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    MET MET proto-oncogene, receptor tyrosine kinase [ Homo sapiens (human) ]

    Gene ID: 4233, updated on 26-Jul-2015
    Official Symbol
    METprovided by HGNC
    Official Full Name
    MET proto-oncogene, receptor tyrosine kinaseprovided by HGNC
    Primary source
    HGNC:HGNC:7029
    See related
    Ensembl:ENSG00000105976; HPRD:01280; MIM:164860; Vega:OTTHUMG00000023299
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HGFR; AUTS9; RCCP2; c-Met; DFNB97
    Summary
    The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    7q31
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 7 NC_000007.14 (116672405..116798386)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (116312406..116438440)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene caveolin 1, caveolae protein, 22kDa Neighboring gene long intergenic non-protein coding RNA 1510 Neighboring gene KIAA1468 pseudogene Neighboring gene capping protein (actin filament) muscle Z-line, alpha 2 Neighboring gene uncharacterized LOC105375465 Neighboring gene RNA, 5S ribosomal pseudogene 239

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Associated conditions

    Description Tests
    Hepatocellular carcinoma
    MedGen: C2239176 OMIM: 114550 GeneReviews: Not available
    Compare labs
    Renal cell carcinoma, papillary, 1
    MedGen: C0007134 OMIM: 605074 GeneReviews: Not available
    Compare labs

    Copy number response

    Description
    Copy number response
    Haploinsufficency

    No evidence available (Last evaluated (2012-09-06)

    ClinGen Genome Curation Page
    Triplosensitivity

    No evidence available (Last evaluated (2012-09-06)

    ClinGen Genome Curation Page

    NHGRI GWAS Catalog

    Description
    Discovery and refinement of loci associated with lipid levels.
    NHGRI GWA Catalog
    Genetic determinants of P wave duration and PR segment.
    NHGRI GWA Catalog
    Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis.
    NHGRI GWA Catalog
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    • Direct p53 effectors, organism-specific biosystem (from Pathway Interaction Database)
      Direct p53 effectors, organism-specific biosystem
      Direct p53 effectors
    • Endocytosis, organism-specific biosystem (from KEGG)
      Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Endocytosis, conserved biosystem (from KEGG)
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    • Epithelial cell signaling in Helicobacter pylori infection, organism-specific biosystem (from KEGG)
      Epithelial cell signaling in Helicobacter pylori infection, organism-specific biosystemTwo major virulence factors of H. pylori are the vacuolating cytotoxin (VacA) and the cag type-IV secretion system (T4SS) and its translocated effector protein, cytotoxin-associated antigen A (CagA)....
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      FGF signaling pathway, organism-specific biosystem
      FGF signaling pathway
    • Focal Adhesion, organism-specific biosystem (from WikiPathways)
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    • Signaling events mediated by TCPTP, organism-specific biosystem (from Pathway Interaction Database)
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    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    hepatocyte growth factor-activated receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein tyrosine kinase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    protein tyrosine kinase activity TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    activation of MAPK activity IEA
    Inferred from Electronic Annotation
    more info
     
    adult behavior IEA
    Inferred from Electronic Annotation
    more info
     
    axon guidance TAS
    Traceable Author Statement
    more info
     
    brain development IEA
    Inferred from Electronic Annotation
    more info
     
    branching morphogenesis of an epithelial tube IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell proliferation TAS
    Traceable Author Statement
    more info
    PubMed 
    cell surface receptor signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    endothelial cell morphogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glucose homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    hepatocyte growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    liver development IEA
    Inferred from Electronic Annotation
    more info
     
    muscle cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    myoblast proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    myotube differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of hydrogen peroxide-mediated programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    peptidyl-tyrosine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    peptidyl-tyrosine phosphorylation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    peptidyl-tyrosine phosphorylation TAS
    Traceable Author Statement
    more info
     
    placenta development IEA
    Inferred from Electronic Annotation
    more info
     
    positive chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of endothelial cell chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of glucose transport IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein autophosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling IEA
    Inferred from Electronic Annotation
    more info
     
    semaphorin-plexin signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    skeletal muscle tissue development IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    basal plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    hepatocyte growth factor receptor
    Names
    HGF receptor
    HGF/SF receptor
    SF receptor
    met proto-oncogene tyrosine kinase
    proto-oncogene c-Met
    scatter factor receptor
    soluble MET variant 12
    tyrosine-protein kinase Met
    NP_000236.2
    NP_001120972.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008996.1 RefSeqGene

