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    CBLB Cbl proto-oncogene B [ Homo sapiens (human) ]

    Gene ID: 868, updated on 27-Aug-2016
    Official Symbol
    CBLBprovided by HGNC
    Official Full Name
    Cbl proto-oncogene Bprovided by HGNC
    Primary source
    HGNC:HGNC:1542
    See related
    Ensembl:ENSG00000114423 HPRD:05136; MIM:604491; Vega:OTTHUMG00000150654
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Cbl-b; RNF56; Nbla00127
    Orthologs
    Location:
    3q13.11
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 3 NC_000003.12 (105655461..105869552, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (105374306..105589354, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374023 Neighboring gene activated leukocyte cell adhesion molecule Neighboring gene uncharacterized LOC107986109 Neighboring gene uncharacterized LOC105374024 Neighboring gene uncharacterized LOC105374026

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 downregulates the expression of Cbl proto-oncogene B, E3 ubiquitin protein ligase (CBLB) in human B cells PubMed

    Go to the HIV-1, Human Interaction Database

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Antigen activates B Cell Receptor (BCR) leading to generation of second messengers, organism-specific biosystem (from REACTOME)
      Antigen activates B Cell Receptor (BCR) leading to generation of second messengers, organism-specific biosystemMature B cells express IgM and IgD immunoglobulins which are complexed with Ig-alpha (CD79A, MB-1) and Ig-beta (CD79B, B29) to form the B cell receptor (BCR) (Fu et al. 1974, Fu et al. 1975, Kunkel e...
    • Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem (from REACTOME)
      Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystemIntracellular foreign or aberrant host proteins are cleaved into peptide fragments of a precise size, such that they can be loaded on to class I MHC molecules and presented externally to cytotoxic T ...
    • B Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      B Cell Receptor Signaling Pathway, organism-specific biosystemThe B cell receptor includes membrane ?? heavy chain molecules bound to a light chain and an Ig alpha (CD79A)/Ig beta (CD79B) heterodimer. Activation of the B cell receptor involves phosphorylation o...
    • Bacterial invasion of epithelial cells, organism-specific biosystem (from KEGG)
      Bacterial invasion of epithelial cells, organism-specific biosystemMany pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-ph...
    • Bacterial invasion of epithelial cells, conserved biosystem (from KEGG)
      Bacterial invasion of epithelial cells, conserved biosystemMany pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-ph...
    • CD40/CD40L signaling, organism-specific biosystem (from Pathway Interaction Database)
      CD40/CD40L signaling, organism-specific biosystem
      CD40/CD40L signaling
    • Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem (from Pathway Interaction Database)
      Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem
      Calcineurin-regulated NFAT-dependent transcription in lymphocytes
    • Chronic myeloid leukemia, organism-specific biosystem (from KEGG)
      Chronic myeloid leukemia, organism-specific biosystemChronic myelogenous leukemia (CML) originates in a pluripotent hematopoetic stem cell of the bone marrow and is characterized by greatly increased numbers of granulocytes in the blood. Myeloid and ot...
    • Chronic myeloid leukemia, conserved biosystem (from KEGG)
      Chronic myeloid leukemia, conserved biosystemChronic myelogenous leukemia (CML) originates in a pluripotent hematopoetic stem cell of the bone marrow and is characterized by greatly increased numbers of granulocytes in the blood. Myeloid and ot...
    • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
      Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
    • EGFR1 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      EGFR1 Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
    • Endocytosis, organism-specific biosystem (from KEGG)
      Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Endocytosis, conserved biosystem (from KEGG)
      Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • ErbB signaling pathway, organism-specific biosystem (from KEGG)
      ErbB signaling pathway, organism-specific biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
    • ErbB signaling pathway, conserved biosystem (from KEGG)
      ErbB signaling pathway, conserved biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
    • Fc-epsilon receptor I signaling in mast cells, organism-specific biosystem (from Pathway Interaction Database)
      Fc-epsilon receptor I signaling in mast cells, organism-specific biosystem
      Fc-epsilon receptor I signaling in mast cells
    • IL-7 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-7 Signaling Pathway, organism-specific biosystemInterleukin-7 belongs to a family of cytokines, which includes IL-2, IL-4, IL-9, IL-15 and IL-21. It signals through a receptor complex consisting of IL-7 receptor alpha chain (IL7RA) and a common ga...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Insulin Signaling, organism-specific biosystem (from WikiPathways)
      Insulin Signaling, organism-specific biosystemInsulin signaling influences energy metabolism as well as growth. The presence of insulin signals the fed state, and this signal is passed via the AKT branch, which leads to the uptake of glucose fro...
    • Insulin signaling pathway, organism-specific biosystem (from KEGG)
      Insulin signaling pathway, organism-specific biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
    • Insulin signaling pathway, conserved biosystem (from KEGG)
      Insulin signaling pathway, conserved biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
    • Internalization of ErbB1, organism-specific biosystem (from Pathway Interaction Database)
      Internalization of ErbB1, organism-specific biosystem
      Internalization of ErbB1
    • Kit Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Kit Receptor Signaling Pathway, organism-specific biosystemKit is a receptor protein tyrosine kinase, which is a receptor for stem cell factor or kit ligand. Signaling through Kit is important for formation of red cells, lymphocytes, mast cells and platelets...
    • Measles, organism-specific biosystem (from KEGG)
      Measles, organism-specific biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
    • Measles, conserved biosystem (from KEGG)
      Measles, conserved biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Proteoglycans in cancer, organism-specific biosystem (from KEGG)
      Proteoglycans in cancer, organism-specific biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
    • Proteoglycans in cancer, conserved biosystem (from KEGG)
      Proteoglycans in cancer, conserved biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
    • Signaling by the B Cell Receptor (BCR), organism-specific biosystem (from REACTOME)
      Signaling by the B Cell Receptor (BCR), organism-specific biosystemMature B cells express IgM and IgD immunoglobulins which are complexed at the plasma membrane with Ig-alpha (CD79A, MB-1) and Ig-beta (CD79B, B29) to form the B cell receptor (BCR) (Fu et al. 1974, F...
    • T cell receptor signaling pathway, organism-specific biosystem (from KEGG)
      T cell receptor signaling pathway, organism-specific biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
    • T cell receptor signaling pathway, conserved biosystem (from KEGG)
      T cell receptor signaling pathway, conserved biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
    • TCR Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TCR Signaling Pathway, organism-specific biosystemThe T-cell antigen receptor (TCR) complex is composed of a ligand-binding subunit, the ? and ? chains, and a signaling subunit, namely the CD3?, ? and ? chains and the TCR? chain. This complex partic...
    • Ubiquitin mediated proteolysis, organism-specific biosystem (from KEGG)
      Ubiquitin mediated proteolysis, organism-specific biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
    • Ubiquitin mediated proteolysis, conserved biosystem (from KEGG)
      Ubiquitin mediated proteolysis, conserved biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ36865, FLJ41152, DKFZp779A0729, DKFZp779F1443, DKFZp686J10223

