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Ghrl ghrelin [ Mus musculus (house mouse) ]

Gene ID: 58991, updated on 19-Apr-2015
Official Symbol
Ghrlprovided by MGI
Official Full Name
ghrelinprovided by MGI
Primary source
MGI:MGI:1930008
See related
Ensembl:ENSMUSG00000064177
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ghr; m46; MTLRP; MTLRPAP; 2210006E23Rik
Summary
This gene encodes a preproprotein that is cleaved to yield two peptides, ghrelin and obestatin. The hormone ghrelin plays a role in enhancing appetite and has numerous other biological functions that include stimulating the secretion of growth hormone (somatotropin) from the anterior pituitary gland. Obestatin is thought to be a hormone that functions in decreasing appetite. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2013]
Orthologs
See Ghrl in MapViewer
Location:
6 E3; 6 52.84 cM
Exon count:
6
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 6 NC_000072.6 (113716119..113727485, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (113666113..113669874, complement)

Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene interleukin-1 receptor-associated kinase 2 Neighboring gene TatD DNase domain containing 2 Neighboring gene microRNA 7042 Neighboring gene SEC13 homolog (S. cerevisiae) Neighboring gene ATPase, Ca++ transporting, plasma membrane 2 Neighboring gene predicted gene 15083

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
G-protein coupled receptor binding ISO
Inferred from Sequence Orthology
more info
 
ghrelin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
ghrelin receptor binding ISO
Inferred from Sequence Orthology
more info
 
growth hormone-releasing hormone activity IBA
Inferred from Biological aspect of Ancestor
more info
 
growth hormone-releasing hormone activity ISO
Inferred from Sequence Orthology
more info
 
hormone activity ISO
Inferred from Sequence Orthology
more info
 
hormone activity TAS
Traceable Author Statement
more info
PubMed 
protein tyrosine kinase activator activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
G-protein coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
actin polymerization or depolymerization ISO
Inferred from Sequence Orthology
more info
 
activation of MAPK activity ISO
Inferred from Sequence Orthology
more info
 
adult feeding behavior IDA
Inferred from Direct Assay
more info
PubMed 
decidualization ISO
Inferred from Sequence Orthology
more info
 
dendrite development IMP
Inferred from Mutant Phenotype
more info
PubMed 
dendrite development ISO
Inferred from Sequence Orthology
more info
 
gastric acid secretion IBA
Inferred from Biological aspect of Ancestor
more info
 
gastric acid secretion ISO
Inferred from Sequence Orthology
more info
 
hormone-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of circadian sleep/wake cycle, REM sleep ISO
Inferred from Sequence Orthology
more info
 
negative regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of energy homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
 
negative regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
negative regulation of insulin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of insulin secretion ISA
Inferred from Sequence Alignment
more info
PubMed 
negative regulation of interleukin-1 beta production ISO
Inferred from Sequence Orthology
more info
 
negative regulation of interleukin-6 biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of locomotion IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of tumor necrosis factor biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of appetite IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of appetite IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of appetite IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT positive regulation of appetite IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of circadian sleep/wake cycle, non-REM sleep ISO
Inferred from Sequence Orthology
more info
 
positive regulation of corticotropin secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cortisol secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of energy homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of growth hormone secretion IBA
Inferred from Biological aspect of Ancestor
more info
 
positive regulation of growth hormone secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
positive regulation of protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of response to food ISO
Inferred from Sequence Orthology
more info
 
positive regulation of synapse assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of synapse assembly ISO
Inferred from Sequence Orthology
more info
 
regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
regulation of excitatory postsynaptic membrane potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of response to food ISO
Inferred from Sequence Orthology
more info
 
response to estrogen ISO
Inferred from Sequence Orthology
more info
 
response to hormone ISO
Inferred from Sequence Orthology
more info
 
visual learning ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
axon ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region ISO
Inferred from Sequence Orthology
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
appetite-regulating hormone; uncharacterized protein LOC58991
Names
appetite-regulating hormone
growth hormone secretagogue
growth hormone-releasing peptide
motilin-related peptide
preproghrelin
proghrelin

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286404.1NP_001273333.1  appetite-regulating hormone isoform 2 preproprotein