      Range
      5001..130982
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_662

    mRNA and Protein(s)

    1. NM_000245.2NP_000236.2  hepatocyte growth factor receptor isoform b precursor

      See identical proteins and their annotated locations for NP_000236.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the end of an exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AA278232, AI630755, BX648782, X54559
      Consensus CDS
      CCDS43636.1
      UniProtKB/TrEMBL
      A0A024R759
      UniProtKB/Swiss-Prot
      P08581
      Related
      ENSP00000380860, OTTHUMP00000069168, ENST00000397752, OTTHUMT00000141947
      Conserved Domains (8) summary
      cd11278
      Location:25516
      Sema_MET; The Sema domain, a protein interacting module, of MET (also called hepatocyte growth factor receptor, HGFR)
      cd00603
      Location:839932
      IPT_PCSR; IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the ...
      cd01179
      Location:657740
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01180
      Location:563656
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01181
      Location:742837
      IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      pfam01437
      Location:519562
      PSI; Plexin repeat
      pfam07714
      Location:10781337
      Pkinase_Tyr; Protein tyrosine kinase
      cd05058
      Location:10821343
      PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron
    2. NM_001127500.1NP_001120972.1  hepatocyte growth factor receptor isoform a precursor

      See identical proteins and their annotated locations for NP_001120972.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AC002543, AI630755, BC130420, BX648782, J02958
      Consensus CDS
      CCDS47689.1
      UniProtKB/TrEMBL
      A0A024R728
      UniProtKB/Swiss-Prot
      P08581
      Conserved Domains (8) summary
      cd11278
      Location:25516
      Sema_MET; The Sema domain, a protein interacting module, of MET (also called hepatocyte growth factor receptor, HGFR)
      cd00603
      Location:857950
      IPT_PCSR; IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the ...
      cd01179
      Location:657740
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01180
      Location:563656
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      pfam01437
      Location:519562
      PSI; Plexin repeat
      pfam07714
      Location:10961355
      Pkinase_Tyr; Protein tyrosine kinase
      cl15674
      Location:742855
      IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
      cd05058
      Location:11001361
      PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p2 Primary Assembly

      Range
      116672405..116798386
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011516223.1XP_011514525.1  

      Conserved Domains (8) summary
      cd11278
      Location:44535
      Sema_MET; The Sema domain, a protein interacting module, of MET (also called hepatocyte growth factor receptor, HGFR)
      cd00603
      Location:858951
      IPT_PCSR; IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the ...
      cd01179
      Location:676759
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01180
      Location:582675
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01181
      Location:761856
      IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      pfam01437
      Location:538581
      PSI; Plexin repeat
      pfam07714
      Location:10971356
      Pkinase_Tyr; Protein tyrosine kinase
      cd05058
      Location:11011362
      PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron
    2. XM_006715991.2XP_006716054.1  

      See identical proteins and their annotated locations for XP_006716054.1

      UniProtKB/TrEMBL
      B4DLF5
      Conserved Domains (8) summary
      cd00603
      Location:409502
      IPT_PCSR; IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the ...
      cd01179
      Location:227310
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01180
      Location:133226
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      pfam01437
      Location:89132
      PSI; Plexin repeat
      pfam07714
      Location:648907
      Pkinase_Tyr; Protein tyrosine kinase
      cl15674
      Location:312407
      IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
      cd05058
      Location:652913
      PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron
      cl15693
      Location:186
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins
    3. XM_006715990.2XP_006716053.1  

      See identical proteins and their annotated locations for XP_006716053.1

      UniProtKB/TrEMBL
      B4DLF5
      Conserved Domains (8) summary
      cd00603
      Location:409502
      IPT_PCSR; IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the ...
      cd01179
      Location:227310
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01180
      Location:133226
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      pfam01437
      Location:89132
      PSI; Plexin repeat
      pfam07714
      Location:648907
      Pkinase_Tyr; Protein tyrosine kinase
      cl15674
      Location:312407
      IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
      cd05058
      Location:652913
      PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron
      cl15693
      Location:186
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

    Alternate CHM1_1.1

    Genomic

    1. NC_018918.2 Alternate CHM1_1.1

      Range
      116246063..116372044
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)