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    HOXA10 homeobox A10 [ Homo sapiens (human) ]

    Gene ID: 3206, updated on 22-Sep-2016
    Official Symbol
    HOXA10provided by HGNC
    Official Full Name
    homeobox A10provided by HGNC
    Primary source
    HGNC:HGNC:5100
    See related
    Ensembl:ENSG00000253293 HPRD:00845; MIM:142957; Vega:OTTHUMG00000023436
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PL; HOX1; HOX1H; HOX1.8
    Summary
    In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor that may regulate gene expression, morphogenesis, and differentiation. More specifically, it may function in fertility, embryo viability, and regulation of hematopoietic lineage commitment. Alternatively spliced transcript variants have been described. Read-through transcription also exists between this gene and the downstream homeobox A9 (HOXA9) gene. [provided by RefSeq, Mar 2011]
    Orthologs
    Location:
    7p15.2
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 7 NC_000007.14 (27170591..27180261, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (27210210..27219880, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene HOXA10-HOXA9 readthrough Neighboring gene homeobox A9 Neighboring gene HOXA10 antisense RNA Neighboring gene microRNA 196b Neighboring gene homeobox A11 Neighboring gene HOXA11 antisense RNA

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genome-wide association scan of dental caries in the permanent dentition.
    NHGRI GWA Catalog
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Readthrough HOXA10-HOXA9

    Readthrough gene: HOXA10-HOXA9, Included gene: HOXA9

    Homology

    Clone Names

    • MGC12859

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    anterior/posterior pattern specification IEA
    Inferred from Electronic Annotation
    more info
     
    embryonic limb morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    male gonad development IEA
    Inferred from Electronic Annotation
    more info
     
    multicellular organism development TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    proximal/distal pattern formation IEA
    Inferred from Electronic Annotation
    more info
     
    single fertilization IEA
    Inferred from Electronic Annotation
    more info
     
    skeletal system development IEA
    Inferred from Electronic Annotation
    more info
     
    spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    uterus development IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor complex IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    homeobox protein Hox-A10
    Names
    homeo box A10
    homeobox protein 1H
    homeobox protein HOXA10
    homeobox protein Hox-1.8
    homeobox protein Hox-1H

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018951.3NP_061824.3  homeobox protein Hox-A10

      See identical proteins and their annotated locations for NP_061824.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein.
      Source sequence(s)
      BC013971, BF196481, BX439708
      Consensus CDS
      CCDS5410.2
      UniProtKB/Swiss-Prot
      P31260
      Related
      ENSP00000283921, OTTHUMP00000217273, ENST00000283921, OTTHUMT00000358724
      Conserved Domains (1) summary
      pfam00046
      Location:339392
      Homeobox; Homeobox domain

    RNA

    1. NR_037939.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate 5' exon, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
      Source sequence(s)
      AL710880, BC013971, BC071843, BF196481, DB267919

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p7 Primary Assembly

      Range
      27170591..27180261 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018918.2 Alternate CHM1_1.1

      Range
      27209927..27219601 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_153715.3: Suppressed sequence

      Description
      NM_153715.3: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
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