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    phosphotyrosine binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    signal transducer activity IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin-protein transferase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    ubiquitin-protein transferase activity TAS
    Traceable Author Statement
    more info
     
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    NLS-bearing protein import into nucleus TAS
    Traceable Author Statement
    more info
    PubMed 
    cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    protein polyubiquitination TAS
    Traceable Author Statement
    more info
     
    regulation of signaling IEA
    Inferred from Electronic Annotation
    more info
     
    response to gravity IEA
    Inferred from Electronic Annotation
    more info
     
    response to hormone IEA
    Inferred from Electronic Annotation
    more info
     
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    membrane raft IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    E3 ubiquitin-protein ligase CBL-B
    Names
    Cas-Br-M (murine) ecotropic retroviral transforming sequence b
    Cbl proto-oncogene B, E3 ubiquitin protein ligase
    Cbl proto-oncogene, E3 ubiquitin protein ligase B
    RING finger protein 56
    SH3-binding protein CBL-B
    casitas B-lineage lymphoma proto-oncogene b
    signal transduction protein CBL-B

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001321786.1NP_001308715.1  E3 ubiquitin-protein ligase CBL-B isoform a

      Status: VALIDATED

      Source sequence(s)
      AC016138, AC112485, AC126185
      Conserved Domains (5) summary
      pfam02262
      Location:70196
      Cbl_N; CBL proto-oncogene N-terminal domain 1
      cd09920
      Location:276372
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      pfam02761
      Location:199282
      Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
      cd00162
      Location:401443
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd14392
      Location:959999
      UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    2. NM_001321788.1NP_001308717.1  E3 ubiquitin-protein ligase CBL-B isoform b

      Status: VALIDATED

      Description
      Transcript Variant: Variants 2 and 3 encode the same isoform (b).
      Source sequence(s)
      AC016138, AC112485, AC126185
      UniProtKB/Swiss-Prot
      Q13191
      Conserved Domains (5) summary
      cd09920
      Location:248344
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      cd00162
      Location:373415
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd14392
      Location:931971
      UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
      pfam02262
      Location:44167
      Cbl_N; CBL proto-oncogene N-terminal domain 1
      pfam02761
      Location:171254
      Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    3. NM_001321789.1NP_001308718.1  E3 ubiquitin-protein ligase CBL-B isoform c

      Status: VALIDATED

      Source sequence(s)
      AC016138, AC112485, AC126185
      Conserved Domains (5) summary
      cd09920
      Location:276372
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      cd00162
      Location:401443
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd14392
      Location:910950
      UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
      pfam02262
      Location:72195
      Cbl_N; CBL proto-oncogene N-terminal domain 1
      pfam02761
      Location:199282
      Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    4. NM_001321790.1NP_001308719.1  E3 ubiquitin-protein ligase CBL-B isoform d

      Status: VALIDATED

      Source sequence(s)
      AC016138, AI221219, AK302533, AK316276
      UniProtKB/TrEMBL
      B4DYP3, B7ZAG1
      Conserved Domains (5) summary
      cd09920
      Location:270366
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      cd00162
      Location:395437
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd14392
      Location:909949
      UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
      pfam02262
      Location:66189
      Cbl_N; CBL proto-oncogene N-terminal domain 1
      pfam02761
      Location:193276
      Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    5. NM_001321791.1NP_001308720.1  E3 ubiquitin-protein ligase CBL-B isoform e

      Status: VALIDATED

      Description
      Transcript Variant: Variants 6 and 7 encode the same isoform (e).
      Source sequence(s)
      AC016138, AC112485, AC126185
      Conserved Domains (5) summary
      pfam02262
      Location:42168
      Cbl_N; CBL proto-oncogene N-terminal domain 1
      cd09920
      Location:248344
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      pfam02761
      Location:171254
      Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
      cd00162
      Location:373415
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd14392
      Location:887927
      UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    6. NM_001321793.1NP_001308722.1  E3 ubiquitin-protein ligase CBL-B isoform e

      Status: VALIDATED

      Description
      Transcript Variant: Variants 6 and 7 encode the same isoform (e).
      Source sequence(s)
      AC016138, AC112485, AC126185
      Conserved Domains (5) summary
      pfam02262
      Location:42168
      Cbl_N; CBL proto-oncogene N-terminal domain 1
      cd09920
      Location:248344
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      pfam02761
      Location:171254
      Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
      cd00162
      Location:373415
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd14392
      Location:887927
      UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    7. NM_001321794.1NP_001308723.1  E3 ubiquitin-protein ligase CBL-B isoform f

      Status: VALIDATED

      Description
      Transcript Variant: Variants 8 and 9 encode the same isoform (f), which is the same length as isoform g but differs in the amino acid sequence.
      Source sequence(s)
      AC016138, AC112485, AC126185
      Conserved Domains (5) summary
      cd09920
      Location:248344
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      cd00162
      Location:373415
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd14392
      Location:882922
      UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
      pfam02262
      Location:44167
      Cbl_N; CBL proto-oncogene N-terminal domain 1
      pfam02761
      Location:171254
      Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    8. NM_001321795.1NP_001308724.1  E3 ubiquitin-protein ligase CBL-B isoform f

      Status: VALIDATED

      Description
      Transcript Variant: Variants 8 and 9 encode the same isoform (f), which is the same length as isoform g but differs in the amino acid sequence.
      Source sequence(s)
      AC016138, AC112485, AC126185
      Conserved Domains (5) summary
      cd09920
      Location:248344
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      cd00162
      Location:373415
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd14392
      Location:882922
      UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
      pfam02262
      Location:44167
      Cbl_N; CBL proto-oncogene N-terminal domain 1
      pfam02761
      Location:171254
      Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    9. NM_001321796.1NP_001308725.1  E3 ubiquitin-protein ligase CBL-B isoform g

