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Icos inducible T cell co-stimulator [ Mus musculus (house mouse) ]

Gene ID: 54167, updated on 30-Jun-2014
Official Symbol
Icosprovided by MGI
Official Full Name
inducible T cell co-stimulatorprovided by MGI
Primary source
MGI:1858745
Locus tag
CH29-120A16.4
See related
Ensembl:ENSMUSG00000026009; Vega:OTTMUSG00000002307
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
H4; CCLP; AILIM; CRP-1; Ly115
See Icos in Epigenomics, MapViewer
Location:
1 C2; 1 30.6 cM
Exon count :
11
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 1 NC_000067.6 (60960773..61000322)

Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102638045 Neighboring gene dynein light chain LC8-type 1 pseudogene Neighboring gene ribosomal protein L17, pseudogene 1 Neighboring gene uncharacterized LOC102638129

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
    Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
  • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
    Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
  • Costimulation by the CD28 family, organism-specific biosystem (from REACTOME)
    Costimulation by the CD28 family, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Intestinal immune network for IgA production, organism-specific biosystem (from KEGG)
    Intestinal immune network for IgA production, organism-specific biosystemThe intestine is the largest lymphoid tissue in the body. One striking feature of intestinal immunity is its ability to generate great amounts of noninflammatory immunoglobulin A (IgA) antibodies tha...
  • Intestinal immune network for IgA production, conserved biosystem (from KEGG)
    Intestinal immune network for IgA production, conserved biosystemThe intestine is the largest lymphoid tissue in the body. One striking feature of intestinal immunity is its ability to generate great amounts of noninflammatory immunoglobulin A (IgA) antibodies tha...
  • Primary immunodeficiency, organism-specific biosystem (from KEGG)
    Primary immunodeficiency, organism-specific biosystemPrimary immunodeficiencies (PIs) are a heterogeneous group of disorders, which affect cellular and humoral immunity or non-specific host defense mechanisms mediated by complement proteins, and cells ...
  • Primary immunodeficiency, conserved biosystem (from KEGG)
    Primary immunodeficiency, conserved biosystemPrimary immunodeficiencies (PIs) are a heterogeneous group of disorders, which affect cellular and humoral immunity or non-specific host defense mechanisms mediated by complement proteins, and cells ...
  • T cell receptor signaling pathway, organism-specific biosystem (from KEGG)
    T cell receptor signaling pathway, organism-specific biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
  • T cell receptor signaling pathway, conserved biosystem (from KEGG)
    T cell receptor signaling pathway, conserved biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
T cell costimulation ISO
Inferred from Sequence Orthology
more info
 
T cell tolerance induction ISO
Inferred from Sequence Orthology
more info
 
single organismal cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
inducible T-cell costimulator
Names
inducible T-cell costimulator
CD28-related protein 1
CD28 and CTLA-4-like protein
inducible T-cell co-stimulator
activation-inducible lymphocyte immunomediatory molecule

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017480.2NP_059508.2  inducible T-cell costimulator precursor

    See proteins identical to NP_059508.2

    Status: VALIDATED

    Source sequence(s)
    AI451625, AK030827, BB850356, BC034852
    Consensus CDS
    CCDS14994.1
    UniProtKB/TrEMBL
    Q3V3X2
    UniProtKB/TrEMBL
    Q5SUZ7
    UniProtKB/Swiss-Prot
    Q9WVS0
    Related
    ENSMUSP00000099891, OTTMUSP00000002206, ENSMUST00000102827, OTTMUST00000004595
    Conserved Domains (1) summary
    cl11960
    Location:30127
    Blast Score: 91
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000067.6 

    Range
    60960773..61000322
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006496138.1XP_006496201.1  

    See proteins identical to XP_006496201.1

    UniProtKB/TrEMBL
    Q5SUZ7
    UniProtKB/Swiss-Prot
    Q9WVS0
    Conserved Domains (1) summary
    cl11960
    Location:30127
    Blast Score: 91
    Ig; Immunoglobulin domain
  2. XM_006496139.1XP_006496202.1  

    See proteins identical to XP_006496202.1

    UniProtKB/TrEMBL
    Q5SUZ7
    UniProtKB/Swiss-Prot
    Q9WVS0
    Conserved Domains (1) summary
    cl11960
    Location:30127
    Blast Score: 91
    Ig; Immunoglobulin domain
  3. XM_006496140.1XP_006496203.1  

    Conserved Domains (1) summary
    cl11960
    Location:198
    Blast Score: 90
    Ig; Immunoglobulin domain

Reference GRCm38.p2 NOD/MrkTac

Genomic

  1. NT_187019.1 

    Range
    340206..377933
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006536905.1XP_006536968.1  

    See proteins identical to XP_006536968.1

    UniProtKB/TrEMBL
    A2A6A7
    UniProtKB/Swiss-Prot
    Q9WVS0
    Conserved Domains (1) summary
    cl11960
    Location:30127
    Blast Score: 91
    Ig; Immunoglobulin domain
  2. XM_006536906.1XP_006536969.1  

    See proteins identical to XP_006536969.1

    UniProtKB/TrEMBL
    A2A6A7
    UniProtKB/Swiss-Prot
    Q9WVS0
    Conserved Domains (1) summary
    cl11960
    Location:30127
    Blast Score: 91
    Ig; Immunoglobulin domain

Alternate Mm_Celera

Genomic

  1. AC_000023.1 

    Range
    61493037..61515464
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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