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Runx3 runt related transcription factor 3 [ Mus musculus (house mouse) ]

Gene ID: 12399, updated on 19-Jul-2014
Official Symbol
Runx3provided by MGI
Official Full Name
runt related transcription factor 3provided by MGI
Primary source
MGI:102672
Locus tag
RP23-167O21.1
See related
Ensembl:ENSMUSG00000070691; Vega:OTTMUSG00000031877
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AML2; Cbfa3; Pebp2a3
See Runx3 in Epigenomics, MapViewer
Location:
4 D3; 4 67.19 cM
Exon count:
7
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 4 NC_000070.6 (135120645..135177990)

Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene SYF2 homolog, RNA splicing factor (S. cerevisiae) Neighboring gene uncharacterized LOC102632474 Neighboring gene serine-repeat antigen protein-like Neighboring gene chloride intracellular channel 4 (mitochondrial) Neighboring gene uncharacterized LOC102632783

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
 
sequence-specific DNA binding RNA polymerase II transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific DNA binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell maturation IGI
Inferred from Genetic Interaction
more info
PubMed 
chondrocyte differentiation IGI
Inferred from Genetic Interaction
more info
 
hair follicle morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
interferon-gamma production IDA
Inferred from Direct Assay
more info
 
mRNA transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of extrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
nuclear chromatin IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
runt-related transcription factor 3
Names
runt-related transcription factor 3
CBF-alpha-3
PEA2-alpha C
PEBP2-alpha C
oncogene AML-2
core binding factor alpha 3
runt domain, alpha subunit 3
transcription factor AML2/CBFA3
acute myeloid leukemia 2 protein
core-binding factor subunit alpha-3
SL3-3 enhancer factor 1 alpha C subunit
SL3/AKV core-binding factor alpha C subunit
polyomavirus enhancer-binding protein 2 alpha C subunit

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019732.2NP_062706.2  runt-related transcription factor 3

    See proteins identical to NP_062706.2

    Status: VALIDATED

    Source sequence(s)
    AK155436, AL731718
    Consensus CDS
    CCDS18782.1
    UniProtKB/TrEMBL
    Q3U1Q3
    Related
    ENSMUSP00000050353, OTTMUSP00000042120, ENSMUST00000056977, OTTMUST00000079034
    Conserved Domains (2) summary
    pfam00853
    Location:68201
    Blast Score: 724
    Runt; Runt domain
    pfam08504
    Location:325423
    Blast Score: 352
    RunxI; Runx inhibition domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000070.6 

    Range
    135120645..135177990
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006538506.1XP_006538569.1  

    See proteins identical to XP_006538569.1

    Conserved Domains (2) summary
    pfam00853
    Location:177
    Blast Score: 432
    Runt; Runt domain
    pfam08504
    Location:201299
    Blast Score: 334
    RunxI; Runx inhibition domain

Reference GRCm38.p2 NOD/MrkTac

Genomic

  1. NT_187024.1 

    Range
    98816..156156
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006537058.1XP_006537121.1  

    See proteins identical to XP_006537121.1

    Conserved Domains (2) summary
    pfam00853
    Location:177
    Blast Score: 432
    Runt; Runt domain
    pfam08504
    Location:201299
    Blast Score: 334
    RunxI; Runx inhibition domain

Alternate Mm_Celera

Genomic

  1. AC_000026.1 

    Range
    133305992..133363404
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)