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Bace1 beta-site APP cleaving enzyme 1 [ Mus musculus (house mouse) ]

Gene ID: 23821, updated on 20-Apr-2015
Official Symbol
Bace1provided by MGI
Official Full Name
beta-site APP cleaving enzyme 1provided by MGI
Primary source
MGI:MGI:1346542
See related
Ensembl:ENSMUSG00000032086; Vega:OTTMUSG00000034962
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C76936
Orthologs
See Bace1 in MapViewer
Location:
9; 9 A5.2
Exon count:
10
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 9 NC_000075.6 (45838529..45862484)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (45646612..45670567)

Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene centrosomal protein 164 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene ring finger protein 214 Neighboring gene proprotein convertase subtilisin/kexin type 7 Neighboring gene transgelin

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Alzheimer's disease, organism-specific biosystem (from KEGG)
    Alzheimer's disease, organism-specific biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
  • Alzheimer's disease, conserved biosystem (from KEGG)
    Alzheimer's disease, conserved biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
aspartic-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
aspartic-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
beta-amyloid binding IBA
Inferred from Biological aspect of Ancestor
more info
 
beta-amyloid binding ISO
Inferred from Sequence Orthology
more info
 
endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
peptidase activity ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
beta-amyloid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
beta-amyloid metabolic process ISO
Inferred from Sequence Orthology
more info
 
membrane protein ectodomain proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
 
membrane protein ectodomain proteolysis ISO
Inferred from Sequence Orthology
more info
 
protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
proteolysis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
 
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
axon IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
endosome ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
late endosome ISO
Inferred from Sequence Orthology
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
multivesicular body ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
trans-Golgi network ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
beta-secretase 1
Names
beta-secretase 1
APP beta-secretase
ASP2
asp 2
aspartyl protease 2
beta-site amyloid precursor protein cleaving enzyme 1
memapsin-2
membrane-associated aspartic protease 2
NP_001139419.1
NP_035922.4

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145947.1NP_001139419.1  beta-secretase 1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001139419.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. This results in a shorter protein (isoform 2) compared to isoform 1.
    Source sequence(s)
    AK082317, BC048189, BY724111
    Consensus CDS
    CCDS52784.1
    UniProtKB/Swiss-Prot
    P56818
    UniProtKB/TrEMBL
    Q8C4F4
    Related
    ENSMUSP00000077249, OTTMUSP00000048511, ENSMUST00000078111, OTTMUST00000088891
    Conserved Domains (2) summary
    cd05473
    Location:72403
    beta_secretase_like; Beta-secretase, aspartic-acid protease important in the pathogenesis of Alzheimer's disease
    pfam00026
    Location:75382
    Asp; Eukaryotic aspartyl protease
  2. NM_011792.5NP_035922.4  beta-secretase 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_035922.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK082317, BC048189, BY724111
    Consensus CDS
    CCDS23135.1
    UniProtKB/Swiss-Prot
    P56818
    UniProtKB/TrEMBL
    Q8C4F4
    Conserved Domains (2) summary
    cd05473
    Location:72437
    beta_secretase_like; Beta-secretase, aspartic-acid protease important in the pathogenesis of Alzheimer's disease
    pfam00026
    Location:75416
    Asp; Eukaryotic aspartyl protease

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000075.6 Reference GRCm38.p3 C57BL/6J

    Range
    45838529..45862484
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011242513.1XP_011240815.1  

    See identical proteins and their annotated locations for XP_011240815.1

    Conserved Domains (1) summary
    cl11403
    Location:1203
    pepsin_retropepsin_like; Cellular and retroviral pepsin-like aspartate proteases
  2. XM_011242512.1XP_011240814.1  

    Conserved Domains (2) summary
    cd05473
    Location:22372
    beta_secretase_like; Beta-secretase, aspartic-acid protease important in the pathogenesis of Alzheimer's disease
    pfam00026
    Location:22351
    Asp; Eukaryotic aspartyl protease

Alternate Mm_Celera

Genomic

  1. AC_000031.1 Alternate Mm_Celera

    Range
    43121304..43145259
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)