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    UHMK1 U2AF homology motif (UHM) kinase 1 [ Homo sapiens (human) ]

    Gene ID: 127933, updated on 25-Jul-2015
    Official Symbol
    UHMK1provided by HGNC
    Official Full Name
    U2AF homology motif (UHM) kinase 1provided by HGNC
    Primary source
    HGNC:HGNC:19683
    See related
    Ensembl:ENSG00000152332; HPRD:12318; MIM:608849; Vega:OTTHUMG00000031373
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KIS; KIST; P-CIP2
    Summary
    The gene encodes a serine/threonine protein kinase that promotes cell cycle progression through G1 by phosphorylation of the cyclin-dependent kinase inhibitor 1B (p27Kip1), which causes nuclear export and degradation. The encoded protein is also thought to function in the adult nervous system and the gene has been associated with schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
    Orthologs
    See UHMK1 in Epigenomics, MapViewer
    Location:
    1q23.3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 1 NC_000001.11 (162497174..162529629)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (162466964..162499419)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene SH2 domain containing 1B Neighboring gene uncharacterized LOC105373471 Neighboring gene SLAM family member 6 pseudogene 1 Neighboring gene uncharacterized LOC105371497 Neighboring gene uncharacterized LOC105371503 Neighboring gene uncharacterized LOC102724358 Neighboring gene ubiquinol-cytochrome c reductase binding protein pseudogene 2

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ23015, DKFZp434C1613

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IC
    Inferred by Curator
    more info
    PubMed 
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ribonucleoprotein complex binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    transferase activity IC
    Inferred by Curator
    more info
    PubMed 
    Process Evidence Code Pubs
    cell cycle arrest IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuron projection development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptidyl-serine phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of translational initiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of protein export from nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    axon ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    dendrite cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    neuronal ribonucleoprotein granule ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    serine/threonine-protein kinase Kist
    Names
    KIS protein kinase
    PAM COOH-terminal interactor protein 2
    kinase interacting with leukemia-associated gene (stathmin)
    NP_001171692.1
    NP_653225.2
    NP_787062.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001184763.1NP_001171692.1  serine/threonine-protein kinase Kist isoform 2

      See identical proteins and their annotated locations for NP_001171692.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK058195, AL359699
      Consensus CDS
      CCDS53423.1
      UniProtKB/TrEMBL
      A0A0A6YYC2
      UniProtKB/Swiss-Prot
      Q8TAS1
      Related
      ENSP00000441226, ENST00000545294
      Conserved Domains (2) summary
      cd12465
      Location:244331
      RRM_UHMK1; RNA recognition motif found in U2AF homology motif kinase 1 (UHMK1) and similar proteins
      cl21453
      Location:16234
      PKc_like; Protein Kinases, catalytic domain
    2. NM_144624.2NP_653225.2  serine/threonine-protein kinase Kist isoform 3

      See identical proteins and their annotated locations for NP_653225.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an exon in the coding region, which results in a frameshift and an early stop codon, compared to variant 1. The encoded protein (isoform 3) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AL359699, BC026046
      Consensus CDS
      CCDS53424.1
      UniProtKB/Swiss-Prot
      Q8TAS1
      Related
      ENSP00000446416, ENST00000538489
      Conserved Domains (3) summary
      pfam00069
      Location:23304
      Pkinase; Protein kinase domain
      cd14020
      Location:22308
      STKc_KIS; Catalytic domain of the Serine/Threonine Kinase, Kinase Interacting with Stathmin (also called U2AF homology motif (UHM) kinase 1)
      cl17169
      Location:318341
      RRM_SF; RNA recognition motif (RRM) superfamily
    3. NM_175866.4NP_787062.1  serine/threonine-protein kinase Kist isoform 1

      See identical proteins and their annotated locations for NP_787062.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AJ536197, AL359699
      Consensus CDS
      CCDS1239.1
      UniProtKB/Swiss-Prot
      Q8TAS1
      Related
      ENSP00000420270, OTTHUMP00000029529, ENST00000489294, OTTHUMT00000076788
      Conserved Domains (3) summary
      cd12465
      Location:318405
      RRM_UHMK1; RNA recognition motif found in U2AF homology motif kinase 1 (UHMK1) and similar proteins
      pfam00069
      Location:23304
      Pkinase; Protein kinase domain
      cd14020
      Location:22308
      STKc_KIS; Catalytic domain of the Serine/Threonine Kinase, Kinase Interacting with Stathmin (also called U2AF homology motif (UHM) kinase 1)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p2 Primary Assembly

      Range
      162497174..162529629
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_921745.1 RNA Sequence

    Alternate CHM1_1.1

    Genomic

    1. NC_018912.2 Alternate CHM1_1.1

      Range
      163889473..163921905
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)