protein interacting module, of Plexin A2
    cd12790
    Location:13111888
    RasGAP_plexin_A; Ras-GTPase Activating Domain of type A plexins
    smart00630
    Location:50483
    Sema; semaphorin domain
    cd00603
    Location:11431218
    IPT_PCSR; IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the ...
    cd01179
    Location:9541037
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:858953
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01181
    Location:10411141
    IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    pfam01437
    Location:655702
    PSI; Plexin repeat

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000001.11 

    Range
    208022242..208244320
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005273164.1XP_005273221.1  

    Conserved Domains (8) summary
    cd11272
    Location:53567
    Sema_plexin_A2; The Sema domain, a protein interacting module, of Plexin A2
    cd12790
    Location:13261968
    RasGAP_plexin_A; Ras-GTPase Activating Domain of type A plexins
    smart00630
    Location:65498
    Sema; semaphorin domain
    cd00603
    Location:11581233
    IPT_PCSR; IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the ...
    cd01179
    Location:9691052
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:873968
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01181
    Location:10561156
    IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    pfam01437
    Location:670717
    PSI; Plexin repeat
  2. XM_006711387.1XP_006711450.1  

    Conserved Domains (8) summary
    pfam08337
    Location:13251821
    Plexin_cytopl; Plexin cytoplasmic RasGAP domain
    cd11272
    Location:53567
    Sema_plexin_A2; The Sema domain, a protein interacting module, of Plexin A2
    smart00630
    Location:65498
    Sema; semaphorin domain
    cd00603
    Location:11581233
    IPT_PCSR; IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the ...
    cd01179
    Location:9691052
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:873968
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01181
    Location:10561156
    IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    pfam01437
    Location:670717
    PSI; Plexin repeat
  3. XM_005273165.2XP_005273222.1  

    Conserved Domains (8) summary
    pfam08337
    Location:13251823
    Plexin_cytopl; Plexin cytoplasmic RasGAP domain
    cd11272
    Location:53567
    Sema_plexin_A2; The Sema domain, a protein interacting module, of Plexin A2
    smart00630
    Location:65498
    Sema; semaphorin domain
    cd00603
    Location:11581233
    IPT_PCSR; IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the ...
    cd01179
    Location:9691052
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:873968
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01181
    Location:10561156
    IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    pfam01437
    Location:670717
    PSI; Plexin repeat

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 

    Range
    209467937..209690032
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000133.1 

    Range
    178869811..179092243
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)