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    Mstn myostatin [ Mus musculus (house mouse) ]

    Gene ID: 17700, updated on 25-Aug-2016
    Official Symbol
    Mstnprovided by MGI
    Official Full Name
    myostatinprovided by MGI
    Primary source
    MGI:MGI:95691
    See related
    Ensembl:ENSMUSG00000026100 Vega:OTTMUSG00000046890
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cmpt; Gdf8
    Summary
    This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein negatively regulates skeletal muscle cell proliferation and differentiation. Homozygous knockout mice for this gene exhibit increased muscle mass and bone density, and reduced adiposity. [provided by RefSeq, Jul 2016]
    Orthologs
    Location:
    1 C1.1; 1 26.99 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (53061640..53068079)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (53118507..53124923)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene 3-hydroxyisobutyryl-Coenzyme A hydrolase Neighboring gene heat shock protein 90, alpha (cytosolic), class A member 1 pseudogene Neighboring gene RIKEN cDNA 1700019D03 gene Neighboring gene RIKEN cDNA 1700019A02 gene Neighboring gene postmeiotic segregation increased 1 (S. cerevisiae)

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC124261, MGC124262, MGC124263

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    cytokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    growth factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    heparin binding IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    transforming growth factor beta receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    SMAD protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cell development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cellular response to dexamethasone stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    growth IEA
    Inferred from Electronic Annotation
    more info
     
    mitophagy in response to mitochondrial depolarization ISO
    Inferred from Sequence Orthology
    more info
     
    muscle cell cellular homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of insulin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of muscle hypertrophy ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of myoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein kinase B signaling ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of skeletal muscle tissue growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of skeletal muscle tissue growth ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of defense response to virus by host ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of pathway-restricted SMAD protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    skeletal muscle atrophy IMP
    Inferred from Mutant Phenotype
    more info
     
    transforming growth factor beta receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    xenophagy ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    growth/differentiation factor 8

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010834.3NP_034964.1  growth/differentiation factor 8 preproprotein

      See identical proteins and their annotated locations for NP_034964.1

      Status: REVIEWED

      Source sequence(s)
      AK132415, AK142222
      Consensus CDS
      CCDS14950.1
      UniProtKB/Swiss-Prot
      O08689
      UniProtKB/TrEMBL
      Q540E2
      Related
      ENSMUSP00000027269, OTTMUSP00000066957, ENSMUST00000027269, OTTMUST00000121584
      Conserved Domains (2) summary
      smart00204
      Location:282376
      TGFB; Transforming growth factor-beta (TGF-beta) family
      pfam00688
      Location:40250
      TGFb_propeptide; TGF-beta propeptide

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      53061640..53068079
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)