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Lrp8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor [ Mus musculus (house mouse) ]

Gene ID: 16975, updated on 19-Jul-2014
Official Symbol
Lrp8provided by MGI
Official Full Name
low density lipoprotein receptor-related protein 8, apolipoprotein e receptorprovided by MGI
Primary source
MGI:1340044
Locus tag
RP23-184N11.8
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lr8b; ApoER2; AA921429; AI848122; 4932703M08Rik
See Lrp8 in Epigenomics, MapViewer
Location:
4 C7; 4
Exon count:
21
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 4 NC_000070.6 (107802259..107876840)

Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102634068 Neighboring gene translocase of outer mitochondrial membrane 22 pseudogene Neighboring gene RIKEN cDNA 4933424M12 gene Neighboring gene low density lipoprotein receptor-related protein 8, apolipoprotein e receptor, opposite strand 2 Neighboring gene RIKEN cDNA 0610037L13 gene Neighboring gene mago-nashi homolog, proliferation-associated (Drosophila)

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
apolipoprotein binding IDA
Inferred from Direct Assay
more info
PubMed 
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
calcium-dependent protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
glycoprotein binding IPI
Inferred from Physical Interaction
more info
PubMed 
high-density lipoprotein particle binding ISO
Inferred from Sequence Orthology
more info
 
kinesin binding ISO
Inferred from Sequence Orthology
more info
 
low-density lipoprotein receptor activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
reelin receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
very-low-density lipoprotein particle receptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
ammon gyrus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
endocytosis ISO
Inferred from Sequence Orthology
more info
 
hippocampus development IGI
Inferred from Genetic Interaction
more info
PubMed 
layer formation in cerebral cortex IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of CREB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
 
positive regulation of dendrite development IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of dendritic spine morphogenesis IMP
Inferred from Mutant Phenotype
more info
 
positive regulation of peptidyl-tyrosine phosphorylation IMP
Inferred from Mutant Phenotype
more info
 
positive regulation of protein kinase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of protein tyrosine kinase activity IMP
Inferred from Mutant Phenotype
more info
 
receptor-mediated endocytosis ISO
Inferred from Sequence Orthology
more info
 
receptor-mediated endocytosis TAS
Traceable Author Statement
more info
PubMed 
reelin-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
axon ISO
Inferred from Sequence Orthology
more info
 
caveola ISO
Inferred from Sequence Orthology
more info
 
dendrite ISO
Inferred from Sequence Orthology
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
microtubule associated complex ISO
Inferred from Sequence Orthology
more info
 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
plasma membrane TAS
Traceable Author Statement
more info
PubMed 
postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
receptor complex ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
low-density lipoprotein receptor-related protein 8
Names
low-density lipoprotein receptor-related protein 8
apolipoprotein E receptor 2
low density lipoprotein receptor relative, 8 ligand binding repeats, brain

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080926.1NP_001074395.1  low-density lipoprotein receptor-related protein 8 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longer transcript and is protein-coding.
    Source sequence(s)
    AL611936, AL807828, CJ129380
    Consensus CDS
    CCDS51255.1
    UniProtKB/TrEMBL
    B1AXJ3
    Conserved Domains (5) summary
    smart00135
    Location:397438
    Blast Score: 154
    LY; Low-density lipoprotein-receptor YWTD domain
    cd00054
    Location:283316
    Blast Score: 98
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00112
    Location:4175
    Blast Score: 146
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00058
    Location:459499
    Blast Score: 173
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam14670
    Location:247281
    Blast Score: 118
    FXa_inhibition; Coagulation Factor Xa inhibitory site

RNA

  1. NR_033496.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) includes an alternate internal exon and an alternate splice site in the central region, and lacks a segment in the 3' region, compared to variant 2. This variant is represented as non-coding because the use of the supported translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL611936, AL807828, CJ129380

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000070.6 

    Range
    107802259..107876840
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000026.1 

    Range
    106150293..106225723
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_053073.3: Suppressed sequence

    Description
    NM_053073.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.