Display Settings:

Format

Send to:

Choose Destination

RASD1 RAS, dexamethasone-induced 1 [ Homo sapiens (human) ]

Gene ID: 51655, updated on 11-Sep-2014
Official Symbol
RASD1provided by HGNC
Official Full Name
RAS, dexamethasone-induced 1provided by HGNC
Primary source
HGNC:HGNC:15828
See related
Ensembl:ENSG00000108551; HPRD:08958; MIM:605550; Vega:OTTHUMG00000059292
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AGS1; DEXRAS1; MGC:26290
Summary
This gene encodes a member of the Ras superfamily of small GTPases and is induced by dexamethasone. The encoded protein is an activator of G-protein signaling and acts as a direct nucleotide exchange factor for Gi-Go proteins. This protein interacts with the neuronal nitric oxide adaptor protein CAPON, and a nuclear adaptor protein FE65, which interacts with the Alzheimer's disease amyloid precursor protein. This gene may play a role in dexamethasone-induced alterations in cell morphology, growth and cell-extracellular matrix interactions. Epigenetic inactivation of this gene is closely correlated with resistance to dexamethasone in multiple myeloma cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2011]
See RASD1 in Epigenomics, MapViewer
Location:
17p11.2
Exon count:
2
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 17 NC_000017.11 (17494437..17496395, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (17397751..17399709, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene TSEN15 tRNA splicing endonuclease subunit pseudogene 1 Neighboring gene mediator complex subunit 9 Neighboring gene phosphatidylethanolamine N-methyltransferase Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene 43 Neighboring gene retinoic acid induced 1 Neighboring gene Smith-Magenis syndrome chromosome region, candidate 5 (non-protein coding)

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.
NHGRI GWA Catalog
Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants.
NHGRI GWA Catalog
  • Circadian entrainment, organism-specific biosystem (from KEGG)
    Circadian entrainment, organism-specific biosystemCircadian entrainment is a fundamental property by which the period of the internal biological clock is entrained by recurring exogenous signals, such that the organism's endocrine and behavioral rhy...
  • Circadian entrainment, conserved biosystem (from KEGG)
    Circadian entrainment, conserved biosystemCircadian entrainment is a fundamental property by which the period of the internal biological clock is entrained by recurring exogenous signals, such that the organism's endocrine and behavioral rhy...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding IEA
Inferred from Electronic Annotation
more info
 
GTPase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
G-protein coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
GTP catabolic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
nitric oxide mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
dexamethasone-induced Ras-related protein 1
Names
dexamethasone-induced Ras-related protein 1
ras-related protein
activator of G-protein signaling 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028074.1 

    Range
    5001..6959
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001199989.1NP_001186918.1  dexamethasone-induced Ras-related protein 1 isoform 2

    See proteins identical to NP_001186918.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate splice site in the CDS that results in a frame-shift compared to variant 1. The resulting isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK294073, BC018041, BC042688
    Consensus CDS
    CCDS58519.1
    UniProtKB/Swiss-Prot
    Q9Y272
    Related
    ENSP00000463388, OTTHUMP00000259848, ENST00000579152, OTTHUMT00000442879
    Conserved Domains (1) summary
    cl17170
    Location:2595
    Blast Score: 422
    Ras_like_GTPase; Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases)
  2. NM_016084.4NP_057168.1  dexamethasone-induced Ras-related protein 1 isoform 1 proprotein

    See proteins identical to NP_057168.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK312796, BC018041, BC042688
    Consensus CDS
    CCDS11185.1
    UniProtKB/Swiss-Prot
    Q9Y272
    Related
    ENSP00000225688, OTTHUMP00000065541, ENST00000225688, OTTHUMT00000131668
    Conserved Domains (2) summary
    cd04143
    Location:25281
    Blast Score: 1172
    Rhes_like; Ras homolog enriched in striatum (Rhes) and activator of G-protein signaling 1 (Dexras1/AGS1)
    COG1100
    Location:21200
    Blast Score: 200
    COG1100; GTPase SAR1 and related small G proteins [General function prediction only]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000017.11 

    Range
    17494437..17496395
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000149.1 

    Range
    17150071..17152029
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018928.2 

    Range
    17406422..17408380
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)