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Bcr breakpoint cluster region [ Mus musculus (house mouse) ]

Gene ID: 110279, updated on 26-Aug-2014
Official Symbol
Bcrprovided by MGI
Official Full Name
breakpoint cluster regionprovided by MGI
Primary source
MGI:88141
See related
Ensembl:ENSMUSG00000009681
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AI561783; AI853148; mKIAA3017; 5133400C09Rik
Location:
10 B5.3-C1; 10 38.49 cM
Exon count:
25
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 10 NC_000076.6 (75060560..75184923)

Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene rhabdoid tumor deletion region gene 1 Neighboring gene guanine nucleotide binding protein, alpha z subunit Neighboring gene uncharacterized LOC102638446 Neighboring gene RAB36, member RAS oncogene family Neighboring gene uncharacterized LOC102638369 Neighboring gene sperm antigen with calponin homology and coiled-coil domains 1-like Neighboring gene adenosine A2a receptor

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
GTPase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
GTPase activator activity TAS
Traceable Author Statement
more info
PubMed 
Rac GTPase activator activity IGI
Inferred from Genetic Interaction
more info
PubMed 
Rho guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
actin cytoskeleton organization IGI
Inferred from Genetic Interaction
more info
PubMed 
brain development IGI
Inferred from Genetic Interaction
more info
PubMed 
inner ear morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of neutrophil degranulation IGI
Inferred from Genetic Interaction
more info
PubMed 
neuromuscular process controlling balance IGI
Inferred from Genetic Interaction
more info
PubMed 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
platelet-derived growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of Rac GTPase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of phagocytosis IGI
Inferred from Genetic Interaction
more info
PubMed 
protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
regulation of cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
PubMed 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
extracellular vesicular exosome ISO
Inferred from Sequence Orthology
more info
 
intracellular IEA
Inferred from Electronic Annotation
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
protein complex ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
breakpoint cluster region protein
Names
breakpoint cluster region protein
breakpoint cluster region homolog
NP_001074881.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081412.2NP_001074881.1  breakpoint cluster region protein

    See proteins identical to NP_001074881.1

    Status: VALIDATED

    Source sequence(s)
    AC160402, BC131682
    Consensus CDS
    CCDS35935.1
    UniProtKB/TrEMBL
    A2RRK7
    UniProtKB/Swiss-Prot
    Q6PAJ1
    Related
    ENSMUSP00000126377, ENSMUST00000164107
    Conserved Domains (5) summary
    pfam09036
    Location:272
    Blast Score: 355
    Bcr-Abl_Oligo; Bcr-Abl oncoprotein oligomerization domain
    cd08686
    Location:9121032
    Blast Score: 581
    C2_ABR; C2 domain in the Active BCR (Breakpoint cluster region) Related protein
    cd00160
    Location:498688
    Blast Score: 370
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd04387
    Location:10511251
    Blast Score: 986
    RhoGAP_Bcr; RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, ...
    cd01228
    Location:693866
    Blast Score: 641
    PH_BCR-related; Breakpoint Cluster Region-related pleckstrin homology (PH) domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000076.6 

    Range
    75060560..75184923
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513060.1XP_006513123.1  

    Conserved Domains (4) summary
    pfam09036
    Location:272
    Blast Score: 353
    Bcr-Abl_Oligo; Bcr-Abl oncoprotein oligomerization domain
    cd00160
    Location:498688
    Blast Score: 374
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01228
    Location:693866
    Blast Score: 639
    PH_BCR-related; Breakpoint Cluster Region-related pleckstrin homology (PH) domain
    cl14603
    Location:9121003
    Blast Score: 456
    C2; C2 domain
  2. XM_006513061.1XP_006513124.1  

    Conserved Domains (4) summary
    cd08686
    Location:452572
    Blast Score: 574
    C2_ABR; C2 domain in the Active BCR (Breakpoint cluster region) Related protein
    cd00160
    Location:38228
    Blast Score: 350
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd04387
    Location:591791
    Blast Score: 970
    RhoGAP_Bcr; RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, ...
    cd01228
    Location:233406
    Blast Score: 636
    PH_BCR-related; Breakpoint Cluster Region-related pleckstrin homology (PH) domain

Alternate Mm_Celera

Genomic

  1. AC_000032.1 

    Range
    76108779..76233250
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)