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    Grem1 gremlin 1 [ Mus musculus (house mouse) ]

    Gene ID: 23892, updated on 30-Jun-2015
    Official Symbol
    Grem1provided by MGI
    Official Full Name
    gremlin 1provided by MGI
    Primary source
    MGI:MGI:1344337
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ld; Drm; Grem; Cktsf1b1
    Orthologs
    See Grem1 in Epigenomics, MapViewer
    Location:
    2 E4; 2 57.43 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) 2 NC_000068.7 (113748674..113758788, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (113588832..113598805, complement)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene formin 1 Neighboring gene predicted gene 13964 Neighboring gene RIKEN cDNA 4930533B01 gene Neighboring gene secretogranin V Neighboring gene Rho GTPase activating protein 11A

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Spontaneous (1) 
    • Targeted (3)  1 citation
    • Radiation induced (1) 

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    cytokine activity IEA
    Inferred from Electronic Annotation
    more info
     
    heparan sulfate proteoglycan binding TAS
    Traceable Author Statement
    more info
    PubMed 
    receptor agonist activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transmembrane receptor protein tyrosine kinase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    vascular endothelial growth factor receptor 2 binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    activation of transmembrane receptor protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    angiogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    branching involved in ureteric bud morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cell migration involved in sprouting angiogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    cell-cell signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    collagen fibril organization ISO
    Inferred from Sequence Orthology
    more info
     
    determination of dorsal identity ISO
    Inferred from Sequence Orthology
    more info
     
    embryonic limb morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    endothelial cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    limb development ISO
    Inferred from Sequence Orthology
    more info
     
    mesenchymal to epithelial transition involved in metanephros morphogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of BMP signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of BMP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of bone mineralization ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of bone mineralization involved in bone maturation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of bone remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of bone trabecula formation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of branching involved in ureteric bud morphogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of chondrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of leukocyte chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of monocyte chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of osteoblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of osteoclast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of pathway-restricted SMAD protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    organ morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of NF-kappaB import into nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of NF-kappaB transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of branching involved in ureteric bud morphogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cardiac muscle cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of peptidyl-tyrosine autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of receptor activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    positive regulation of receptor internalization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of telomerase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    proximal/distal pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of focal adhesion assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT regulation of stress-activated MAPK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    signal transduction IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    NOT signal transduction by p53 class mediator IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    ureteric bud formation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    colocalizes_with cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    gremlin-1
    Names
    cysteine knot superfamily 1, BMP antagonist 1
    down-regulated in Mos-transformed cells protein
    down-regulated in v-mos-transformed cells

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011824.4NP_035954.1  gremlin-1 precursor

      See identical proteins and their annotated locations for NP_035954.1

      Status: VALIDATED

      Source sequence(s)
      AL772405
      Consensus CDS
      CCDS16560.1
      UniProtKB/Swiss-Prot
      O70326
      UniProtKB/TrEMBL
      Q3TNY7
      Conserved Domains (1) summary
      pfam03045
      Location:68184
      DAN; DAN domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p3 C57BL/6J

      Range
      113748674..113758788
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006499444.2XP_006499507.1  

      See identical proteins and their annotated locations for XP_006499507.1

      UniProtKB/TrEMBL
      Q3UY25
      Conserved Domains (1) summary
      pfam03045
      Location:124240
      DAN; DAN domain

    Alternate Mm_Celera

    Genomic

    1. AC_000024.1 Alternate Mm_Celera

      Range
      114881929..114891879
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)