Display Settings:

Format

Send to:

Choose Destination

Cybb cytochrome b-245, beta polypeptide [ Mus musculus (house mouse) ]

Gene ID: 13058, updated on 10-Dec-2014
Official Symbol
Cybbprovided by MGI
Official Full Name
cytochrome b-245, beta polypeptideprovided by MGI
Primary source
MGI:MGI:88574
Locus tag
RP23-243O4.1
See related
Ensembl:ENSMUSG00000015340; Vega:OTTMUSG00000016894
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cgd; Cyd; Nox2; C88302; gp91-1; gp91phox; CGD91-phox
Summary
This gene encodes the heavy chain component of a heterodimeric transmembrane ion transporter composed of both a heavy and a light chain. This transporter mediates the transfer of electrons from nicotinamide adenine dinucleotide phosphate (NADPH) to oxygen to generate superoxide. This reaction is important in the innate immune response to pathogens. However, increased activity of the encoded protein also leads to the generation of reactive oxygen species that result in oxidative stress and can cause tissue damage. Conversely, loss of function of the related gene in human causes chronic granulomatous disease. Alternative splicing results in multiple transcript variants, although the full-length nature of some of these variants has not been determined. [provided by RefSeq, May 2013]
See Cybb in Epigenomics, MapViewer
Location:
X A1.1; X
Exon count:
14
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) X NC_000086.7 (9435254..9487765, complement)

Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene Kell blood group precursor (McLeod phenotype) homolog Neighboring gene predicted gene 4055 Neighboring gene predicted gene 14501 Neighboring gene predicted gene, 33784 Neighboring gene predicted gene 5132 Neighboring gene dynein light chain Tctex-type 3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
N-ethylmaleimide reductase activity IEA
Inferred from Electronic Annotation
more info
 
NADPH:sulfur oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
contributes_to electron carrier activity ISO
Inferred from Sequence Orthology
more info
 
epoxyqueuosine reductase activity IEA
Inferred from Electronic Annotation
more info
 
flavin adenine dinucleotide binding ISO
Inferred from Sequence Orthology
more info
 
heme binding ISO
Inferred from Sequence Orthology
more info
 
malolactic enzyme activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
reduced coenzyme F420 dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
 
sulfur oxygenase reductase activity IEA
Inferred from Electronic Annotation
more info
 
superoxide-generating NADPH oxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to superoxide-generating NADPH oxidase activity ISO
Inferred from Sequence Orthology
more info
 
voltage-gated ion channel activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
hydrogen peroxide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
innate immune response ISO
Inferred from Sequence Orthology
more info
 
ion transport IEA
Inferred from Electronic Annotation
more info
 
oxidation-reduction process IDA
Inferred from Direct Assay
more info
PubMed 
oxidation-reduction process ISO
Inferred from Sequence Orthology
more info
 
regulation of ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
respiratory burst ISO
Inferred from Sequence Orthology
more info
 
response to drug ISO
Inferred from Sequence Orthology
more info
 
superoxide anion generation ISO
Inferred from Sequence Orthology
more info
 
superoxide metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
superoxide metabolic process ISO
Inferred from Sequence Orthology
more info
 
transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
NADPH oxidase complex IDA
Inferred from Direct Assay
more info
PubMed 
NADPH oxidase complex ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
dendrite ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
intracellular ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
rough endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
cytochrome b-245 heavy chain
Names
cytochrome b-245 heavy chain
NADPH oxidase 2
p22 phagocyte B-cytochrome
cytochrome b558 subunit beta
neutrophil cytochrome b 91 kDa polypeptide
heme-binding membrane glycoprotein gp91phox

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007807.5NP_031833.3  cytochrome b-245 heavy chain

    See proteins identical to NP_031833.3

    Status: REVIEWED

    Source sequence(s)
    AK152257, AL671864, BY194282
    Consensus CDS
    CCDS30010.1
    UniProtKB/TrEMBL
    Q3U6G0
    UniProtKB/Swiss-Prot
    Q61093
    Related
    ENSMUSP00000015484, OTTMUSP00000018354, ENSMUST00000015484, OTTMUST00000040996
    Conserved Domains (2) summary
    cd06186
    Location:297570
    NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
    pfam01794
    Location:63220
    Ferric_reduct; Ferric reductase like transmembrane component

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000086.7 

    Range
    9435254..9487765
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527565.1XP_006527628.1  

    See proteins identical to XP_006527628.1

    UniProtKB/TrEMBL
    Q3U6G0
    UniProtKB/Swiss-Prot
    Q61093
    Conserved Domains (2) summary
    cd06186
    Location:297570
    NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
    pfam01794
    Location:63220
    Ferric_reduct; Ferric reductase like transmembrane component

Alternate Mm_Celera

Genomic

  1. AC_000042.1 

    Range
    7154876..7188991
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)