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    RETN resistin [ Homo sapiens (human) ]

    Gene ID: 56729, updated on 28-Aug-2016
    Official Symbol
    RETNprovided by HGNC
    Official Full Name
    resistinprovided by HGNC
    Primary source
    HGNC:HGNC:20389
    See related
    Ensembl:ENSG00000104918 HPRD:05714; MIM:605565; Vega:OTTHUMG00000182503
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ADSF; RSTN; XCP1; FIZZ3; RETN1
    Summary
    This gene belongs to the family defined by the mouse resistin-like genes. The characteristic feature of this family is the C-terminal stretch of 10 cys residues with identical spacing. The mouse homolog of this protein is secreted by adipocytes, and may be the hormone potentially linking obesity to type II diabetes. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2010]
    Orthologs
    Location:
    19p13.2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 19 NC_000019.10 (7669086..7670454)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (7733972..7735340)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene syntaxin binding protein 2 Neighboring gene ribosomal protein S27a pseudogene 19 Neighboring gene mast cell expressed membrane protein 1 Neighboring gene trafficking protein particle complex 5

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Associated conditions

    Description Tests
    Diabetes mellitus type 2
    MedGen: C0011860 OMIM: 125853 GeneReviews: Not available
    Compare labs

    NHGRI GWAS Catalog

    Description
    Common quantitative trait locus downstream of RETN gene identified by genome-wide association study is associated with risk of type 2 diabetes mellitus in Han Chinese: a Mendelian randomization effect.
    NHGRI GWA Catalog
    Genome-wide association analysis identifies TYW3/CRYZ and NDST4 loci associated with circulating resistin levels.
    NHGRI GWA Catalog
    Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 upregulates the expression of resistin (RETN) in peptide-treated PBMCs PubMed

    Go to the HIV-1, Human Interaction Database

    • Adipogenesis, organism-specific biosystem (from WikiPathways)
      Adipogenesis, organism-specific biosystemThe different classess of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compo...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC126603, MGC126609

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    hormone activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    aging IEA
    Inferred from Electronic Annotation
    more info
     
    biological_process ND
    No biological Data available
    more info
     
    fat cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of feeding behavior IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of collagen metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of progesterone secretion IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of smooth muscle cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of smooth muscle cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
     
    response to insulin IEA
    Inferred from Electronic Annotation
    more info
     
    response to mechanical stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    resistin
    Names
    C/EBP-epsilon regulated myeloid-specific secreted cysteine-rich protein precursor 1
    adipose tissue-specific secretory factor
    c/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein
    cysteine-rich secreted protein A12-alpha-like 2
    cysteine-rich secreted protein FIZZ3
    found in inflammatory zone 3
    resistin delta2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_023447.1 RefSeqGene

      Range
      5001..6369
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001193374.1NP_001180303.1  resistin precursor

      See identical proteins and their annotated locations for NP_001180303.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks a segment in the 5' UTR, as compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AY207314
      Consensus CDS
      CCDS12182.1
      UniProtKB/Swiss-Prot
      Q9HD89
      Conserved Domains (1) summary
      pfam06954
      Location:20106
      Resistin; Resistin
    2. NM_020415.3NP_065148.1  resistin precursor

      See identical proteins and their annotated locations for NP_065148.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) is the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AF205952, BC069302
      Consensus CDS
      CCDS12182.1
      UniProtKB/Swiss-Prot
      Q9HD89
      Related
      ENSP00000221515, OTTHUMP00000269453, ENST00000221515, OTTHUMT00000461731
      Conserved Domains (1) summary
      pfam06954
      Location:20106
      Resistin; Resistin

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p7 Primary Assembly

      Range
      7669086..7670454
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018930.2 Alternate CHM1_1.1

      Range
      7733708..7735063
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)