      Status: VALIDATED

      Description
      Transcript Variant: Isoform g is the same length as isoform f but differs in the amino acid sequence.
      Source sequence(s)
      AC016138, AC112485
      Conserved Domains (5) summary
      cd09920
      Location:199295
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      cd00162
      Location:324366
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd14392
      Location:882922
      UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
      pfam02262
      Location:44140
      Cbl_N; CBL proto-oncogene N-terminal domain 1
      pfam02761
      Location:123205
      Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    10. NM_001321797.1NP_001308726.1  E3 ubiquitin-protein ligase CBL-B isoform h

      Status: VALIDATED

      Description
      Transcript Variant: Variants 11 and 12 encode the same isoform (h), which is the same length as isoform i but differs in the amino acid sequence.
      Source sequence(s)
      AC016138, AC112485, AC126185
      Conserved Domains (5) summary
      cd09920
      Location:248344
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      cd00162
      Location:373415
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd14392
      Location:838878
      UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
      pfam02262
      Location:44167
      Cbl_N; CBL proto-oncogene N-terminal domain 1
      pfam02761
      Location:171254
      Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    11. NM_001321798.1NP_001308727.1  E3 ubiquitin-protein ligase CBL-B isoform h

      Status: VALIDATED

      Description
      Transcript Variant: Variants 11 and 12 encode the same isoform (h), which is the same length as isoform i but differs in the amino acid sequence.
      Source sequence(s)
      AC016138, AC112485, AC126185
      Conserved Domains (5) summary
      cd09920
      Location:248344
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      cd00162
      Location:373415
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd14392
      Location:838878
      UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
      pfam02262
      Location:44167
      Cbl_N; CBL proto-oncogene N-terminal domain 1
      pfam02761
      Location:171254
      Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    12. NM_001321799.1NP_001308728.1  E3 ubiquitin-protein ligase CBL-B isoform i

      Status: VALIDATED

      Description
      Transcript Variant: Isoform i is the same length as isoform h but differs in the amino acid sequence.
      Source sequence(s)
      AC016138, AC112485
      Conserved Domains (5) summary
      cd09920
      Location:199295
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      cd00162
      Location:324366
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd14392
      Location:838878
      UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
      pfam02262
      Location:44140
      Cbl_N; CBL proto-oncogene N-terminal domain 1
      pfam02761
      Location:123205
      Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    13. NM_001321806.1NP_001308735.1  E3 ubiquitin-protein ligase CBL-B isoform j

      Status: VALIDATED

      Description
      Transcript Variant: Variants 14 and 15 encode the same isoform (j).
      Source sequence(s)
      AC016138, AC112485, AC126185
      Conserved Domains (3) summary
      cd09920
      Location:184
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      cd00162
      Location:113155
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd14392
      Location:671711
      UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    14. NM_001321807.1NP_001308736.1  E3 ubiquitin-protein ligase CBL-B isoform j

      Status: VALIDATED

      Description
      Transcript Variant: Variants 14 and 15 encode the same isoform (j).
      Source sequence(s)
      AC016138, AC112485, AC126185
      Conserved Domains (3) summary
      cd09920
      Location:184
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      cd00162
      Location:113155
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd14392
      Location:671711
      UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    15. NM_001321808.1NP_001308737.1  E3 ubiquitin-protein ligase CBL-B isoform k

      Status: VALIDATED

      Source sequence(s)
      AC016138, AC112485, AC126185
      Conserved Domains (3) summary
      cd09920
      Location:184
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      cd00162
      Location:113155
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd14392
      Location:627667
      UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    16. NM_001321811.1NP_001308740.1  E3 ubiquitin-protein ligase CBL-B isoform l

      Status: VALIDATED

      Description
      Transcript Variant: Variants 17 and 18 encode the same isoform (l).
      Source sequence(s)
      AC016138, AC112485, AC126185
      Conserved Domains (3) summary
      cd09920
      Location:184
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      cd00162
      Location:113155
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd14392
      Location:622662
      UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    17. NM_001321813.1NP_001308742.1  E3 ubiquitin-protein ligase CBL-B isoform l

