Display Settings:

Format

Send to:

Choose Destination
    • Showing Current items.

    ZPR1 ZPR1 zinc finger [ Homo sapiens (human) ]

    Gene ID: 8882, updated on 1-Jul-2015
    Official Symbol
    ZPR1provided by HGNC
    Official Full Name
    ZPR1 zinc fingerprovided by HGNC
    Primary source
    HGNC:HGNC:13051
    See related
    HPRD:04877; MIM:603901
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZNF259
    Orthologs
    See ZPR1 in Epigenomics, MapViewer
    Location:
    11q23.3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 11 NC_000011.10 (116778560..116788023, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (116649276..116658739, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene BUD13 homolog Neighboring gene uncharacterized LOC105369514 Neighboring gene apolipoprotein A-V Neighboring gene apolipoprotein A-IV

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium.
    NHGRI GWA Catalog
    Amerindian-specific regions under positive selection harbour new lipid variants in Latinos.
    NHGRI GWA Catalog
    An atlas of genetic influences on human blood metabolites.
    NHGRI GWA Catalog
    Biological, clinical and population relevance of 95 loci for blood lipids.
    NHGRI GWA Catalog
    Common variants at 30 loci contribute to polygenic dyslipidemia.
    NHGRI GWA Catalog
    Discovery and refinement of loci associated with lipid levels.
    NHGRI GWA Catalog
    Eight genetic loci associated with variation in lipoprotein-associated phospholipase A2 mass and activity and coronary heart disease: meta-analysis of genome-wide association studies from five community-based studies.
    NHGRI GWA Catalog
    Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia.
    NHGRI GWA Catalog
    Genetic variants influencing circulating lipid levels and risk of coronary artery disease.
    NHGRI GWA Catalog
    Genome-wide association study identifies common variants associated with circulating vitamin E levels.
    NHGRI GWA Catalog
    Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia.
    NHGRI GWA Catalog
    Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations.
    NHGRI GWA Catalog
    Genome-wide association study identifies three common variants associated with serologic response to vitamin E supplementation in men.
    NHGRI GWA Catalog
    Genome-wide association study of Lp-PLA(2) activity and mass in the Framingham Heart Study.
    NHGRI GWA Catalog
    Genome-wide characterization of shared and distinct genetic components that influence blood lipid levels in ethnically diverse human populations.
    NHGRI GWA Catalog
    Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits.
    NHGRI GWA Catalog
    Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci.
    NHGRI GWA Catalog
    Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.
    NHGRI GWA Catalog
    Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits.
    NHGRI GWA Catalog
    Meta-analysis of genome-wide association studies for circulating phylloquinone concentrations.
    NHGRI GWA Catalog
    Newly identified loci that influence lipid concentrations and risk of coronary artery disease.
    NHGRI GWA Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    NHGRI GWA Catalog
    Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis.
    NHGRI GWA Catalog
    Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants.
    NHGRI GWA Catalog
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC110983

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    receptor tyrosine kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    translation initiation factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    Cajal body organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Cajal body organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    DNA endoreduplication ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    RNA splicing IEA
    Inferred from Electronic Annotation
    more info
     
    apoptotic process involved in development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    axon development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    axon development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cell proliferation TAS
    Traceable Author Statement
    more info
    PubMed 
    cellular response to epidermal growth factor stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    inner cell mass cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of motor neuron apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of RNA splicing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of growth ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of protein import into nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription involved in G1/S transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    pre-mRNA catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of myelination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    spinal cord development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    trophectodermal cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    Cajal body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Gemini of coiled bodies IDA
    Inferred from Direct Assay
    more info
    PubMed 
    SMN complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    axon IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    axon ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    growth cone ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    neuronal cell body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    perikaryon ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    zinc finger protein ZPR1
    Names
    zinc finger protein 259

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003904.3NP_003895.1  zinc finger protein ZPR1

      See identical proteins and their annotated locations for NP_003895.1

      Status: PROVISIONAL

      Source sequence(s)
      BC017349
      Consensus CDS
      CCDS8375.1
      UniProtKB/Swiss-Prot
      O75312
      Conserved Domains (1) summary
      pfam03367
      Location:48207
      zf-ZPR1; ZPR1 zinc-finger domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p2 Primary Assembly

      Range
      116778560..116788023
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018922.2 Alternate CHM1_1.1

      Range
      116533917..116543379
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)