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LCP1 lymphocyte cytosolic protein 1 (L-plastin) [ Homo sapiens (human) ]

Gene ID: 3936, updated on 18-Jan-2015
Official Symbol
LCP1provided by HGNC
Official Full Name
lymphocyte cytosolic protein 1 (L-plastin)provided by HGNC
Primary source
HGNC:HGNC:6528
Locus tag
RP11-139H14.1
See related
Ensembl:ENSG00000136167; HPRD:01082; MIM:153430; Vega:OTTHUMG00000016864
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LPL; CP64; PLS2; LC64P; HEL-S-37; L-PLASTIN
Summary
Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). However, L-plastin has been found in many types of malignant human cells of non-hemopoietic origin suggesting that its expression is induced accompanying tumorigenesis in solid tissues. [provided by RefSeq, Jul 2008]
Orthologs
See LCP1 in MapViewer
Location:
13q14.3
Exon count:
17
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 13 NC_000013.11 (46125923..46182324, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (46700058..46756459, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene zinc finger CCCH-type containing 13 Neighboring gene CPB2 antisense RNA 1 Neighboring gene carboxypeptidase B2 (plasma) Neighboring gene leucine rich repeat containing 63 Neighboring gene RNA, 7SK small nuclear pseudogene 5 Neighboring gene family with sequence similarity 206, member B, pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Association between liver-specific gene polymorphisms and their expression levels with nonalcoholic fatty liver disease.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of T-plastin and downregulates the expression of L-plastin in T-cell lines PubMed
Envelope surface glycoprotein gp160, precursor env Plasmin cleaves HIV-1 gp160 precisely at the C-terminal arginine residue 510 of gp120, yielding the mature gp120 and gp41 proteins PubMed
retropepsin gag-pol A number of focal adhesion plaque proteins are specifically cleaved by HIV-1 protease, including fimbrin, focal adhesion plaque kinase (FAK), talin, and, to a lesser extent, filamin, spectrin and fibronectin PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ25423, FLJ26114, FLJ39956, DKFZp781A23186

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin binding NAS
Non-traceable Author Statement
more info
PubMed 
actin filament binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
calcium ion binding NAS
Non-traceable Author Statement
more info
PubMed 
identical protein binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
T cell activation involved in immune response IDA
Inferred from Direct Assay
more info
PubMed 
actin filament bundle assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
organ regeneration IEA
Inferred from Electronic Annotation
more info
 
protein kinase A signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of intracellular protein transport IDA
Inferred from Direct Assay
more info
PubMed 
NOT wound healing, spreading of cells IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
actin cytoskeleton IDA
Inferred from Direct Assay
more info
 
actin filament IMP
Inferred from Mutant Phenotype
more info
PubMed 
actin filament bundle IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
 
cytoplasm NAS
Non-traceable Author Statement
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular vesicular exosome IDA
Inferred from Direct Assay
more info
PubMed 
filopodium IMP
Inferred from Mutant Phenotype
more info
PubMed 
focal adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
phagocytic cup IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 
ruffle IMP
Inferred from Mutant Phenotype
more info
PubMed 
ruffle membrane IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with stress fiber IMP
Inferred from Mutant Phenotype
more info
PubMed 
Preferred Names
plastin-2
Names
plastin-2
LCP-1
plastin 2
epididymis secretory protein Li 37
Lymphocyte cytosolic protein-1 (plasmin)
bA139H14.1 (lymphocyte cytosolic protein 1 (L-plastin))
L-plastin (Lymphocyte cytosolic protein 1) (LCP-1) (LC64P)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002298.4NP_002289.2  plastin-2

    See proteins identical to NP_002289.2

    Status: REVIEWED

    Source sequence(s)
    AY960627, BC007673, BF893502, DA820090, DB156931, J02923
    Consensus CDS
    CCDS9403.1
    UniProtKB/TrEMBL
    A0A024RDT4
    UniProtKB/Swiss-Prot
    P13796
    Related
    ENSP00000315757, ENST00000323076
    Conserved Domains (5) summary
    smart00033
    Location:398501
    CH; Calponin homology domain
    COG5069
    Location:16620
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00014
    Location:121236
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00051
    Location:1379
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00307
    Location:518624
    CH; Calponin homology (CH) domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000013.11 

    Range
    46125923..46182324
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005266374.1XP_005266431.1  

    See proteins identical to XP_005266431.1

    UniProtKB/TrEMBL
    A0A024RDT4
    UniProtKB/Swiss-Prot
    P13796
    Conserved Domains (5) summary
    smart00033
    Location:398501
    CH; Calponin homology domain
    COG5069
    Location:16620
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00014
    Location:121236
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00051
    Location:1379
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00307
    Location:518624
    CH; Calponin homology (CH) domain

Alternate CHM1_1.1

Genomic

  1. NC_018924.2 

    Range
    46669191..46725269
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000145.1 

    Range
    27497877..27554218
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)