      Status: VALIDATED

      Description
      Transcript Variant: Variants 17 and 18 encode the same isoform (l).
      Source sequence(s)
      AC016138, AC112485, AC126185
      Conserved Domains (3) summary
      cd09920
      Location:184
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      cd00162
      Location:113155
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd14392
      Location:622662
      UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    18. NM_001321816.1NP_001308745.1  E3 ubiquitin-protein ligase CBL-B isoform m

      Status: VALIDATED

      Source sequence(s)
      AC016138, AC112485, AC126185
      Conserved Domains (3) summary
      cd09920
      Location:184
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      cd00162
      Location:113155
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd14392
      Location:578618
      UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    19. NM_001321820.1NP_001308749.1  E3 ubiquitin-protein ligase CBL-B isoform n

      Status: VALIDATED

      Source sequence(s)
      AC016138, AC112485, AC126185
      Conserved Domains (1) summary
      cd14392
      Location:491531
      UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    20. NM_001321822.1NP_001308751.1  E3 ubiquitin-protein ligase CBL-B isoform o

      Status: VALIDATED

      Source sequence(s)
      AC016138, AC112485, AC126185
      Conserved Domains (1) summary
      cd14392
      Location:488528
      UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    21. NM_170662.4NP_733762.2  E3 ubiquitin-protein ligase CBL-B isoform b

      See identical proteins and their annotated locations for NP_733762.2

      Status: VALIDATED

      Description
      Transcript Variant: Variants 2 and 3 encode the same isoform (b).
      Source sequence(s)
      AC016138, AI221219, AK094184, BC032851, BC065915, U26710
      Consensus CDS
      CCDS2948.1
      UniProtKB/Swiss-Prot
      Q13191
      UniProtKB/TrEMBL
      B3KSS7
      Related
      ENSP00000264122, OTTHUMP00000198145, ENST00000264122, OTTHUMT00000319417
      Conserved Domains (5) summary
      cd09920
      Location:248344
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      cd00162
      Location:373415
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd14392
      Location:931971
      UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
      pfam02262
      Location:44167
      Cbl_N; CBL proto-oncogene N-terminal domain 1
      pfam02761
      Location:171254
      Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

    RNA

    1. NR_135806.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC016138, AC112485, AC126185
    2. NR_135807.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC016138, AC112485, AC126185
    3. NR_135808.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC016138, AC112485, AC126185
    4. NR_135809.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC016138, AC112485, AC126185
    5. NR_135810.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC016138, AC112485, AC126185
    6. NR_135811.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC016138, AC112485, AC126185
    7. NR_135812.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC016138, AC112485, AC126185

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p7 Primary Assembly

      Range
      105655461..105869552 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011513257.1XP_011511559.1  

      See identical proteins and their annotated locations for XP_011511559.1

      UniProtKB/Swiss-Prot
      Q13191
      Conserved Domains (5) summary
      cd09920
      Location:248344
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      cd00162
      Location:373415
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd14392
      Location:931971
      UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
      pfam02262
      Location:44167
      Cbl_N; CBL proto-oncogene N-terminal domain 1
      pfam02761
      Location:171254
      Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    2. XM_017007395.1XP_016862884.1  

    3. XM_017007398.1XP_016862887.1  

    4. XM_017007399.1XP_016862888.1  

      Conserved Domains (5) summary
      cd09920
      Location:199295
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      cd00162
      Location:324366
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd14392
      Location:882922
      UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
      pfam02262
      Location:44140
      Cbl_N; CBL proto-oncogene N-terminal domain 1
      pfam02761
      Location:123205
      Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    5. XM_017007400.1XP_016862889.1  

    6. XM_017007397.1XP_016862886.1  

    7. XM_017007396.1XP_016862885.1  

    8. XM_011513259.2XP_011511561.2  

      Related
      ENSP00000384938, OTTHUMP00000198147, ENST00000405772, OTTHUMT00000319419

    RNA

    1. XR_001740339.1 RNA Sequence

    2. XR_001740338.1 RNA Sequence

    Alternate CHM1_1.1

    Genomic

    1. NC_018914.2 Alternate CHM1_1.1

      Range
      105337423..105551745 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)