    See identical proteins and their annotated locations for NP_001273333.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region compared to variant 1. This results in a shorter protein (isoform 2) compared to isoform 1 which includes both the ghrelin and obestatin ligands.
    Source sequence(s)
    AC117596
    UniProtKB/Swiss-Prot
    Q9EQX0
    Conserved Domains (2) summary
    pfam04643
    Location:55116
    Motilin_assoc; Motilin/ghrelin-associated peptide
    pfam04644
    Location:2450
    Motilin_ghrelin; Motilin/ghrelin
  2. NM_001286405.1NP_001273334.1  uncharacterized protein LOC58991 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001273334.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an exon in the 3' coding region resulting in a frameshift compared to variant 1. The encoded protein (isoform 3) is shorter than isoform 1 and has a distinct C-terminus. Proteolytic cleavage to produce ghrelin and a C-terminal peptide may occur but has yet to be demonstrated conclusively (PMID 15471962). This isoform lacks the obestatin ligand.
    Source sequence(s)
    AK008860, BC094911
    UniProtKB/TrEMBL
    Q811T4
    UniProtKB/Swiss-Prot
    Q9EQX0
    Conserved Domains (1) summary
    pfam04644
    Location:2451
    Motilin_ghrelin; Motilin/ghrelin
  3. NM_001286406.1NP_001273335.1  uncharacterized protein LOC58991 isoform 4 precursor

    See identical proteins and their annotated locations for NP_001273335.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks an in-frame exon in the 5' coding region compared to variant 1. The encoded protein (isoform 4) is shorter than isoform 1. This isoform includes the sequence of a truncated ghelin ligand and a complete obestatin ligand, but its proteolytic processing has yet to be determined.
    Source sequence(s)
    AB111891, AK008860
    UniProtKB/TrEMBL
    Q7TSD1
    UniProtKB/Swiss-Prot
    Q9EQX0
    Conserved Domains (1) summary
    pfam04643
    Location:2378
    Motilin_assoc; Motilin/ghrelin-associated peptide
  4. NM_021488.5NP_067463.2  appetite-regulating hormone isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_067463.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1) which includes both the ghrelin and obestatin ligands.
    Source sequence(s)
    AK008860, FJ355944
    Consensus CDS
    CCDS20432.1
    UniProtKB/TrEMBL
    A2RSS9
    UniProtKB/Swiss-Prot
    Q9EQX0
    Related
    ENSMUSP00000069567, ENSMUST00000064993
    Conserved Domains (2) summary
    pfam04643
    Location:56117
    Motilin_assoc; Motilin/ghrelin-associated peptide
    pfam04644
    Location:2451
    Motilin_ghrelin; Motilin/ghrelin

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000072.6 Reference GRCm38.p3 C57BL/6J

    Range
    113716119..113727485
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011241423.1XP_011239725.1  

    Conserved Domains (2) summary
    pfam04643
    Location:228289
    Motilin_assoc; Motilin/ghrelin-associated peptide
    pfam04644
    Location:197223
    Motilin_ghrelin; Motilin/ghrelin
  2. XM_011241422.1XP_011239724.1  

    Conserved Domains (2) summary
    pfam04643
    Location:229290
    Motilin_assoc; Motilin/ghrelin-associated peptide
    pfam04644
    Location:197224
    Motilin_ghrelin; Motilin/ghrelin
  3. XM_006506446.2XP_006506509.1  

    See identical proteins and their annotated locations for XP_006506509.1

    UniProtKB/TrEMBL
    A2RSS9
    UniProtKB/Swiss-Prot
    Q9EQX0
    Conserved Domains (2) summary
    pfam04643
    Location:56117
    Motilin_assoc; Motilin/ghrelin-associated peptide
    pfam04644
    Location:2451
    Motilin_ghrelin; Motilin/ghrelin
  4. XM_006506447.2XP_006506510.1  

    Conserved Domains (1) summary
    pfam04643
    Location:1254
    Motilin_assoc; Motilin/ghrelin-associated peptide

Alternate Mm_Celera

Genomic

  1. AC_000028.1 Alternate Mm_Celera

    Range
    115541628..115545422
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)