Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    GCN5 histone acetyltransferase GCN5 [ Saccharomyces cerevisiae S288c ]

    Gene ID: 853167, updated on 12-Jul-2016
    Gene symbol
    GCN5
    Gene description
    histone acetyltransferase GCN5
    Primary source
    SGD:S000003484
    Locus tag
    YGR252W
    Gene type
    protein coding
    RNA name
    histone acetyltransferase GCN5
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288c (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    AAS104; ADA4; KAT2; SWI9
    See GCN5 in Map Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (996869..998188)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene Nop19p Neighboring gene proteasome core particle subunit alpha 5 Neighboring gene phosphopyruvate hydratase ENO1

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Homology

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    H3 histone acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    H3 histone acetyltransferase activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    H3 histone acetyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    N-acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    histone acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    lysine-acetylated histone binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription coactivator activity TAS
    Traceable Author Statement
    more info
    PubMed 
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity, transferring acyl groups IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    chromatin modification IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromatin remodeling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    covalent chromatin modification IEA
    Inferred from Electronic Annotation
    more info
     
    histone acetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone acetylation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    histone acetylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription elongation from RNA polymerase II promoter IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription elongation from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Ada2/Gcn5/Ada3 transcription activator complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    SAGA complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    SLIK (SAGA-like) complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    Names
    histone acetyltransferase GCN5
    NP_011768.1
    • Catalytic subunit of ADA and SAGA histone acetyltransferase complexes; modifies N-terminal lysines on histones H2B and H3; acetylates Rsc4p, a subunit of the RSC chromatin-remodeling complex, altering replication stress tolerance; relocalizes to the cytosol in response to hypoxia; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; greater involvement in repression of RNAPII-dependent transcription than in activation

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      996869..998188
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181381.1NP_011768.1  histone acetyltransferase GCN5 [Saccharomyces cerevisiae S288c]

      See identical proteins and their annotated locations for NP_011768.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q03330
      Conserved Domains (3) summary
      cd05509
      Location:331431
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      cd04301
      Location:148202
      NAT_SF; N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate
      COG5076
      Location:77439
      COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]